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Cep95 centrosomal protein 95 [ Mus musculus (house mouse) ]

Gene ID: 320162, updated on 2-Nov-2024

Summary

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Official Symbol
Cep95provided by MGI
Official Full Name
centrosomal protein 95provided by MGI
Primary source
MGI:MGI:2443502
See related
Ensembl:ENSMUSG00000018372 AllianceGenome:MGI:2443502
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc45; AI118346; 4732496G21Rik; D330027A14Rik; F630025I20Rik
Summary
Predicted to be located in centrosome. Predicted to be active in spindle pole. Orthologous to human CEP95 (centrosomal protein 95). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 9.1), CNS E11.5 (RPKM 8.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Cep95 in Genome Data Viewer
Location:
11 E1; 11 70.02 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106679466..106709687)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106788640..106818861)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene STARR-seq mESC enhancer starr_30947 Neighboring gene STARR-seq mESC enhancer starr_30948 Neighboring gene polymerase (DNA directed), gamma 2, accessory subunit Neighboring gene microRNA 3064 Neighboring gene DEAD box helicase 5 Neighboring gene SMAD specific E3 ubiquitin protein ligase 2 Neighboring gene STARR-positive B cell enhancer ABC_E11496 Neighboring gene STARR-positive B cell enhancer ABC_E8465 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106822918-106823220 Neighboring gene Smad nuclear interacting protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The genetic program of hematopoietic stem cells. Phillips RL, et al. Science, 2000 Jun 2. PMID 10834841
  2. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
centrosomal protein of 95 kDa
Names
coiled-coil domain containing 45
coiled-coil domain-containing protein 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166685.1 → NP_001160157.1  centrosomal protein of 95 kDa isoform 2

    See identical proteins and their annotated locations for NP_001160157.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon but maintains the reading frame compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK052705, BC090675, BE852789, BU695983
    Consensus CDS
    CCDS48963.1
    UniProtKB/TrEMBL
    Q14B65
    Related
    ENSMUSP00000099357.4, ENSMUST00000103068.10
    Conserved Domains (1) summary
    TIGR02168
    Location:541 → 773
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_177088.3 → NP_796062.2  centrosomal protein of 95 kDa isoform 1

    See identical proteins and their annotated locations for NP_796062.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK052705, BC090675, BE852789, BU695983
    Consensus CDS
    CCDS25563.1
    UniProtKB/Swiss-Prot
    A2A5Z8, Q8BVV7
    Related
    ENSMUSP00000018516.5, ENSMUST00000018516.11
    Conserved Domains (2) summary
    PHA03307
    Location:191 → 360
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02168
    Location:584 → 816
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    106679466..106709687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314609.2 → XP_017170098.1  centrosomal protein of 95 kDa isoform X3

    UniProtKB/TrEMBL
    Q8BWE9
    Conserved Domains (1) summary
    cl00030
    Location:7 → 97
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  2. XM_006533544.4 → XP_006533607.1  centrosomal protein of 95 kDa isoform X1

    Conserved Domains (3) summary
    PHA03307
    Location:191 → 360
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02168
    Location:541 → 773
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl00030
    Location:7 → 97
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  3. XM_036156765.1 → XP_036012658.1  centrosomal protein of 95 kDa isoform X2

    Conserved Domains (4) summary
    PHA03307
    Location:191 → 360
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02168
    Location:486 → 718
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam19016
    Location:55 → 107
    DUF5745; Domain of unknown function (DUF5745)
    cl00030
    Location:7 → 97
    CH_SF; calponin homology (CH) domain superfamily

RNA

  1. XR_879703.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVV7.2 GenPept UniProtKB/Swiss-Prot:Q8BVV7

Gene LinkOut

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