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Hist3h2a histone cluster 3, H2a [ Mus musculus (house mouse) ]

Gene ID: 319162, updated on 7-May-2017
Official Symbol
Hist3h2aprovided by MGI
Official Full Name
histone cluster 3, H2aprovided by MGI
Primary source
MGI:MGI:2448458
See related
Ensembl:ENSMUSG00000078851 Vega:OTTMUSG00000011797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]
Orthologs
Location:
11; 11 B1.3
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (58954685..58955192)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (58768187..58770176)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene histone cluster 3, H2ba Neighboring gene histone cluster 3, H2bb, pseudogene Neighboring gene tripartite motif-containing 17 Neighboring gene predicted gene 12260 Neighboring gene predicted gene, 39828

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
UV-damage excision repair ISO
Inferred from Sequence Orthology
more info
 
chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleosome disassembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
nuclear nucleosome ISO
Inferred from Sequence Orthology
more info
 
nucleosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
histone H2A type 3
Names
histone 3, H2a

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178218.4NP_835736.1  histone H2A type 3

    See identical proteins and their annotated locations for NP_835736.1

    Status: REVIEWED

    Source sequence(s)
    AL662809
    Consensus CDS
    CCDS24755.1
    UniProtKB/Swiss-Prot
    Q8BFU2
    UniProtKB/TrEMBL
    A2AB79
    Related
    ENSMUSP00000104445.3, OTTMUSP00000012582, ENSMUST00000108817.4, OTTMUST00000027691
    Conserved Domains (2) summary
    PTZ00017
    Location:1130
    PTZ00017; histone H2A; Provisional
    cd00074
    Location:6120
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    58954685..58955192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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