U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dna2 DNA replication helicase/nuclease 2 [ Mus musculus (house mouse) ]

Gene ID: 327762, updated on 26-Sep-2022

Summary

Official Symbol
Dna2provided by MGI
Official Full Name
DNA replication helicase/nuclease 2provided by MGI
Primary source
MGI:MGI:2443732
See related
Ensembl:ENSMUSG00000036875 AllianceGenome:MGI:2443732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dna2l; E130315B21Rik
Summary
Enables 5'-flap endonuclease activity. Involved in mitotic telomere maintenance via semi-conservative replication and nucleic acid phosphodiester bond hydrolysis. Located in chromosome, telomeric region. Human ortholog(s) of this gene implicated in Seckel syndrome 8; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6; isolated growth hormone deficiency type IA; and mitochondrial myopathy. Orthologous to human DNA2 (DNA replication helicase/nuclease 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 14.4), liver E14.5 (RPKM 13.2) and 18 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dna2 in Genome Data Viewer
Location:
10; 10 B4
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62782762..62809967)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62946983..62974188)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 Neighboring gene predicted gene, 25862 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene RUN and FYVE domain-containing 2 Neighboring gene heterogeneous nuclear ribonucleoprotein H3 Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene predicted gene 16143

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0083

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables 5'-3' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables 5'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 5'-flap endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 5'-flap endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables site-specific endodeoxyribonuclease activity, specific for altered base ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA double-strand break processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication, Okazaki fragment processing ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication, removal of RNA primer ISO
Inferred from Sequence Orthology
more info
 
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic telomere maintenance via semi-conservative replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleic acid phosphodiester bond hydrolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in replication fork reversal IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of gamma DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA replication ATP-dependent helicase/nuclease DNA2
Names
DNA replication ATP-dependent helicase-like homolog
DNA replication helicase 2 homolog
DNA2-like helicase
NP_796346.2
XP_036011717.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177372.3NP_796346.2  DNA replication ATP-dependent helicase/nuclease DNA2

    See identical proteins and their annotated locations for NP_796346.2

    Status: VALIDATED

    Source sequence(s)
    AK028381, AK053856, BM202919, BY768981, CO433698
    Consensus CDS
    CCDS35923.1
    UniProtKB/Swiss-Prot
    Q6ZQJ5, Q8R3J3
    Related
    ENSMUSP00000115750.2, ENSMUST00000131422.8
    Conserved Domains (5) summary
    TIGR00376
    Location:4721034
    TIGR00376; DNA helicase, putative
    pfam08696
    Location:72283
    Dna2; DNA replication factor Dna2
    pfam13087
    Location:8061020
    AAA_12; AAA domain
    cl00641
    Location:256398
    Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
    cl21455
    Location:626830
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. NR_152862.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA407737, AK028381, AK053856, BY768981, CO433698

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62782762..62809967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155824.1XP_036011717.1  DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1

    Related
    ENSMUSP00000090119.6, ENSMUST00000092462.12
    Conserved Domains (3) summary
    TIGR00376
    Location:472934
    TIGR00376; DNA helicase, putative
    cd18041
    Location:626829
    DEXXQc_DNA2; DEXXQ-box helicase domain of DNA2
    cd22318
    Location:127366
    DNA2_N-like; Nuclease domain of the nuclease/helicase DNA2 and related nucleases

RNA

  1. XR_380405.5 RNA Sequence