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PRMT1 protein arginine methyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 3276, updated on 6-Sep-2021

Summary

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Official Symbol
PRMT1provided by HGNC
Official Full Name
protein arginine methyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:5187
See related
Ensembl:ENSG00000126457 MIM:602950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANM1; HCP1; IR1B4; HRMT1L2
Summary
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in ovary (RPKM 42.8), heart (RPKM 38.0) and 25 other tissues See more
Orthologs
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Genomic context

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See PRMT1 in Genome Data Viewer
Location:
19q13.33
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49676166..49688447)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50180528..50191704)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SR-related CTD associated factor 1 Neighboring gene interferon regulatory factor 3 Neighboring gene BCL2 like 12 Neighboring gene microRNA 5088 Neighboring gene adrenomedullin 5 (putative) Neighboring gene carnitine palmitoyltransferase 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Giuliani V, et al. Nat Commun, 2021 Jul 30. PMID 34330913, Free PMC Article
  2. PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Wang J, et al. Theranostics, 2021. PMID 33859753, Free PMC Article
  3. The methyltransferase PRMT1 regulates γ-globin translation. Wang Y, et al. J Biol Chem, 2021 Jan-Jun. PMID 33587951, Free PMC Article
  4. Roles of protein arginine methyltransferase 1 (PRMT1) in brain development and disease. Hashimoto M, et al. Biochim Biophys Acta Gen Subj, 2021 Jan. PMID 33127433
  5. PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin. Musiani D, et al. Cell Rep, 2020 Jan 28. PMID 31995759

See all (337) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA NNT-AS1 promote glioma cell proliferation and metastases through miR-494-3p/PRMT1 axis.
    Title: LncRNA NNT-AS1 promote glioma cell proliferation and metastases through miR-494-3p/PRMT1 axis.
  2. The methyltransferase PRMT1 regulates gamma-globin translation.
    Title: The methyltransferase PRMT1 regulates γ-globin translation.
  3. PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma.
    Title: PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma.
  4. PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.
    Title: PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.
  5. PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
    Title: PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
  6. Abnormalities of the PRMT1-ADMA-DDAH1 metabolism axis and probucol treatment in diabetic patients and diabetic rats.
    Title: Abnormalities of the PRMT1-ADMA-DDAH1 metabolism axis and probucol treatment in diabetic patients and diabetic rats.
  7. SCYL1 arginine methylation by PRMT1 is essential for neurite outgrowth via Golgi morphogenesis.
    Title: SCYL1 arginine methylation by PRMT1 is essential for neurite outgrowth via Golgi morphogenesis.
  8. TC-E 5003, a protein methyltransferase 1 inhibitor, activates the PKA-dependent thermogenic pathway in primary murine and human subcutaneous adipocytes.
    Title: TC-E 5003, a protein methyltransferase 1 inhibitor, activates the PKA-dependent thermogenic pathway in primary murine and human subcutaneous adipocytes.
  9. PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells.
    Title: PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells.
  10. UBAP2L arginine methylation by PRMT1 modulates stress granule assembly.
    Title: UBAP2L arginine methylation by PRMT1 modulates stress granule assembly.
Submit: New GeneRIF Correction See all GeneRIFs (161)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with protein arginine methyltransferase 1 (PRMT1; ANM1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
nucleocapsid gag HIV-1 NC is identified to have a physical interaction with protein arginine methyltransferase 1 (PRMT1; ANM1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA binding HDA PubMed 
enables S-adenosyl-L-methionine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity (H4-R3 specific) IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity (H4-R3 specific) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables methyl-CpG binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables mitogen-activated protein kinase p38 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein methyltransferase activity TAS
Traceable Author Statement
more info
  
enables protein-arginine N-methyltransferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein-arginine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-arginine N-methyltransferase activity TAS
Traceable Author Statement
more info
  
enables protein-arginine omega-N asymmetric methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-arginine omega-N asymmetric methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-arginine omega-N monomethyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cardiac muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in histone H4-R3 methylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in histone H4-R3 methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in histone methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of megakaryocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-arginine methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hemoglobin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of p38MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of megakaryocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of methylosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein arginine N-methyltransferase 1
Names
HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2
heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2
histone-arginine N-methyltransferase PRMT1
interferon receptor 1-bound protein 4
NP_001193971.1
NP_001527.3
NP_938074.2
XP_005258899.1
XP_016882223.1
XP_016882224.1
XP_016882225.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031846.1 RefSeqGene

    Range
    5001..16299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001207042.3 → NP_001193971.1  protein arginine N-methyltransferase 1 isoform 4

    See identical proteins and their annotated locations for NP_001193971.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AI193116, BX352789, DC421815
    Consensus CDS
    CCDS74425.1
    UniProtKB/TrEMBL
    A0A087X1W2
    Related
    ENSP00000484505.1, ENST00000610806.4
    Conserved Domains (1) summary
    cd02440
    Location:74 → 143
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_001536.6 → NP_001527.3  protein arginine N-methyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001527.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK304660, DC421815, Y10806
    Consensus CDS
    CCDS46145.1
    UniProtKB/Swiss-Prot
    Q99873
    UniProtKB/TrEMBL
    H7C2I1
    Related
    ENSP00000406162.2, ENST00000454376.7
    Conserved Domains (1) summary
    cd02440
    Location:92 → 192
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. NM_198318.5 → NP_938074.2  protein arginine N-methyltransferase 1 isoform 3

    See identical proteins and their annotated locations for NP_938074.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    DC421815, Y10807
    Consensus CDS
    CCDS42592.1
    UniProtKB/Swiss-Prot
    Q99873
    Related
    ENSP00000375724.4, ENST00000391851.8
    Conserved Domains (1) summary
    cd02440
    Location:74 → 174
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. NR_033397.5 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI193116, CN264743, CR407608

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49676166..49688447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026736.1 → XP_016882225.1  protein arginine N-methyltransferase 1 isoform X2

    Related
    ENSP00000433556.1, ENST00000532489.5
    Conserved Domains (1) summary
    cd02440
    Location:63 → 163
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_017026735.1 → XP_016882224.1  protein arginine N-methyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q99873
    Conserved Domains (1) summary
    cd02440
    Location:68 → 168
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_017026734.1 → XP_016882223.1  protein arginine N-methyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q99873
    Conserved Domains (1) summary
    cd02440
    Location:68 → 168
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. XM_005258842.1 → XP_005258899.1  protein arginine N-methyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_005258899.1

    Conserved Domains (1) summary
    cd02440
    Location:63 → 163
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198319.2: Suppressed sequence

    Description
    NM_198319.2: This RefSeq was permanently suppressed because it contains a uORF at nt 43..240 that is predicted to inhibit translation of the annotated CDS.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99873.3 GenPept UniProtKB/Swiss-Prot:Q99873

Gene LinkOut

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