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H3c3 H3 clustered histone 3 [ Mus musculus (house mouse) ]

Gene ID: 319148, updated on 8-Feb-2024

Summary

Official Symbol
H3c3provided by MGI
Official Full Name
H3 clustered histone 3provided by MGI
Primary source
MGI:MGI:2448320
See related
Ensembl:ENSMUSG00000069310 AllianceGenome:MGI:2448320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H3c2; H3c4; H3c6; H3c7; H3c13; H3c14; H3c15; H3-143; Hist1h3c
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]
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Genomic context

Location:
13 A3.1; 13 9.9 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23929025..23929504, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23745042..23745521, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Hist1h1cR1 erythroid cis-regulatory module Neighboring gene family with sequence similarity 113, member A pseudogene Neighboring gene STARR-seq mESC enhancer starr_33971 Neighboring gene H1.2 linker histone, cluster member Neighboring gene STARR-seq mESC enhancer starr_33972 Neighboring gene STARR-positive B cell enhancer ABC_E1162 Neighboring gene STARR-positive B cell enhancer ABC_E210 Neighboring gene H2A clustered histone 5, pseudogene Neighboring gene H2B clustered histone 3

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone H3.2
Names
H3-clustered histone 13
H3-clustered histone 14
H3-clustered histone 15
H3-clustered histone 2
H3-clustered histone 4
H3-clustered histone 6
H3-clustered histone 7
histone cluster 1, H3c
histone1, H3c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175653.2NP_783584.1  histone H3.2

    See identical proteins and their annotated locations for NP_783584.1

    Status: REVIEWED

    Source sequence(s)
    AL590388
    Consensus CDS
    CCDS26362.1
    UniProtKB/Swiss-Prot
    A3KMN6, P84228, Q60582, Q78E59, Q8CGN9
    UniProtKB/TrEMBL
    A1L0V4, B9EI85
    Related
    ENSMUSP00000089346.3, ENSMUST00000091752.5
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    23929025..23929504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)