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DNAJB2 DnaJ heat shock protein family (Hsp40) member B2 [ Homo sapiens (human) ]

Gene ID: 3300, updated on 27-Nov-2024

Summary

Official Symbol
DNAJB2provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B2provided by HGNC
Primary source
HGNC:HGNC:5228
See related
Ensembl:ENSG00000135924 MIM:604139; AllianceGenome:HGNC:5228
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSJ1; CMT2T; DSMA5; HMNR5; HSJ-1; HSPF3
Summary
This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Expression
Ubiquitous expression in brain (RPKM 54.3), testis (RPKM 27.3) and 25 other tissues See more
Orthologs
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Genomic context

See DNAJB2 in Genome Data Viewer
Location:
2q35
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219279366..219286895)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219764122..219771651)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220144088..220151617)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:220109882-220110464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12351 Neighboring gene serine/threonine kinase 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17148 Neighboring gene tubulin alpha 4a Neighboring gene tubulin alpha 4b Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220142208-220142912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220150891-220151858 Neighboring gene Sharpr-MPRA regulatory region 13803 Neighboring gene protein tyrosine phosphatase receptor type N Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17149 Neighboring gene microRNA 153-1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:220199445-220200644 Neighboring gene regulated endocrine specific protein 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif is identified to have a physical interaction with DnaJ (Hsp40) homolog, subfamily B, member 2 (DNAJB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Vpr vpr HIV-1 Vpr downregulates DNAJ protein homolog HSJ1 in PHA-stimulated PBMC PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Hsp70 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables proteasome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein transporter activity TAS
Traceable Author Statement
more info
PubMed 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-modified protein reader activity IDA
Inferred from Direct Assay
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chaperone-mediated protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of inclusion body assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of inclusion body assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron cellular homeostasis TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of ATP-dependent activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to unfolded protein TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dnaJ homolog subfamily B member 2
Names
DnaJ (Hsp40) homolog, subfamily B, member 2
dnaJ protein homolog 1
heat shock 40 kDa protein 3
heat shock protein J1
heat shock protein, neuronal DNAJ-like 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029553.1 RefSeqGene

    Range
    5049..12578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039550.2NP_001034639.1  dnaJ homolog subfamily B member 2 isoform a

    See identical proteins and their annotated locations for NP_001034639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform a.
    Source sequence(s)
    AC114803, BC047056
    Consensus CDS
    CCDS46519.1
    UniProtKB/TrEMBL
    C9JXB9
    Related
    ENSP00000375936.4, ENST00000392086.8
    Conserved Domains (1) summary
    COG0484
    Location:3110
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  2. NM_006736.6NP_006727.2  dnaJ homolog subfamily B member 2 isoform b

    See identical proteins and their annotated locations for NP_006727.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1. This results in a longer isoform (b) with a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC114803, BC047056, BF795662, BT007088, BX478051, CA392563
    Consensus CDS
    CCDS2439.1
    UniProtKB/Swiss-Prot
    A8K9P6, P25686, Q53QD7, Q8IUK1, Q8IUK2, Q96F52
    UniProtKB/TrEMBL
    A8K0R1
    Related
    ENSP00000338019.5, ENST00000336576.10
    Conserved Domains (1) summary
    COG0484
    Location:3110
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    219279366..219286895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    219764122..219771651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)