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HSBP1 heat shock factor binding protein 1 [ Homo sapiens (human) ]

Gene ID: 3281, updated on 7-Jun-2020

Summary

Official Symbol
HSBP1provided by HGNC
Official Full Name
heat shock factor binding protein 1provided by HGNC
Primary source
HGNC:HGNC:5203
See related
Ensembl:ENSG00000230989 MIM:604553
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPC-A-13
Summary
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 51.9), thyroid (RPKM 45.3) and 25 other tissues See more
Orthologs

Genomic context

See HSBP1 in Genome Data Viewer
Location:
16q23.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (83807978..83819737)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (83841508..83846607)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene cadherin 13 Neighboring gene uncharacterized LOC105371366 Neighboring gene uncharacterized LOC102724163 Neighboring gene uncharacterized LOC105371372 Neighboring gene malonyl-CoA decarboxylase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686D1664, DKFZp686O24200

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular heat acclimation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
muscle contraction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
heat shock factor-binding protein 1
Names
nasopharyngeal carcinoma-associated antigen 13

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001537.4NP_001528.1  heat shock factor-binding protein 1

    See identical proteins and their annotated locations for NP_001528.1

    Status: REVIEWED

    Source sequence(s)
    AC009119, AK172732, BC007515, DB519225
    Consensus CDS
    CCDS45534.1
    UniProtKB/Swiss-Prot
    O75506
    Related
    ENSP00000392896.2, ENST00000433866.7
    Conserved Domains (1) summary
    pfam06825
    Location:1060
    HSBP1; Heat shock factor binding protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    83807978..83819737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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