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CEP95 centrosomal protein 95 [ Homo sapiens (human) ]

Gene ID: 90799, updated on 7-Jun-2020

Summary

Official Symbol
CEP95provided by HGNC
Official Full Name
centrosomal protein 95provided by HGNC
Primary source
HGNC:HGNC:25141
See related
Ensembl:ENSG00000258890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCDC45
Expression
Ubiquitous expression in testis (RPKM 9.3), bone marrow (RPKM 8.3) and 25 other tissues See more
Orthologs

Genomic context

See CEP95 in Genome Data Viewer
Location:
17q23.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (64506760..64537951)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62502878..62534069)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene microRNA 3064 Neighboring gene microRNA 5047 Neighboring gene DEAD-box helicase 5 Neighboring gene SMAD specific E3 ubiquitin protein ligase 2 Neighboring gene MICOS10 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp667E1824

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centrosomal protein of 95 kDa
Names
centrosomal protein 95kDa
coiled-coil domain containing 45
coiled-coil domain-containing protein 45

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316990.2NP_001303919.1  centrosomal protein of 95 kDa isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1, that causes translation initiation at a downstream AUG. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK297409, BC009518, BP357015
    UniProtKB/Swiss-Prot
    Q96GE4
    Conserved Domains (1) summary
    cl23720
    Location:540644
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_138363.3NP_612372.1  centrosomal protein of 95 kDa isoform 1

    See identical proteins and their annotated locations for NP_612372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC009518, BP357015
    Consensus CDS
    CCDS45763.1
    UniProtKB/Swiss-Prot
    Q96GE4
    Related
    ENSP00000450461.2, ENST00000556440.7
    Conserved Domains (2) summary
    cl00030
    Location:797
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl25732
    Location:592808
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_133644.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL832822, BC009518, BP357015
    Related
    ENST00000553956.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    64506760..64537951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257779.3XP_005257836.1  centrosomal protein of 95 kDa isoform X1

    Conserved Domains (1) summary
    pfam13868
    Location:584771
    TPH; Trichohyalin-plectin-homology domain
  2. XM_011525458.2XP_011523760.1  centrosomal protein of 95 kDa isoform X5

    Conserved Domains (1) summary
    TIGR00604
    Location:33127
    rad3; DNA repair helicase (rad3)
  3. XM_017025287.1XP_016880776.1  centrosomal protein of 95 kDa isoform X3

    Conserved Domains (1) summary
    TIGR02168
    Location:423597
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  4. XM_005257780.2XP_005257837.1  centrosomal protein of 95 kDa isoform X3

    See identical proteins and their annotated locations for XP_005257837.1

    Conserved Domains (1) summary
    TIGR02168
    Location:423597
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  5. XM_024451020.1XP_024306788.1  centrosomal protein of 95 kDa isoform X2

    Conserved Domains (1) summary
    cl25732
    Location:469643
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_006722166.4XP_006722229.1  centrosomal protein of 95 kDa isoform X4

    See identical proteins and their annotated locations for XP_006722229.1

    Conserved Domains (1) summary
    TIGR02168
    Location:375549
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  7. XM_017025288.2XP_016880777.1  centrosomal protein of 95 kDa isoform X4

    Conserved Domains (1) summary
    TIGR02168
    Location:375549
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_001752675.1 RNA Sequence

  2. XR_002958084.1 RNA Sequence

  3. XR_002958083.1 RNA Sequence

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