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Atg2a autophagy related 2A [ Mus musculus (house mouse) ]

Gene ID: 329015, updated on 2-Nov-2024

Summary

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Official Symbol
Atg2aprovided by MGI
Official Full Name
autophagy related 2Aprovided by MGI
Primary source
MGI:MGI:1916291
See related
Ensembl:ENSMUSG00000024773 AllianceGenome:MGI:1916291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0404; A830054M12; 1810013C15Rik
Summary
Predicted to enable lipid transfer activity; phosphatidylinositol-3-phosphate binding activity; and protein-membrane adaptor activity. Predicted to be involved in autophagy of mitochondrion; macroautophagy; and positive regulation of autophagosome assembly. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and phagophore assembly site membrane. Predicted to be active in organelle membrane contact site; phagophore; and phagophore assembly site. Orthologous to human ATG2A (autophagy related 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 34.8), thymus adult (RPKM 26.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Atg2a in Genome Data Viewer
Location:
19 A; 19 4.37 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6291508..6312332)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6241478..6262304)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene membrane anchored junction protein Neighboring gene protein phosphatase 2, regulatory subunit B', beta Neighboring gene glycoprotein hormone alpha 2 Neighboring gene STARR-positive B cell enhancer ABC_E9990 Neighboring gene STARR-positive B cell enhancer ABC_E5681 Neighboring gene STARR-positive B cell enhancer ABC_E619 Neighboring gene microRNA 194-2 Neighboring gene microRNA 192

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans. Nicola AM, et al. Infect Immun, 2012 Sep. PMID 22710871, Free PMC Article
  2. The LMO2 oncogene regulates DNA replication in hematopoietic cells. Sincennes MC, et al. Proc Natl Acad Sci U S A, 2016 Feb 2. PMID 26764384, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC67447

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in pexophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
is_active_in organelle membrane contact site ISO
Inferred from Sequence Orthology
more info
  
is_active_in organelle membrane contact site ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in phagophore IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
autophagy-related protein 2 homolog A
Names
ATG2 autophagy related 2 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408280.1 → NP_001395209.1  autophagy-related protein 2 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127556
    Related
    ENSMUSP00000114998.2, ENSMUST00000145600.2

  2. NM_001408281.1 → NP_001395210.1  autophagy-related protein 2 homolog A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127556

  3. NM_194348.4 → NP_919329.2  autophagy-related protein 2 homolog A isoform 2

    See identical proteins and their annotated locations for NP_919329.2

    Status: VALIDATED

    Source sequence(s)
    AC127556
    Consensus CDS
    CCDS29500.1
    UniProtKB/Swiss-Prot
    Q3U9I1, Q6P4T0, Q6PHN0, Q6ZQC4, Q8R213
    UniProtKB/TrEMBL
    F6V3Y9
    Related
    ENSMUSP00000046412.7, ENSMUST00000045351.13
    Conserved Domains (2) summary
    pfam09333
    Location:1815 → 1908
    ATG_C; Autophagy-related protein C terminal domain
    pfam12624
    Location:14 → 111
    Chorein_N; N-terminal region of Chorein or VPS13

RNA

  1. NR_176623.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127556

  2. NR_176624.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127556

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6291508..6312332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531773.4 → XP_006531836.1  autophagy-related protein 2 homolog A isoform X2

    Conserved Domains (1) summary
    pfam09333
    Location:1082 → 1175
    ATG_C; Autophagy-related protein C terminal domain

  2. XM_006531774.5 → XP_006531837.1  autophagy-related protein 2 homolog A isoform X3

    Conserved Domains (1) summary
    pfam09333
    Location:976 → 1069
    ATG_C; Autophagy-related protein C terminal domain

  3. XM_006531775.5 → XP_006531838.1  autophagy-related protein 2 homolog A isoform X4

    Conserved Domains (1) summary
    pfam09333
    Location:931 → 1024
    ATG_C; Autophagy-related protein C terminal domain

RNA

  1. XR_004940153.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P4T0.2 GenPept UniProtKB/Swiss-Prot:Q6P4T0

Gene LinkOut

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