Tacc1 transforming, acidic coiled-coil containing protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tacc1provided by MGI
Official Full Name: transforming, acidic coiled-coil containing protein 1provided by MGI
Primary source: MGI:MGI:2443510
See related: Ensembl:ENSMUSG00000065954 AllianceGenome:MGI:2443510
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4833447E04Rik; B230378H13Rik
Summary: Enables nuclear receptor binding activity; peroxisome proliferator activated receptor binding activity; and protein domain specific binding activity. Acts upstream of or within microtubule cytoskeleton organization; nervous system development; and regulation of microtubule-based process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and respiratory system. Orthologous to human TACC1 (transforming acidic coiled-coil containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 20.7), bladder adult (RPKM 18.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8; 8 A2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (25644568..25746440, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (25154552..25256424, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we show that T cells deficient for acetyl-CoA carboxylase 1 (TACC1) are dramatically less pathogenic than wild-type (WT) T cells in a lethal C57BL/6 into BALB/c model of acute GVHD and permitted sustained survival of recipient mice.
Title: Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease.
Splice variants can be localized to different subcellular compartments in a cell-and tissue-specific manner.
Title: Temporal and spatial expression of TACC1 in the mouse and human.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA960202 (e-PCR)
- UniSTS:179721

RH137203 (e-PCR)
- UniSTS:219291

Homology

Homologs of the Tacc1 gene: The Tacc1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 470 organisms have orthologs with human gene Tacc1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear retinoic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoid X receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear retinoid X receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear thyroid hormone receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables peroxisome proliferator activated receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebral cortex development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interkinetic nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of microtubule-based process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transforming acidic coiled-coil-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001402841.1 → NP_001389770.1 transforming acidic coiled-coil-containing protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC114589
NM_001402842.1 → NP_001389771.1 transforming acidic coiled-coil-containing protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC114589
NM_001402843.1 → NP_001389772.1 transforming acidic coiled-coil-containing protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC114589
NM_177089.6 → NP_796063.3 transforming acidic coiled-coil-containing protein 1 long isoform

See identical proteins and their annotated locations for NP_796063.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the long isoform.

Source sequence(s)

AC114589

Consensus CDS

CCDS40303.1

UniProtKB/Swiss-Prot

Q6Y685

UniProtKB/TrEMBL

F8VQ95

Related

ENSMUSP00000081043.5, ENSMUST00000084030.6

Conserved Domains (3) summary

pfam05010
Location:570 → 769

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam09403
Location:675 → 768

FadA; Adhesion protein FadA

cl21478
Location:577 → 662

ATP-synt_B; ATP synthase B/B' CF(0)
NM_199323.4 → NP_955355.1 transforming acidic coiled-coil-containing protein 1 short isoform

See identical proteins and their annotated locations for NP_955355.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This encodes the short isoform, compared to the long isoform.

Source sequence(s)

AC114589

Consensus CDS

CCDS40302.1

UniProtKB/Swiss-Prot

Q6Y685

Related

ENSMUSP00000081560.5, ENSMUST00000084512.11

Conserved Domains (1) summary

pfam05010
Location:162 → 361

TACC; Transforming acidic coiled-coil-containing protein (TACC)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

25644568..25746440 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312859.2 → XP_017168348.1 transforming acidic coiled-coil-containing protein 1 isoform X5

Conserved Domains (2) summary

pfam05010
Location:401 → 600

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam15740
Location:48 → 211

PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
XM_006509146.5 → XP_006509209.1 transforming acidic coiled-coil-containing protein 1 isoform X7

Conserved Domains (1) summary

pfam05010
Location:121 → 320

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_030243614.1 → XP_030099474.1 transforming acidic coiled-coil-containing protein 1 isoform X4

Conserved Domains (2) summary

pfam05010
Location:552 → 751

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam15740
Location:199 → 362

PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
XM_030243613.2 → XP_030099473.1 transforming acidic coiled-coil-containing protein 1 isoform X2

Conserved Domains (2) summary

pfam05010
Location:540 → 739

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam15740
Location:199 → 362

PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
XM_036154099.1 → XP_036009992.1 transforming acidic coiled-coil-containing protein 1 isoform X3

Conserved Domains (1) summary

pfam05010
Location:479 → 678

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_030243615.2 → XP_030099475.1 transforming acidic coiled-coil-containing protein 1 isoform X6

Conserved Domains (1) summary

pfam05010
Location:132 → 331

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_006509143.4 → XP_006509206.1 transforming acidic coiled-coil-containing protein 1 isoform X1

Conserved Domains (2) summary

pfam05010
Location:582 → 781

TACC; Transforming acidic coiled-coil-containing protein (TACC)

pfam15740
Location:229 → 392

PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus