PRMT1 protein arginine methyltransferase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRMT1provided by HGNC
Official Full Name: protein arginine methyltransferase 1provided by HGNC
Primary source: HGNC:HGNC:5187
See related: Ensembl:ENSG00000126457 MIM:602950
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ANM1; HCP1; IR1B4; HRMT1L2
Summary: This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
Expression: Ubiquitous expression in ovary (RPKM 42.8), heart (RPKM 38.0) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 19q13.33

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109.20200815	current	GRCh38.p13 (GCF_000001405.39)	19	NC_000019.10 (49676166..49688447)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (50180409..50191707)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study uncovers a novel regulatory mechanism for PRMT1 by Ca(2+) and identifies the PRMT1/p38a axis as an intracellular mediator of Ca(2+) signaling during erythroid differentiation.
Title: Calcium-dependent methylation by PRMT1 promotes erythroid differentiation through the p38α MAPK pathway.
RALY regulates PRMT1 expression and interacts with the amyotrophic lateral sclerosis-linked protein FUS.
Title: The hnRNP RALY regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization.
Protein arginine methyltranferase-1 induces ER stress and epithelial-mesenchymal transition in renal tubular epithelial cells and contributes to diabetic nephropathy.
Title: Protein arginine methyltranferase-1 induces ER stress and epithelial-mesenchymal transition in renal tubular epithelial cells and contributes to diabetic nephropathy.
PRMT1 regulates the tumor-initiating properties of esophageal squamous cell carcinoma through histone H4 arginine methylation coupled with transcriptional activation.
Title: PRMT1 regulates the tumour-initiating properties of esophageal squamous cell carcinoma through histone H4 arginine methylation coupled with transcriptional activation.
expression of PRMT1 may be characteristic for low grade and low stage clear cell renal cell carcinomas
Title: PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance.
The role of the arginine methyltransferase PRMT1 in breast cancer pathogenesis.Elevated PRMT1 expression correlates with malignancy of breast cancer. CEBPA is methylated by PRMT1 in breast cancer.
Title: Methylation of C/EBPα by PRMT1 Inhibits Its Tumor-Suppressive Function in Breast Cancer.
PRMT1 down-regulation impairs global miRNA expression.
Title: PRMT1-mediated methylation of the microprocessor-associated proteins regulates microRNA biogenesis.
Data indicate protein arginine methyltransferase 1 (PRMT1) as a positive regulator of Yes-associated protein (YAP) activity in chondrosarcoma.
Title: PRMT1 potentiates chondrosarcoma development through activation of YAP activity.
The study revealed that PRMT1 methylates Fms-like receptor tyrosine kinase 3 (FLT3) at arginine (R) residues 972 and 973 (R972/973), and its oncogenic function in MLL - rearranged acute lymphoblastic leukemia cells is FLT3 methylation dependent.
Title: Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia.
PRMT1 promotes MyoD-mediated myogenin expression, for which the enzymatic activity of PRMT1 is needed. The arginine methylation of MyoD by PRMT1 enhances its DNA binding activity and transactivation.
Title: PRMT1 activates myogenin transcription via MyoD arginine methylation at R121.

Submit: New GeneRIF Correction See all GeneRIFs (143)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	HIV-1 Gag is identified to have a physical interaction with protein arginine methyltransferase 1 (PRMT1; ANM1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
nucleocapsid	gag	HIV-1 NC is identified to have a physical interaction with protein arginine methyltransferase 1 (PRMT1; ANM1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

RH91411 (e-PCR)
- UniSTS:84537

RH68301 (e-PCR)
- UniSTS:26699

Hrmt1l2 (e-PCR), detects polymorphism
- UniSTS:275867

STS-N90422 (e-PCR)
- UniSTS:26294

RH65905 (e-PCR)
- UniSTS:2775

NoName (e-PCR)
- UniSTS:486645

Homology

Homologs of the PRMT1 gene: The PRMT1 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 243 organisms have orthologs with human gene PRMT1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
N-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
RNA binding	HDA more info	PubMed
S-adenosyl-L-methionine binding	IDA Inferred from Direct Assay more info	PubMed
enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
histone methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
histone methyltransferase activity (H4-R3 specific)	IDA Inferred from Direct Assay more info	PubMed
histone methyltransferase activity (H4-R3 specific)	IMP Inferred from Mutant Phenotype more info	PubMed
identical protein binding	IDA Inferred from Direct Assay more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
methyl-CpG binding	IDA Inferred from Direct Assay more info	PubMed
methyltransferase activity	TAS Traceable Author Statement more info	PubMed
mitogen-activated protein kinase p38 binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
protein methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein-arginine N-methyltransferase activity	EXP Inferred from Experiment more info	PubMed
protein-arginine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
protein-arginine N-methyltransferase activity	TAS Traceable Author Statement more info
protein-arginine omega-N asymmetric methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
protein-arginine omega-N asymmetric methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein-arginine omega-N monomethyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	TAS Traceable Author Statement more info
cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
histone H4-R3 methylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
histone H4-R3 methylation	IDA Inferred from Direct Assay more info	PubMed
histone methylation	IDA Inferred from Direct Assay more info	PubMed
in utero embryonic development	IEA Inferred from Electronic Annotation more info
negative regulation of megakaryocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
peptidyl-arginine methylation	IDA Inferred from Direct Assay more info	PubMed
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	IEA Inferred from Electronic Annotation more info
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of hemoglobin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
protein methylation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of megakaryocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
regulation of megakaryocyte differentiation	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	IEA Inferred from Electronic Annotation more info
methylosome	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein arginine N-methyltransferase 1

Names: HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2; histone-arginine N-methyltransferase PRMT1; interferon receptor 1-bound protein 4

NP_001193971.1

EC 2.1.1.319

NP_001527.3

EC 2.1.1.319

NP_938074.2

EC 2.1.1.319

XP_005258899.1

EC 2.1.1.319

XP_016882223.1

EC 2.1.1.319

XP_016882224.1

EC 2.1.1.319

XP_016882225.1

EC 2.1.1.319

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_031846.1 RefSeqGene

Range

5001..16299

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001207042.3 → NP_001193971.1 protein arginine N-methyltransferase 1 isoform 4

See identical proteins and their annotated locations for NP_001193971.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks three exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AI193116, BX352789, DC421815

Consensus CDS

CCDS74425.1

UniProtKB/TrEMBL

A0A087X1W2

Related

ENSP00000484505.1, ENST00000610806.4

Conserved Domains (1) summary

cd02440
Location:74 → 143

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001536.6 → NP_001527.3 protein arginine N-methyltransferase 1 isoform 1

See identical proteins and their annotated locations for NP_001527.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK304660, DC421815, Y10806

Consensus CDS

CCDS46145.1

UniProtKB/Swiss-Prot

Q99873

UniProtKB/TrEMBL

H7C2I1

Related

ENSP00000406162.2, ENST00000454376.6

Conserved Domains (1) summary

cd02440
Location:92 → 192

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_198318.5 → NP_938074.2 protein arginine N-methyltransferase 1 isoform 3

See identical proteins and their annotated locations for NP_938074.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

DC421815, Y10807

Consensus CDS

CCDS42592.1

UniProtKB/Swiss-Prot

Q99873

Related

ENSP00000375724.4, ENST00000391851.8

Conserved Domains (1) summary

cd02440
Location:74 → 174

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

NR_033397.5 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AI193116, CN264743, CR407608

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p13 Primary Assembly

Range

49676166..49688447

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017026736.1 → XP_016882225.1 protein arginine N-methyltransferase 1 isoform X2

Related

ENSP00000433556.1, ENST00000532489.5

Conserved Domains (1) summary

cd02440
Location:63 → 163

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_017026735.1 → XP_016882224.1 protein arginine N-methyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q99873

Conserved Domains (1) summary

cd02440
Location:68 → 168

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_017026734.1 → XP_016882223.1 protein arginine N-methyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q99873

Conserved Domains (1) summary

cd02440
Location:68 → 168

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_005258842.1 → XP_005258899.1 protein arginine N-methyltransferase 1 isoform X2

See identical proteins and their annotated locations for XP_005258899.1

Conserved Domains (1) summary

cd02440
Location:63 → 163

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_198319.2: Suppressed sequence

Description

NM_198319.2: This RefSeq was permanently suppressed because it contains a uORF at nt 43..240 that is predicted to inhibit translation of the annotated CDS.