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Ttll10 tubulin tyrosine ligase-like family, member 10 [ Mus musculus (house mouse) ]

Gene ID: 330010, updated on 5-Mar-2024

Summary

Official Symbol
Ttll10provided by MGI
Official Full Name
tubulin tyrosine ligase-like family, member 10provided by MGI
Primary source
MGI:MGI:1921855
See related
Ensembl:ENSMUSG00000029074 AllianceGenome:MGI:1921855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ttll5; 4833412E22Rik; 4930595O22Rik
Summary
Enables protein-glycine ligase activity, elongating. Involved in protein polyglycylation. Located in axoneme and microtubule cytoskeleton. Is expressed in white fat. Orthologous to human TTLL10 (tubulin tyrosine ligase like 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 132.3) and colon adult (RPKM 7.2) See more
Orthologs
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Genomic context

Location:
4 E2; 4 87.82 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156119292..156135274, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (156034835..156050817, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16008 Neighboring gene predicted gene, 25982 Neighboring gene tumor necrosis factor receptor superfamily, member 18 Neighboring gene predicted gene 13648 Neighboring gene microRNA 429 Neighboring gene microRNA 200a

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-glycine ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-glycine ligase activity, elongating IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-glycine ligase activity, elongating IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein polyglycylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein polyglycylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein polyglycylase TTLL10
Names
tubulin tyrosine ligase-like family, member 5
tubulin--tyrosine ligase-like protein 10
NP_001355570.1
NP_083540.1
XP_036020095.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368641.1NP_001355570.1  protein polyglycylase TTLL10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627204
    Consensus CDS
    CCDS89873.1
    UniProtKB/Swiss-Prot
    A4Q9F3, Q3V0K4
    UniProtKB/TrEMBL
    V9GXT8
    Related
    ENSMUSP00000139316.2, ENSMUST00000184348.8
    Conserved Domains (1) summary
    cl17255
    Location:272525
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
  2. NM_029264.2NP_083540.1  protein polyglycylase TTLL10 isoform 1

    See identical proteins and their annotated locations for NP_083540.1

    Status: VALIDATED

    Source sequence(s)
    AK133079
    Consensus CDS
    CCDS19058.1
    UniProtKB/Swiss-Prot
    A4Q9F3, Q3V0K4
    UniProtKB/TrEMBL
    B1ASM0
    Related
    ENSMUSP00000055671.9, ENSMUST00000051509.15
    Conserved Domains (1) summary
    cl17255
    Location:243496
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    156119292..156135274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164202.1XP_036020095.1  protein polyglycylase TTLL10 isoform X1

    Conserved Domains (1) summary
    cl17255
    Location:292436
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain