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TTLL10 tubulin tyrosine ligase like 10 [ Homo sapiens (human) ]

Gene ID: 254173, updated on 13-Feb-2019

Summary

Official Symbol
TTLL10provided by HGNC
Official Full Name
tubulin tyrosine ligase like 10provided by HGNC
Primary source
HGNC:HGNC:26693
See related
Ensembl:ENSG00000162571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTLL5
Expression
Biased expression in testis (RPKM 6.9), lung (RPKM 0.7) and 1 other tissue See more
Orthologs

Genomic context

See TTLL10 in Genome Data Viewer
Location:
1p36.33
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (1173709..1197936)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1109286..1133315)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 200a Neighboring gene microRNA 429 Neighboring gene TTLL10 antisense RNA 1 Neighboring gene TNF receptor superfamily member 18 Neighboring gene TNF receptor superfamily member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36119, FLJ42131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT protein-glycine ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
NOT protein polyglycylation IDA
Inferred from Direct Assay
more info
PubMed 
protein polyglycylation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
inactive polyglycylase TTLL10
Names
tubulin tyrosine ligase-like family, member 10
tubulin tyrosine ligase-like family, member 5
tubulin--tyrosine ligase-like protein 10
NP_001123517.1
NP_694986.2
XP_005244795.1
XP_011539479.1
XP_016856395.1
XP_016856396.1
XP_016856397.1
XP_016856398.1
XP_016856399.1
XP_016856400.1
XP_016856401.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130045.1NP_001123517.1  inactive polyglycylase TTLL10 isoform 1

    See identical proteins and their annotated locations for NP_001123517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK124125, BC126154
    Consensus CDS
    CCDS44036.1
    UniProtKB/Swiss-Prot
    Q6ZVT0
    Related
    ENSP00000368591.1, ENST00000379289.5
    Conserved Domains (1) summary
    cl17255
    Location:284548
    ATP-grasp_4; ATP-grasp domain
  2. NM_153254.2NP_694986.2  inactive polyglycylase TTLL10 isoform 2

    See identical proteins and their annotated locations for NP_694986.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 5' and 3' termini, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (2) with shorter N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK093438, BC126152, BX117374
    Consensus CDS
    CCDS8.1
    UniProtKB/Swiss-Prot
    Q6ZVT0
    Related
    ENSP00000368590.3, ENST00000379288.3
    Conserved Domains (1) summary
    cl17255
    Location:211373
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    1173709..1197936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541177.2XP_011539479.1  inactive polyglycylase TTLL10 isoform X7

    See identical proteins and their annotated locations for XP_011539479.1

    UniProtKB/Swiss-Prot
    Q6ZVT0
    Conserved Domains (1) summary
    cl17255
    Location:284548
    ATP-grasp_4; ATP-grasp domain
  2. XM_017000912.1XP_016856401.1  inactive polyglycylase TTLL10 isoform X7

    UniProtKB/Swiss-Prot
    Q6ZVT0
    Conserved Domains (1) summary
    cl17255
    Location:284548
    ATP-grasp_4; ATP-grasp domain
  3. XM_017000906.1XP_016856395.1  inactive polyglycylase TTLL10 isoform X1

  4. XM_017000909.1XP_016856398.1  inactive polyglycylase TTLL10 isoform X4

  5. XM_017000911.1XP_016856400.1  inactive polyglycylase TTLL10 isoform X6

  6. XM_017000908.1XP_016856397.1  inactive polyglycylase TTLL10 isoform X3

  7. XM_017000910.2XP_016856399.1  inactive polyglycylase TTLL10 isoform X5

  8. XM_017000907.1XP_016856396.1  inactive polyglycylase TTLL10 isoform X2

  9. XM_005244738.1XP_005244795.1  inactive polyglycylase TTLL10 isoform X8

    UniProtKB/Swiss-Prot
    Q6ZVT0
    Conserved Domains (1) summary
    cl17255
    Location:211475
    ATP-grasp_4; ATP-grasp domain

RNA

  1. XR_001737089.1 RNA Sequence

  2. XR_001737088.1 RNA Sequence

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