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H2AW H2A.W histone [ Homo sapiens (human) ]

Gene ID: 92815, updated on 18-Aug-2020

Summary

Official Symbol
H2AWprovided by HGNC
Official Full Name
H2A.W histoneprovided by HGNC
Primary source
HGNC:HGNC:20507
See related
Ensembl:ENSG00000181218 MIM:615015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIST3H2A
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Orthologs

Genomic context

See H2AW in Genome Data Viewer
Location:
1q42.13
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (228457364..228457873, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228645065..228645560, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3.4 histone Neighboring gene ribosomal protein L23a pseudogene 15 Neighboring gene H2B.U histone 1 Neighboring gene microRNA 4666a

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3165

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
UV-damage excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear nucleosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H2A type 3
Names
histone 3, H2a
histone cluster 3 H2A
histone cluster 3, H2a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033445.3NP_254280.1  histone H2A type 3

    See identical proteins and their annotated locations for NP_254280.1

    Status: REVIEWED

    Source sequence(s)
    AL139288
    Consensus CDS
    CCDS1573.1
    UniProtKB/Swiss-Prot
    Q7L7L0
    Related
    ENSP00000355656.2, ENST00000366695.3
    Conserved Domains (1) summary
    PTZ00017
    Location:1130
    PTZ00017; histone H2A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    228457364..228457873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654708.1 Reference GRCh38.p13 PATCHES

    Range
    48563..49072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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