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Tpm4 tropomyosin 4 [ Mus musculus (house mouse) ]

Gene ID: 326618, updated on 5-Mar-2024

Summary

Official Symbol
Tpm4provided by MGI
Official Full Name
tropomyosin 4provided by MGI
Primary source
MGI:MGI:2449202
See related
Ensembl:ENSMUSG00000031799 AllianceGenome:MGI:2449202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tpm4.2; Tpm4.2cy; 2610528G24Rik
Summary
Enables actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Located in cortical cytoskeleton and podosome. Orthologous to human TPM4 (tropomyosin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 203.2), CNS E11.5 (RPKM 138.7) and 24 other tissues See more
Orthologs
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Genomic context

See Tpm4 in Genome Data Viewer
Location:
8 B3.3; 8 34.81 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72889132..72906986)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72135288..72153142)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily AB member 2 Neighboring gene predicted gene, 39196 Neighboring gene STARR-positive B cell enhancer ABC_E1371 Neighboring gene STARR-positive B cell enhancer ABC_E8245 Neighboring gene STARR-positive B cell enhancer ABC_E243 Neighboring gene STARR-positive B cell enhancer ABC_E11387 Neighboring gene RAB8A, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E8246 Neighboring gene hematopoietic SH2 domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cortical cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in podosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001491.2NP_001001491.1  tropomyosin alpha-4 chain

    See identical proteins and their annotated locations for NP_001001491.1

    Status: VALIDATED

    Source sequence(s)
    AC158898, BC070421, BY230591
    Consensus CDS
    CCDS22408.1
    UniProtKB/Swiss-Prot
    Q6IRU2
    Related
    ENSMUSP00000003575.10, ENSMUST00000003575.11
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin; Tropomyosin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    72889132..72906986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)