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Fnip2 folliculin interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 329679, updated on 7-May-2024

Summary

Official Symbol
Fnip2provided by MGI
Official Full Name
folliculin interacting protein 2provided by MGI
Primary source
MGI:MGI:2683054
See related
Ensembl:ENSMUSG00000061175 AllianceGenome:MGI:2683054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1450; D630023B12Rik
Summary
Predicted to enable ATPase inhibitor activity and chaperone binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage. Acts upstream of or within with a positive effect on negative regulation of cell population proliferation. Located in cytoplasm. Orthologous to human FNIP2 (folliculin interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 5.2), placenta adult (RPKM 4.8) and 28 other tissues See more
Orthologs
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Genomic context

See Fnip2 in Genome Data Viewer
Location:
3 E3; 3 34.91 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (79363556..79475458, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79455971..79568151, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF) 2 Neighboring gene RIKEN cDNA 6430573P05 gene Neighboring gene STARR-seq mESC enhancer starr_07995 Neighboring gene predicted gene, 40072 Neighboring gene sperm microtubule inner protein 2 Neighboring gene STARR-seq mESC enhancer starr_07997 Neighboring gene STARR-seq mESC enhancer starr_07998 Neighboring gene STARR-seq mESC enhancer starr_07999 Neighboring gene STARR-seq mESC enhancer starr_08000 Neighboring gene STARR-seq mESC enhancer starr_08002 Neighboring gene RIKEN cDNA 4930589L23 gene Neighboring gene STARR-seq mESC enhancer starr_08006 Neighboring gene peptidylprolyl isomerase D (cyclophilin D) Neighboring gene electron transferring flavoprotein, dehydrogenase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATPase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP ISO
Inferred from Sequence Orthology
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
folliculin-interacting protein 2
Names
FNIP1-like protein
O6-methylguanine-induced apoptosis 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162999.3NP_001156471.1  folliculin-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001156471.1

    Status: VALIDATED

    Source sequence(s)
    AC113945, AC142502
    Consensus CDS
    CCDS50934.1
    UniProtKB/Swiss-Prot
    Q80TD3
    Related
    ENSMUSP00000075497.5, ENSMUST00000076136.7
    Conserved Domains (3) summary
    pfam14636
    Location:42164
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:293526
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:9211104
    FNIP_C; Folliculin-interacting protein C-terminus
  2. NM_001405166.1NP_001392095.1  folliculin-interacting protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113945, AC142502
  3. NM_001405167.1NP_001392096.1  folliculin-interacting protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113945, AC142502

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    79363556..79475458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252651.1XP_030108511.1  folliculin-interacting protein 2 isoform X5

    Conserved Domains (3) summary
    pfam14636
    Location:56111
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:274507
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:9021085
    FNIP_C; Folliculin-interacting protein C-terminus
  2. XM_036163138.1XP_036019031.1  folliculin-interacting protein 2 isoform X6

    UniProtKB/TrEMBL
    A7E1X7
    Conserved Domains (3) summary
    pfam14636
    Location:42111
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:244477
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:8721055
    FNIP_C; Folliculin-interacting protein C-terminus
  3. XM_017319620.3XP_017175109.1  folliculin-interacting protein 2 isoform X2

    UniProtKB/TrEMBL
    D3YUC5
    Related
    ENSMUSP00000115275.2, ENSMUST00000133154.7
    Conserved Domains (3) summary
    pfam14636
    Location:42160
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:323556
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:9511134
    FNIP_C; Folliculin-interacting protein C-terminus
  4. XM_017319622.3XP_017175111.1  folliculin-interacting protein 2 isoform X4

    Conserved Domains (3) summary
    pfam14636
    Location:69138
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:301534
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:9291112
    FNIP_C; Folliculin-interacting protein C-terminus