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Lmbrd2 LMBR1 domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 320506, updated on 9-May-2024

Summary

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Official Symbol
Lmbrd2provided by MGI
Official Full Name
LMBR1 domain containing 2provided by MGI
Primary source
MGI:MGI:2444173
See related
Ensembl:ENSMUSG00000039704 AllianceGenome:MGI:2444173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9930036E21Rik
Summary
Predicted to be involved in adrenergic receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in Meckel's cartilage; cranial ganglion; hindlimb long bone; and tarsus. Orthologous to human LMBRD2 (LMBR1 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 5.7), genital fat pad adult (RPKM 4.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lmbrd2 in Genome Data Viewer
Location:
15 A1; 15 3.86 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (9140622..9202564)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (9140528..9202483)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RAN binding protein 3-like Neighboring gene predicted gene, 53883 Neighboring gene STARR-positive B cell enhancer ABC_E1904 Neighboring gene STARR-seq mESC enhancer starr_37924 Neighboring gene NAD kinase 2, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E3131 Neighboring gene S-phase kinase-associated protein 2 Neighboring gene STARR-seq mESC enhancer starr_37931 Neighboring gene STARR-seq mESC enhancer starr_37932 Neighboring gene UDP glycosyltransferases 3 family pseudogene Neighboring gene UDP glycosyltransferases 3 family, polypeptide A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptor-associated protein LMBRD2
Names
LMBR1 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418870.1 → NP_001405799.1  G-protein coupled receptor-associated protein LMBRD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC139209
    UniProtKB/Swiss-Prot
    Q3U5C1, Q501M6, Q8BQ06, Q8C561

  2. NM_001418874.1 → NP_001405803.1  G-protein coupled receptor-associated protein LMBRD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC139209
    Related
    ENSMUSP00000087858.6, ENSMUST00000090380.6

  3. NM_001418875.1 → NP_001405804.1  G-protein coupled receptor-associated protein LMBRD2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139209

  4. NM_177178.4 → NP_796152.2  G-protein coupled receptor-associated protein LMBRD2 isoform 1

    See identical proteins and their annotated locations for NP_796152.2

    Status: VALIDATED

    Source sequence(s)
    AC139209
    Consensus CDS
    CCDS37039.1
    UniProtKB/Swiss-Prot
    Q3U5C1, Q501M6, Q8BQ06, Q8C561
    Related
    ENSMUSP00000154020.2, ENSMUST00000227556.3
    Conserved Domains (1) summary
    pfam04791
    Location:1 → 549
    LMBR1; LMBR1-like membrane protein

RNA

  1. NR_184843.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139209

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    9140622..9202564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520092.5 → XP_006520155.1  G-protein coupled receptor-associated protein LMBRD2 isoform X2

    Conserved Domains (1) summary
    pfam04791
    Location:1 → 421
    LMBR1; LMBR1-like membrane protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C561.1 GenPept UniProtKB/Swiss-Prot:Q8C561

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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