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Fnip2 folliculin interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 329679, updated on 2-Nov-2024

Summary

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Official Symbol
Fnip2provided by MGI
Official Full Name
folliculin interacting protein 2provided by MGI
Primary source
MGI:MGI:2683054
See related
Ensembl:ENSMUSG00000061175 AllianceGenome:MGI:2683054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1450; D630023B12Rik
Summary
Predicted to enable ATPase inhibitor activity and protein-folding chaperone binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage. Acts upstream of or within with a positive effect on negative regulation of cell population proliferation. Located in cytoplasm. Orthologous to human FNIP2 (folliculin interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 5.2), placenta adult (RPKM 4.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fnip2 in Genome Data Viewer
Location:
3 E3; 3 34.91 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (79363556..79475458, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79455971..79568151, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF) 2 Neighboring gene RIKEN cDNA 6430573P05 gene Neighboring gene STARR-seq mESC enhancer starr_07995 Neighboring gene predicted gene, 40072 Neighboring gene sperm microtubule inner protein 2 Neighboring gene STARR-seq mESC enhancer starr_07997 Neighboring gene STARR-seq mESC enhancer starr_07998 Neighboring gene STARR-seq mESC enhancer starr_07999 Neighboring gene STARR-seq mESC enhancer starr_08000 Neighboring gene STARR-seq mESC enhancer starr_08002 Neighboring gene RIKEN cDNA 4930589L23 gene Neighboring gene STARR-seq mESC enhancer starr_08006 Neighboring gene peptidylprolyl isomerase D (cyclophilin D) Neighboring gene electron transferring flavoprotein, dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3' untranslated region. Fernández LP, et al. Genome Biol, 2022 Oct 31. PMID 36316722, Free PMC Article
  2. Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA. Lim TH, et al. DNA Repair (Amst), 2012 Mar 1. PMID 22209521
  3. A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA. Komori K, et al. Oncogene, 2009 Feb 26. PMID 19137017
  4. Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1. Shillingford JM, et al. Am J Physiol Renal Physiol, 2023 Apr 1. PMID 36794754, Free PMC Article
  5. Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn. Hasumi H, et al. Proc Natl Acad Sci U S A, 2015 Mar 31. PMID 25775561, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn
    Title: Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn.
  2. The involvement of the AMPK-MAPO1-FLCN complex in the signaling pathway of apoptosis, is described.
    Title: Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables ATPase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_positive_effect negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP ISO
Inferred from Sequence Orthology
more info
  
part_of FNIP-folliculin RagC/D GAP ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
folliculin-interacting protein 2
Names
FNIP1-like protein
O6-methylguanine-induced apoptosis 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162999.3 → NP_001156471.1  folliculin-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001156471.1

    Status: VALIDATED

    Source sequence(s)
    AC113945, AC142502
    Consensus CDS
    CCDS50934.1
    UniProtKB/Swiss-Prot
    Q80TD3
    Related
    ENSMUSP00000075497.5, ENSMUST00000076136.7
    Conserved Domains (3) summary
    pfam14636
    Location:42 → 164
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:293 → 526
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:921 → 1104
    FNIP_C; Folliculin-interacting protein C-terminus

  2. NM_001405166.1 → NP_001392095.1  folliculin-interacting protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113945, AC142502

  3. NM_001405167.1 → NP_001392096.1  folliculin-interacting protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113945, AC142502

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    79363556..79475458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252651.1 → XP_030108511.1  folliculin-interacting protein 2 isoform X5

    Conserved Domains (3) summary
    pfam14636
    Location:56 → 111
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:274 → 507
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:902 → 1085
    FNIP_C; Folliculin-interacting protein C-terminus

  2. XM_036163138.1 → XP_036019031.1  folliculin-interacting protein 2 isoform X6

    UniProtKB/TrEMBL
    A7E1X7
    Conserved Domains (3) summary
    pfam14636
    Location:42 → 111
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:244 → 477
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:872 → 1055
    FNIP_C; Folliculin-interacting protein C-terminus

  3. XM_017319620.3 → XP_017175109.1  folliculin-interacting protein 2 isoform X2

    UniProtKB/TrEMBL
    D3YUC5
    Related
    ENSMUSP00000115275.2, ENSMUST00000133154.7
    Conserved Domains (3) summary
    pfam14636
    Location:42 → 160
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:323 → 556
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:951 → 1134
    FNIP_C; Folliculin-interacting protein C-terminus

  4. XM_017319622.3 → XP_017175111.1  folliculin-interacting protein 2 isoform X4

    Conserved Domains (3) summary
    pfam14636
    Location:69 → 138
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:301 → 534
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:929 → 1112
    FNIP_C; Folliculin-interacting protein C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TD3.2 GenPept UniProtKB/Swiss-Prot:Q80TD3

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