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THSD7A thrombospondin type 1 domain containing 7A [ Homo sapiens (human) ]

Gene ID: 221981, updated on 2-Aug-2021

Summary

Official Symbol
THSD7Aprovided by HGNC
Official Full Name
thrombospondin type 1 domain containing 7Aprovided by HGNC
Primary source
HGNC:HGNC:22207
See related
Ensembl:ENSG00000005108 MIM:612249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]
Expression
Broad expression in kidney (RPKM 4.1), placenta (RPKM 2.1) and 17 other tissues See more
Orthologs
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Genomic context

See THSD7A in Genome Data Viewer
Location:
7p21.3
Exon count:
30
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (11370365..11832198, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (11409992..11871824, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986697 Neighboring gene uncharacterized LOC105375153 Neighboring gene nucleophosmin 1 pseudogene 11 Neighboring gene uncharacterized LOC105375151 Neighboring gene THRAP3 pseudogene 3 Neighboring gene transmembrane protein 106B Neighboring gene von Willebrand factor D and EGF domains

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0960

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton reorganization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thrombospondin type-1 domain-containing protein 7A
Names
thrombospondin, type I, domain containing 7A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027670.1 RefSeqGene

    Range
    5001..466833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015204.3NP_056019.1  thrombospondin type-1 domain-containing protein 7A precursor

    See identical proteins and their annotated locations for NP_056019.1

    Status: REVIEWED

    Source sequence(s)
    AA297188, AB023177, AC004160, AC004614, AK001884, AK092252, BC030083, BF111945
    Consensus CDS
    CCDS47543.1
    UniProtKB/Swiss-Prot
    Q9UPZ6
    Related
    ENSP00000406482.2, ENST00000423059.9
    Conserved Domains (2) summary
    smart00209
    Location:197247
    TSP1; Thrombospondin type 1 repeats
    cl15278
    Location:364412
    TSP_1; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    11370365..11832198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715662.1XP_006715725.1  thrombospondin type-1 domain-containing protein 7A isoform X4

    Conserved Domains (2) summary
    smart00209
    Location:197247
    TSP1; Thrombospondin type 1 repeats
    cl15278
    Location:364412
    TSP_1; Thrombospondin type 1 domain
  2. XM_006715660.1XP_006715723.1  thrombospondin type-1 domain-containing protein 7A isoform X3

    Conserved Domains (2) summary
    smart00209
    Location:197247
    TSP1; Thrombospondin type 1 repeats
    cl15278
    Location:364412
    TSP_1; Thrombospondin type 1 domain
  3. XM_006715659.1XP_006715722.1  thrombospondin type-1 domain-containing protein 7A isoform X1

    Conserved Domains (2) summary
    smart00209
    Location:197247
    TSP1; Thrombospondin type 1 repeats
    cl15278
    Location:364412
    TSP_1; Thrombospondin type 1 domain
  4. XM_011515194.1XP_011513496.1  thrombospondin type-1 domain-containing protein 7A isoform X2

    See identical proteins and their annotated locations for XP_011513496.1

    Conserved Domains (2) summary
    smart00209
    Location:128178
    TSP1; Thrombospondin type 1 repeats
    cl15278
    Location:295343
    TSP_1; Thrombospondin type 1 domain
  5. XM_011515193.3XP_011513495.1  thrombospondin type-1 domain-containing protein 7A isoform X2

    See identical proteins and their annotated locations for XP_011513495.1

    Conserved Domains (2) summary
    smart00209
    Location:128178
    TSP1; Thrombospondin type 1 repeats
    cl15278
    Location:295343
    TSP_1; Thrombospondin type 1 domain

RNA

  1. XR_001744589.1 RNA Sequence

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