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TACC1 transforming acidic coiled-coil containing protein 1 [ Homo sapiens (human) ]

Gene ID: 6867, updated on 1-Aug-2020

Summary

Official Symbol
TACC1provided by HGNC
Official Full Name
transforming acidic coiled-coil containing protein 1provided by HGNC
Primary source
HGNC:HGNC:11522
See related
Ensembl:ENSG00000147526 MIM:605301
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ga55
Summary
This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Expression
Ubiquitous expression in fat (RPKM 59.1), endometrium (RPKM 38.3) and 24 other tissues See more
Orthologs

Genomic context

See TACC1 in Genome Data Viewer
Location:
8p11.22
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (38728205..38853028)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38585704..38710546)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379384 Neighboring gene ring finger protein 5 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 13542 Neighboring gene pleckstrin homology domain containing A2 Neighboring gene HtrA serine peptidase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42304, KIAA1103, DKFZp686K18126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
estrogen receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
glucocorticoid receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome proliferator activated receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoic acid receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
retinoid X receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nuclear receptor transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
midbody IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transforming acidic coiled-coil-containing protein 1
Names
gastric cancer antigen Ga55
taxin-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122824.2NP_001116296.1  transforming acidic coiled-coil-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001116296.1

    Status: REVIEWED

    Source sequence(s)
    AY139007, AY177411, DB084271
    Consensus CDS
    CCDS47845.1
    UniProtKB/Swiss-Prot
    O75410
    Related
    ENSP00000276520.8, ENST00000276520.12
    Conserved Domains (1) summary
    pfam05010
    Location:189388
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  2. NM_001146216.3NP_001139688.1  transforming acidic coiled-coil-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 16-18, encodes isoform 3.
    Source sequence(s)
    AB029026, AC067817, AY072876, BX647696
    Consensus CDS
    CCDS55224.1
    UniProtKB/Swiss-Prot
    O75410
    UniProtKB/TrEMBL
    Q5HYH0
    Related
    ENSP00000428450.1, ENST00000520615.5
    Conserved Domains (1) summary
    pfam05010
    Location:404603
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  3. NM_001330521.2NP_001317450.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 22-25, encodes isoform 4.
    Source sequence(s)
    AC067817, AI129797, BQ001033, DA152500, DA553264
    Consensus CDS
    CCDS83284.1
    UniProtKB/TrEMBL
    E7EVI4, Q5HYH0
    Conserved Domains (1) summary
    pfam05010
    Location:375574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  4. NM_001352778.2NP_001339707.1  transforming acidic coiled-coil-containing protein 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:615814
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  5. NM_001352779.2NP_001339708.1  transforming acidic coiled-coil-containing protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:611810
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  6. NM_001352780.2NP_001339709.1  transforming acidic coiled-coil-containing protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:586785
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  7. NM_001352781.2NP_001339710.1  transforming acidic coiled-coil-containing protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:582781
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  8. NM_001352782.2NP_001339711.1  transforming acidic coiled-coil-containing protein 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:571770
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  9. NM_001352783.2NP_001339712.1  transforming acidic coiled-coil-containing protein 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:570769
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  10. NM_001352784.2NP_001339713.1  transforming acidic coiled-coil-containing protein 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:542741
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  11. NM_001352785.2NP_001339714.1  transforming acidic coiled-coil-containing protein 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:534733
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  12. NM_001352786.2NP_001339715.1  transforming acidic coiled-coil-containing protein 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS87601.1
    Related
    ENSP00000428706.1, ENST00000518415.5
    Conserved Domains (1) summary
    pfam05010
    Location:525724
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  13. NM_001352787.2NP_001339716.1  transforming acidic coiled-coil-containing protein 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:563762
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  14. NM_001352788.2NP_001339717.1  transforming acidic coiled-coil-containing protein 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:416615
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  15. NM_001352789.2NP_001339718.1  transforming acidic coiled-coil-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 3, 17, and 18, encodes isoform 3.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS55224.1
    Conserved Domains (1) summary
    pfam05010
    Location:404603
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  16. NM_001352790.2NP_001339719.1  transforming acidic coiled-coil-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 3, 16, and 18, encodes isoform 3.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS55224.1
    Conserved Domains (1) summary
    pfam05010
    Location:404603
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  17. NM_001352791.1NP_001339720.1  transforming acidic coiled-coil-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 3, 16, and 17, encodes isoform 3.
    Source sequence(s)
    AC067817
    Consensus CDS
    CCDS55224.1
    Conserved Domains (1) summary
    pfam05010
    Location:404603
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  18. NM_001352792.2NP_001339721.1  transforming acidic coiled-coil-containing protein 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS87602.1
    Related
    ENSP00000428687.1, ENST00000519416.5
    Conserved Domains (1) summary
    pfam05010
    Location:403602
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  19. NM_001352793.2NP_001339722.1  transforming acidic coiled-coil-containing protein 1 isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variant 21, encodes isoform 17.
    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:404602
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  20. NM_001352794.2NP_001339723.1  transforming acidic coiled-coil-containing protein 1 isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variant 20, encodes isoform 17.
    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:404602
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  21. NM_001352795.2NP_001339724.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 4 and 23-25, encodes isoform 4.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS83284.1
    Conserved Domains (1) summary
    pfam05010
    Location:375574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  22. NM_001352796.2NP_001339725.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 4, 22, 24, and 25, encodes isoform 4.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS83284.1
    Conserved Domains (1) summary
    pfam05010
    Location:375574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  23. NM_001352797.2NP_001339726.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 4, 22, 23, and 25, encodes isoform 4.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS83284.1
    Conserved Domains (1) summary
    pfam05010
    Location:375574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  24. NM_001352798.1NP_001339727.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 4 and 22-24, encodes isoform 4.
    Source sequence(s)
    AC067817
    Consensus CDS
    CCDS83284.1
    Related
    ENSP00000430959.1, ENST00000520973.5
    Conserved Domains (1) summary
    pfam05010
    Location:375574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  25. NM_001352799.2NP_001339728.1  transforming acidic coiled-coil-containing protein 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Related
    ENSP00000428253.1, ENST00000521866.5
    Conserved Domains (1) summary
    pfam05010
    Location:375573
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  26. NM_001352800.2NP_001339729.1  transforming acidic coiled-coil-containing protein 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC067817
  27. NM_001352801.2NP_001339730.1  transforming acidic coiled-coil-containing protein 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:172371
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  28. NM_001352802.1NP_001339731.1  transforming acidic coiled-coil-containing protein 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Related
    ENST00000522955.5
  29. NM_001352803.2NP_001339732.1  transforming acidic coiled-coil-containing protein 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:160359
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  30. NM_001352804.2NP_001339733.1  transforming acidic coiled-coil-containing protein 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:132331
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  31. NM_006283.3NP_006274.2  transforming acidic coiled-coil-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006274.2

    Status: REVIEWED

    Source sequence(s)
    AF049910, AY072876, AY139007, DB084271
    Consensus CDS
    CCDS6109.1
    UniProtKB/Swiss-Prot
    O75410
    Related
    ENSP00000321703.4, ENST00000317827.9
    Conserved Domains (3) summary
    pfam05010
    Location:599798
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:704797
    FadA; Adhesion protein FadA
    cl21478
    Location:610691
    ATP-synt_B; ATP synthase B/B' CF(0)

RNA

  1. NR_148047.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813
  2. NR_148048.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813
  3. NR_148049.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
  4. NR_148050.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
  5. NR_148051.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
  6. NR_148052.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813
  7. NR_148053.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    38728205..38853028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544632.2XP_011542934.1  transforming acidic coiled-coil-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011542934.1

    UniProtKB/Swiss-Prot
    O75410
    Conserved Domains (1) summary
    pfam05010
    Location:611810
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  2. XM_005273625.4XP_005273682.1  transforming acidic coiled-coil-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005273682.1

    UniProtKB/Swiss-Prot
    O75410
    Conserved Domains (1) summary
    pfam05010
    Location:611810
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  3. XM_005273629.1XP_005273686.1  transforming acidic coiled-coil-containing protein 1 isoform X3

    Conserved Domains (3) summary
    pfam05010
    Location:575774
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:680773
    FadA; Adhesion protein FadA
    cl21478
    Location:586667
    ATP-synt_B; ATP synthase B/B' CF(0)
  4. XM_011544636.2XP_011542938.1  transforming acidic coiled-coil-containing protein 1 isoform X5

    UniProtKB/Swiss-Prot
    O75410
    Conserved Domains (2) summary
    pfam05010
    Location:161360
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:271359
    FadA; Adhesion protein FadA
  5. XM_005273628.1XP_005273685.1  transforming acidic coiled-coil-containing protein 1 isoform X2

    Conserved Domains (3) summary
    pfam05010
    Location:583782
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:688781
    FadA; Adhesion protein FadA
    cl21478
    Location:594675
    ATP-synt_B; ATP synthase B/B' CF(0)
  6. XM_011544635.1XP_011542937.1  transforming acidic coiled-coil-containing protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011542937.1

    Conserved Domains (1) summary
    pfam05010
    Location:416615
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
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