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TPM4 tropomyosin 4 [ Homo sapiens (human) ]

Gene ID: 7171, updated on 12-Sep-2021

Summary

Official Symbol
TPM4provided by HGNC
Official Full Name
tropomyosin 4provided by HGNC
Primary source
HGNC:HGNC:12013
See related
Ensembl:ENSG00000167460 MIM:600317
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL-S-108
Summary
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Expression
Ubiquitous expression in gall bladder (RPKM 102.4), urinary bladder (RPKM 100.5) and 25 other tissues See more
Orthologs
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Genomic context

See TPM4 in Genome Data Viewer
Location:
19p13.12-p13.11
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (16067507..16103005)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16178348..16213812)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily AB member 1 pseudogene Neighboring gene long intergenic non-protein coding RNA 1855 Neighboring gene RAB8A, member RAS oncogene family Neighboring gene hematopoietic SH2 domain containing Neighboring gene calcium and integrin binding family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
GeneReviews: Not available
New gene functions in megakaryopoiesis and platelet formation.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables structural constituent of muscle TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in osteoblast differentiation HDA PubMed 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cortical cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 
part_of muscle thin filament tropomyosin TAS
Traceable Author Statement
more info
PubMed 
located_in podosome IEA
Inferred from Electronic Annotation
more info
 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tropomyosin alpha-4 chain
Names
TM30p1
epididymis secretory protein Li 108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015841.1 RefSeqGene

    Range
    5032..40496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1339

mRNA and Protein(s)

  1. NM_001145160.2NP_001138632.1  tropomyosin alpha-4 chain isoform Tpm4.1cy

    See identical proteins and their annotated locations for NP_001138632.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm4.1, also known as variant 1) encodes the longest isoform (Tpm4.1cy, also known as isoform 1).
    Source sequence(s)
    AC008894, AK023385
    Consensus CDS
    CCDS46007.1
    UniProtKB/Swiss-Prot
    P67936
    Related
    ENSP00000494125.1, ENST00000646974.2
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  2. NM_001367836.1NP_001354765.1  tropomyosin alpha-4 chain isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC008894
  3. NM_001367837.2NP_001354766.1  tropomyosin alpha-4 chain isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC008894
    Related
    ENSP00000494867.1, ENST00000645471.1
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin
  4. NM_001367838.1NP_001354767.1  tropomyosin alpha-4 chain isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC008894
    Related
    ENSP00000467087.3, ENST00000586833.7
    Conserved Domains (1) summary
    pfam00261
    Location:42243
    Tropomyosin
  5. NM_003290.3NP_003281.1  tropomyosin alpha-4 chain isoform Tpm4.2cy

    See identical proteins and their annotated locations for NP_003281.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm4.2, also known as variant 2) differs in the 5' UTR and coding sequence compared to variant Tpm4.1. The resulting isoform (Tpm4.2cy, also known as isoform 2) has a shorter and distinct N-terminus compared to isoform Tpm4.1cy.
    Source sequence(s)
    AC008894, BC037576
    Consensus CDS
    CCDS12338.1
    UniProtKB/Swiss-Prot
    P67936
    UniProtKB/TrEMBL
    V9HW56
    Related
    ENSP00000495347.1, ENST00000643579.2
    Conserved Domains (1) summary
    pfam00261
    Location:12246
    Tropomyosin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    16067507..16103005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722865.2XP_006722928.1  tropomyosin alpha-4 chain isoform X1

    See identical proteins and their annotated locations for XP_006722928.1

    Related
    ENSP00000496648.2, ENST00000647464.2
    Conserved Domains (1) summary
    pfam00261
    Location:48282
    Tropomyosin
  2. XM_024451681.1XP_024307449.1  tropomyosin alpha-4 chain isoform X5

    Related
    ENST00000664983.1
    Conserved Domains (1) summary
    pfam00261
    Location:1156
    Tropomyosin
  3. XM_011528232.1XP_011526534.1  tropomyosin alpha-4 chain isoform X5

    See identical proteins and their annotated locations for XP_011526534.1

    Related
    ENSP00000345230.6, ENST00000344824.11
    Conserved Domains (1) summary
    pfam00261
    Location:1156
    Tropomyosin
  4. XM_017027189.1XP_016882678.1  tropomyosin alpha-4 chain isoform X4

    Related
    ENST00000658224.1
    Conserved Domains (1) summary
    pfam00261
    Location:42243
    Tropomyosin
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