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DNAJB2 DnaJ heat shock protein family (Hsp40) member B2 [ Homo sapiens (human) ]

Gene ID: 3300, updated on 9-Sep-2018

Summary

Official Symbol
DNAJB2provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B2provided by HGNC
Primary source
HGNC:HGNC:5228
See related
Ensembl:ENSG00000135924 MIM:604139; Vega:OTTHUMG00000133134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSJ1; CMT2T; DSMA5; HSJ-1; HSPF3
Summary
This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Expression
Ubiquitous expression in brain (RPKM 54.3), testis (RPKM 27.3) and 25 other tissues See more
Orthologs

Genomic context

See DNAJB2 in Genome Data Viewer
Location:
2q35
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (219279318..219286900)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220144040..220151622)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 16 Neighboring gene tubulin alpha 4a Neighboring gene tubulin alpha 4b Neighboring gene protein tyrosine phosphatase, receptor type N Neighboring gene microRNA 153-1 Neighboring gene regulated endocrine specific protein 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif is identified to have a physical interaction with DnaJ (Hsp40) homolog, subfamily B, member 2 (DNAJB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Vpr vpr HIV-1 Vpr downregulates DNAJ protein homolog HSJ1 in PHA-stimulated PBMC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone-mediated protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of inclusion body assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
neuron cellular homeostasis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to unfolded protein TAS
Traceable Author Statement
more info
PubMed 
ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
intrinsic component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with proteasome complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dnaJ homolog subfamily B member 2
Names
DnaJ (Hsp40) homolog, subfamily B, member 2
dnaJ protein homolog 1
heat shock 40 kDa protein 3
heat shock protein J1
heat shock protein, neuronal DNAJ-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029553.1 RefSeqGene

    Range
    5001..12583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039550.1NP_001034639.1  dnaJ homolog subfamily B member 2 isoform a

    See identical proteins and their annotated locations for NP_001034639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform a.
    Source sequence(s)
    AC114803, AL547521, BC047056, BM689272, BX420085
    Consensus CDS
    CCDS46519.1
    UniProtKB/Swiss-Prot
    P25686
    Related
    ENSP00000375936.4, OTTHUMP00000205873, ENST00000392086.8, OTTHUMT00000335644
    Conserved Domains (1) summary
    COG0484
    Location:3110
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  2. NM_006736.5NP_006727.2  dnaJ homolog subfamily B member 2 isoform b

    See identical proteins and their annotated locations for NP_006727.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1. This results in a longer isoform (b) with a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC114803, AL547521, BC047056, BF795662, BM689272, BT007088, BX420085, BX478051, CA392563
    Consensus CDS
    CCDS2439.1
    UniProtKB/Swiss-Prot
    P25686
    Related
    ENSP00000338019.5, OTTHUMP00000164174, ENST00000336576.9, OTTHUMT00000256823
    Conserved Domains (1) summary
    COG0484
    Location:3110
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    219279318..219286900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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