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TACC1 transforming acidic coiled-coil containing protein 1 [ Homo sapiens (human) ]

Gene ID: 6867, updated on 6-Sep-2022

Summary

Official Symbol
TACC1provided by HGNC
Official Full Name
transforming acidic coiled-coil containing protein 1provided by HGNC
Primary source
HGNC:HGNC:11522
See related
Ensembl:ENSG00000147526 MIM:605301; AllianceGenome:HGNC:11522
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ga55
Summary
This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Expression
Ubiquitous expression in fat (RPKM 59.1), endometrium (RPKM 38.3) and 24 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See TACC1 in Genome Data Viewer
Location:
8p11.22
Exon count:
23
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (38728582..38853028)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (39005551..39130036)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38586100..38710546)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 5 pseudogene 1 Neighboring gene uncharacterized LOC124901936 Neighboring gene Sharpr-MPRA regulatory region 10821 Neighboring gene Sharpr-MPRA regulatory region 13542 Neighboring gene uncharacterized LOC124901937 Neighboring gene pleckstrin homology domain containing A2 Neighboring gene Sharpr-MPRA regulatory region 15086 Neighboring gene HtrA serine peptidase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42304, KIAA1103, DKFZp686K18126

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
located_in midbody IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transforming acidic coiled-coil-containing protein 1
Names
gastric cancer antigen Ga55
taxin-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122824.2NP_001116296.1  transforming acidic coiled-coil-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001116296.1

    Status: REVIEWED

    Source sequence(s)
    AY139007, AY177411, DB084271
    Consensus CDS
    CCDS47845.1
    UniProtKB/Swiss-Prot
    O75410
    Related
    ENSP00000276520.8, ENST00000276520.12
    Conserved Domains (1) summary
    pfam05010
    Location:189388
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  2. NM_001146216.3NP_001139688.1  transforming acidic coiled-coil-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 16-18, encodes isoform 3.
    Source sequence(s)
    AB029026, AC067817, AY072876, BX647696
    Consensus CDS
    CCDS55224.1
    UniProtKB/Swiss-Prot
    O75410
    UniProtKB/TrEMBL
    Q5HYH0
    Related
    ENSP00000428450.1, ENST00000520615.5
    Conserved Domains (1) summary
    pfam05010
    Location:404603
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  3. NM_001330521.2NP_001317450.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 22-25, encodes isoform 4.
    Source sequence(s)
    AC067817, AI129797, BQ001033, DA152500, DA553264
    Consensus CDS
    CCDS83284.1
    UniProtKB/TrEMBL
    E7EVI4, Q5HYH0
    Conserved Domains (1) summary
    pfam05010
    Location:375574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  4. NM_001352778.2NP_001339707.1  transforming acidic coiled-coil-containing protein 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:615814
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  5. NM_001352779.2NP_001339708.1  transforming acidic coiled-coil-containing protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:611810
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  6. NM_001352780.2NP_001339709.1  transforming acidic coiled-coil-containing protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:586785
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  7. NM_001352781.2NP_001339710.1  transforming acidic coiled-coil-containing protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:582781
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  8. NM_001352782.2NP_001339711.1  transforming acidic coiled-coil-containing protein 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:571770
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  9. NM_001352783.2NP_001339712.1  transforming acidic coiled-coil-containing protein 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:570769
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  10. NM_001352784.2NP_001339713.1  transforming acidic coiled-coil-containing protein 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:542741
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  11. NM_001352785.2NP_001339714.1  transforming acidic coiled-coil-containing protein 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:534733
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  12. NM_001352786.2NP_001339715.1  transforming acidic coiled-coil-containing protein 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS87601.1
    Related
    ENSP00000428706.1, ENST00000518415.5
    Conserved Domains (1) summary
    pfam05010
    Location:525724
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  13. NM_001352787.2NP_001339716.1  transforming acidic coiled-coil-containing protein 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:563762
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  14. NM_001352788.2NP_001339717.1  transforming acidic coiled-coil-containing protein 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:416615
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  15. NM_001352789.2NP_001339718.1  transforming acidic coiled-coil-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 3, 17, and 18, encodes isoform 3.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS55224.1
    Conserved Domains (1) summary
    pfam05010
    Location:404603
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  16. NM_001352790.2NP_001339719.1  transforming acidic coiled-coil-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 3, 16, and 18, encodes isoform 3.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS55224.1
    Conserved Domains (1) summary
    pfam05010
    Location:404603
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  17. NM_001352791.1NP_001339720.1  transforming acidic coiled-coil-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 3, 16, and 17, encodes isoform 3.
    Source sequence(s)
    AC067817
    Consensus CDS
    CCDS55224.1
    Conserved Domains (1) summary
    pfam05010
    Location:404603
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  18. NM_001352792.2NP_001339721.1  transforming acidic coiled-coil-containing protein 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS87602.1
    UniProtKB/TrEMBL
    E7ET87
    Related
    ENSP00000428687.1, ENST00000519416.5
    Conserved Domains (1) summary
    pfam05010
    Location:403602
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  19. NM_001352793.2NP_001339722.1  transforming acidic coiled-coil-containing protein 1 isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variant 21, encodes isoform 17.
    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:404602
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  20. NM_001352794.2NP_001339723.1  transforming acidic coiled-coil-containing protein 1 isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variant 20, encodes isoform 17.
    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:404602
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  21. NM_001352795.2NP_001339724.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 4 and 23-25, encodes isoform 4.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS83284.1
    UniProtKB/TrEMBL
    E7EVI4
    Conserved Domains (1) summary
    pfam05010
    Location:375574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  22. NM_001352796.2NP_001339725.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 4, 22, 24, and 25, encodes isoform 4.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS83284.1
    UniProtKB/TrEMBL
    E7EVI4
    Conserved Domains (1) summary
    pfam05010
    Location:375574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  23. NM_001352797.2NP_001339726.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 4, 22, 23, and 25, encodes isoform 4.
    Source sequence(s)
    AC016813, AC067817
    Consensus CDS
    CCDS83284.1
    UniProtKB/TrEMBL
    E7EVI4
    Conserved Domains (1) summary
    pfam05010
    Location:375574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  24. NM_001352798.1NP_001339727.1  transforming acidic coiled-coil-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 4 and 22-24, encodes isoform 4.
    Source sequence(s)
    AC067817
    Consensus CDS
    CCDS83284.1
    UniProtKB/TrEMBL
    E7EVI4
    Related
    ENSP00000430959.1, ENST00000520973.5
    Conserved Domains (1) summary
    pfam05010
    Location:375574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  25. NM_001352799.2NP_001339728.1  transforming acidic coiled-coil-containing protein 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:375573
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  26. NM_001352800.2NP_001339729.1  transforming acidic coiled-coil-containing protein 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC067817
  27. NM_001352801.2NP_001339730.1  transforming acidic coiled-coil-containing protein 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:172371
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  28. NM_001352802.1NP_001339731.1  transforming acidic coiled-coil-containing protein 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC067817
    UniProtKB/TrEMBL
    B7Z3G3
    Related
    ENST00000522955.5
  29. NM_001352803.2NP_001339732.1  transforming acidic coiled-coil-containing protein 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:160359
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  30. NM_001352804.2NP_001339733.1  transforming acidic coiled-coil-containing protein 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
    Conserved Domains (1) summary
    pfam05010
    Location:132331
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  31. NM_006283.3NP_006274.2  transforming acidic coiled-coil-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006274.2

    Status: REVIEWED

    Source sequence(s)
    AF049910, AY072876, AY139007, DB084271
    Consensus CDS
    CCDS6109.1
    UniProtKB/Swiss-Prot
    O75410, Q9UPP9
    Related
    ENSP00000321703.4, ENST00000317827.9
    Conserved Domains (3) summary
    pfam05010
    Location:599798
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:704797
    FadA; Adhesion protein FadA
    cl21478
    Location:610691
    ATP-synt_B; ATP synthase B/B' CF(0)

RNA

  1. NR_148047.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813
  2. NR_148048.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813
  3. NR_148049.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
  4. NR_148050.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
  5. NR_148051.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813, AC067817
  6. NR_148052.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813
  7. NR_148053.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016813

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    38728582..38853028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422141.1XP_047278097.1  transforming acidic coiled-coil-containing protein 1 isoform X3

  2. XM_047422142.1XP_047278098.1  transforming acidic coiled-coil-containing protein 1 isoform X4

  3. XM_047422145.1XP_047278101.1  transforming acidic coiled-coil-containing protein 1 isoform X8

  4. XM_005273629.2XP_005273686.1  transforming acidic coiled-coil-containing protein 1 isoform X7

    Conserved Domains (3) summary
    pfam05010
    Location:575774
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:680773
    FadA; Adhesion protein FadA
    cl21478
    Location:586667
    ATP-synt_B; ATP synthase B/B' CF(0)
  5. XM_011544632.3XP_011542934.1  transforming acidic coiled-coil-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011542934.1

    UniProtKB/Swiss-Prot
    O75410
    Conserved Domains (1) summary
    pfam05010
    Location:611810
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  6. XM_047422147.1XP_047278103.1  transforming acidic coiled-coil-containing protein 1 isoform X10

  7. XM_047422140.1XP_047278096.1  transforming acidic coiled-coil-containing protein 1 isoform X1

  8. XM_047422144.1XP_047278100.1  transforming acidic coiled-coil-containing protein 1 isoform X5

  9. XM_005273625.5XP_005273682.1  transforming acidic coiled-coil-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005273682.1

    UniProtKB/Swiss-Prot
    O75410
    Conserved Domains (1) summary
    pfam05010
    Location:611810
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  10. XM_047422149.1XP_047278105.1  transforming acidic coiled-coil-containing protein 1 isoform X10

    Related
    ENSP00000428253.1, ENST00000521866.5
  11. XM_047422138.1XP_047278094.1  transforming acidic coiled-coil-containing protein 1 isoform X1

  12. XM_047422139.1XP_047278095.1  transforming acidic coiled-coil-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9UPP9
  13. XM_047422143.1XP_047278099.1  transforming acidic coiled-coil-containing protein 1 isoform X5

  14. XM_047422148.1XP_047278104.1  transforming acidic coiled-coil-containing protein 1 isoform X10

  15. XM_005273628.2XP_005273685.1  transforming acidic coiled-coil-containing protein 1 isoform X6

    Conserved Domains (3) summary
    pfam05010
    Location:583782
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:688781
    FadA; Adhesion protein FadA
    cl21478
    Location:594675
    ATP-synt_B; ATP synthase B/B' CF(0)
  16. XM_047422146.1XP_047278102.1  transforming acidic coiled-coil-containing protein 1 isoform X9

  17. XM_047422150.1XP_047278106.1  transforming acidic coiled-coil-containing protein 1 isoform X10

  18. XM_011544636.3XP_011542938.1  transforming acidic coiled-coil-containing protein 1 isoform X12

    UniProtKB/Swiss-Prot
    O75410
    Conserved Domains (2) summary
    pfam05010
    Location:161360
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:271359
    FadA; Adhesion protein FadA
  19. XM_047422151.1XP_047278107.1  transforming acidic coiled-coil-containing protein 1 isoform X11

    UniProtKB/TrEMBL
    E7EVI4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    39005551..39130036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)