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ATG2A autophagy related 2A [ Homo sapiens (human) ]

Gene ID: 23130, updated on 9-Sep-2018

Summary

Official Symbol
ATG2Aprovided by HGNC
Official Full Name
autophagy related 2Aprovided by HGNC
Primary source
HGNC:HGNC:29028
See related
Ensembl:ENSG00000110046 MIM:616225; Vega:OTTHUMG00000066831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 17.3), spleen (RPKM 4.8) and 25 other tissues See more
Orthologs

Genomic context

See ATG2A in Genome Data Viewer
Location:
11q13.1
Exon count:
41
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (64894532..64917250, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64662004..64684722, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MIR194-2 host gene Neighboring gene microRNA 194-2 Neighboring gene microRNA 192 Neighboring gene microRNA 6750 Neighboring gene microRNA 6749 Neighboring gene protein phosphatase 2 regulatory subunit B'beta Neighboring gene glycoprotein hormone alpha 2 Neighboring gene membrane anchored junction protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - other, organism-specific biosystem (from KEGG)
    Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
  • Autophagy - other, conserved biosystem (from KEGG)
    Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0404, MGC117153

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lipid droplet IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
autophagy-related protein 2 homolog A
Names
ATG2 autophagy related 2 homolog A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015104.2NP_055919.2  autophagy-related protein 2 homolog A

    See identical proteins and their annotated locations for NP_055919.2

    Status: VALIDATED

    Source sequence(s)
    AI638563, AP001187, BC110650
    Consensus CDS
    CCDS31602.1
    UniProtKB/Swiss-Prot
    Q2TAZ0
    Related
    ENSP00000366475.3, OTTHUMP00000069743, ENST00000377264.7, OTTHUMT00000143224
    Conserved Domains (2) summary
    pfam09333
    Location:18391932
    ATG_C; Autophagy-related protein C terminal domain
    pfam12624
    Location:14108
    Chorein_N; N-terminal region of Chorein or VPS13

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    64894532..64917250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273850.3XP_005273907.1  autophagy-related protein 2 homolog A isoform X4

    Conserved Domains (2) summary
    pfam09333
    Location:18311924
    ATG_C; Autophagy-related protein C terminal domain
    pfam12624
    Location:14108
    Chorein_N; N-terminal region of Chorein or VPS13
  2. XM_005273849.3XP_005273906.1  autophagy-related protein 2 homolog A isoform X3

    Conserved Domains (2) summary
    pfam09333
    Location:18331926
    ATG_C; Autophagy-related protein C terminal domain
    pfam12624
    Location:14108
    Chorein_N; N-terminal region of Chorein or VPS13
  3. XM_011544863.2XP_011543165.1  autophagy-related protein 2 homolog A isoform X1

    UniProtKB/Swiss-Prot
    Q2TAZ0
    Conserved Domains (2) summary
    pfam09333
    Location:18411934
    ATG_C; Autophagy-related protein C terminal domain
    pfam12624
    Location:14108
    Chorein_N; N-terminal region of Chorein or VPS13
  4. XM_011544864.2XP_011543166.1  autophagy-related protein 2 homolog A isoform X2

    Conserved Domains (2) summary
    pfam09333
    Location:18361929
    ATG_C; Autophagy-related protein C terminal domain
    pfam12624
    Location:14108
    Chorein_N; N-terminal region of Chorein or VPS13
  5. XM_011544865.2XP_011543167.1  autophagy-related protein 2 homolog A isoform X5

    Related
    ENSP00000413716.1, OTTHUMP00000069745, ENST00000418259.5, OTTHUMT00000143227
    Conserved Domains (2) summary
    pfam09333
    Location:17761869
    ATG_C; Autophagy-related protein C terminal domain
    pfam12624
    Location:143
    Chorein_N; N-terminal region of Chorein or VPS13
  6. XM_011544866.2XP_011543168.1  autophagy-related protein 2 homolog A isoform X6

    Conserved Domains (1) summary
    pfam12624
    Location:14108
    Chorein_N; N-terminal region of Chorein or VPS13
  7. XM_011544867.3XP_011543169.1  autophagy-related protein 2 homolog A isoform X7

    Conserved Domains (1) summary
    pfam12624
    Location:14108
    Chorein_N; N-terminal region of Chorein or VPS13

RNA

  1. XR_001747796.2 RNA Sequence

  2. XR_949848.2 RNA Sequence

  3. XR_949847.2 RNA Sequence

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