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FNIP2 folliculin interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 57600, updated on 4-Jun-2020

Summary

Official Symbol
FNIP2provided by HGNC
Official Full Name
folliculin interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:29280
See related
Ensembl:ENSG00000052795 MIM:612768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FNIPL; MAPO1
Summary
This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in kidney (RPKM 11.0), fat (RPKM 8.4) and 25 other tissues See more
Orthologs

Genomic context

See FNIP2 in Genome Data Viewer
Location:
4q32.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (158769026..158908050)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (159690182..159829202)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene chromosome 4 open reading frame 46 Neighboring gene electron transfer flavoprotein dehydrogenase Neighboring gene peptidylprolyl isomerase D Neighboring gene RNA, U6 small nuclear 128, pseudogene Neighboring gene chromosome 4 open reading frame 45 Neighboring gene proteasome activator subunit 2 pseudogene 3 Neighboring gene fatty acid binding protein 5 pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1450

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
centriolar satellite IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
folliculin-interacting protein 2
Names
FNIP1-like protein
O6-methylguanine-induced apoptosis 1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323916.2NP_001310845.1  folliculin-interacting protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB040883, AC093700, AC107219, BC016638
    UniProtKB/Swiss-Prot
    Q9P278
    Conserved Domains (3) summary
    pfam14636
    Location:69187
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:320553
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:9501133
    FNIP_C; Folliculin-interacting protein C-terminus
  2. NM_001346043.2NP_001332972.1  folliculin-interacting protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AB040883, AC093700, BM806956, HY049314
    UniProtKB/Swiss-Prot
    Q9P278
  3. NM_001366843.1NP_001353772.1  folliculin-interacting protein 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC093700, AC107219, AC109823
    Conserved Domains (3) summary
    pfam14636
    Location:69187
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:350583
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:9801163
    FNIP_C; Folliculin-interacting protein C-terminus
  4. NM_020840.3NP_065891.1  folliculin-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_065891.1

    Status: REVIEWED

    Source sequence(s)
    AB040883, AC093700, HY049314
    Consensus CDS
    CCDS47155.1
    UniProtKB/Swiss-Prot
    Q9P278
    Related
    ENSP00000264433.6, ENST00000264433.11
    Conserved Domains (3) summary
    pfam14636
    Location:46164
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:297530
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:9271110
    FNIP_C; Folliculin-interacting protein C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    158769026..158908050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263158.2XP_005263215.1  folliculin-interacting protein 2 isoform X3

    Conserved Domains (3) summary
    pfam14636
    Location:46164
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:327560
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:9571140
    FNIP_C; Folliculin-interacting protein C-terminus
  2. XM_017008487.1XP_016863976.1  folliculin-interacting protein 2 isoform X2

  3. XM_024454161.1XP_024309929.1  folliculin-interacting protein 2 isoform X5

    Conserved Domains (3) summary
    pfam14636
    Location:69187
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:350583
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:9801036
    FNIP_C; Folliculin-interacting protein C-terminus
  4. XM_005263160.3XP_005263217.1  folliculin-interacting protein 2 isoform X4

    Conserved Domains (3) summary
    pfam14636
    Location:69187
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:350583
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:9801036
    FNIP_C; Folliculin-interacting protein C-terminus

RNA

  1. XR_001741297.1 RNA Sequence

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