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HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 [ Homo sapiens (human) ]

Gene ID: 3189, updated on 11-Sep-2019

Summary

Official Symbol
HNRNPH3provided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein H3provided by HGNC
Primary source
HGNC:HGNC:5043
See related
Ensembl:ENSG00000096746 MIM:602324
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2H9; HNRPH3
Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 44.3), ovary (RPKM 43.6) and 25 other tissues See more
Orthologs

Genomic context

See HNRNPH3 in Genome Data Viewer
Location:
10q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (68331693..68343196)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70091768..70102953)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2640 Neighboring gene keratin 19 pseudogene 4 Neighboring gene phenazine biosynthesis like protein domain containing Neighboring gene Sharpr-MPRA regulatory region 82 Neighboring gene RUN and FYVE domain containing 2 Neighboring gene ribosomal protein L26 pseudogene 29 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene RNA, 5S ribosomal pseudogene 319

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPH3 is increased by RRE PubMed
Tat tat Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
tat HIV-1 Tat is identified to have a physical interaction with heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA processing TAS
Traceable Author Statement
more info
PubMed 
RNA splicing TAS
Traceable Author Statement
more info
PubMed 
epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal complex NAS
Non-traceable Author Statement
more info
PubMed 
spliceosomal complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein H3
Names
heterogeneous nuclear ribonucleoprotein 2H9
hnRNP 2H9
hnRNP H3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322434.1NP_001309363.1  heterogeneous nuclear ribonucleoprotein H3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), along with variants 2H9, 4, and 5, encodes isoform a.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7278.1
    UniProtKB/Swiss-Prot
    P31942
    UniProtKB/TrEMBL
    A0A024QZK8
    Conserved Domains (2) summary
    cd12732
    Location:193
    RRM2_hnRNPH3; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12735
    Location:195269
    RRM3_hnRNPH3; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
  2. NM_001322436.1NP_001309365.1  heterogeneous nuclear ribonucleoprotein H3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), along with variants 2H9, 3, and 5, encodes isoform a.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7278.1
    UniProtKB/Swiss-Prot
    P31942
    UniProtKB/TrEMBL
    A0A024QZK8
    Conserved Domains (2) summary
    cd12732
    Location:193
    RRM2_hnRNPH3; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12735
    Location:195269
    RRM3_hnRNPH3; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
  3. NM_001322437.1NP_001309366.1  heterogeneous nuclear ribonucleoprotein H3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), along with variants 2H9, 3, and 4, encodes isoform a.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7278.1
    UniProtKB/Swiss-Prot
    P31942
    UniProtKB/TrEMBL
    A0A024QZK8
    Conserved Domains (2) summary
    cd12732
    Location:193
    RRM2_hnRNPH3; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12735
    Location:195269
    RRM3_hnRNPH3; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
  4. NM_001322438.1NP_001309367.1  heterogeneous nuclear ribonucleoprotein H3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), along with variants 2H9A, 7, 8, and 9, encodes isoform b.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7279.1
    UniProtKB/Swiss-Prot
    P31942
    Conserved Domains (2) summary
    cd12732
    Location:193
    RRM2_hnRNPH3; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12735
    Location:180254
    RRM3_hnRNPH3; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
  5. NM_001322439.1NP_001309368.1  heterogeneous nuclear ribonucleoprotein H3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), along with variants 2H9A, 6, 8, and 9, encodes isoform b.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7279.1
    UniProtKB/Swiss-Prot
    P31942
    Conserved Domains (2) summary
    cd12732
    Location:193
    RRM2_hnRNPH3; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12735
    Location:180254
    RRM3_hnRNPH3; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
  6. NM_001322440.1NP_001309369.1  heterogeneous nuclear ribonucleoprotein H3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), along with variants 2H9A, 6, 7, and 9, encodes isoform b.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7279.1
    UniProtKB/Swiss-Prot
    P31942
    Conserved Domains (2) summary
    cd12732
    Location:193
    RRM2_hnRNPH3; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12735
    Location:180254
    RRM3_hnRNPH3; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
  7. NM_001322441.1NP_001309370.1  heterogeneous nuclear ribonucleoprotein H3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), along with variants 2H9A, 6, 7, and 8, encodes isoform b.
    Source sequence(s)
    AC016395
    Consensus CDS
    CCDS7279.1
    UniProtKB/Swiss-Prot
    P31942
    Conserved Domains (2) summary
    cd12732
    Location:193
    RRM2_hnRNPH3; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12735
    Location:180254
    RRM3_hnRNPH3; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
  8. NM_001322442.1NP_001309371.1  heterogeneous nuclear ribonucleoprotein H3 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) and variant 11 both encode the same isoform (c).
    Source sequence(s)
    AC016395
    Conserved Domains (2) summary
    cd12732
    Location:193
    RRM2_hnRNPH3; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12735
    Location:189263
    RRM3_hnRNPH3; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
  9. NM_001322443.1NP_001309372.1  heterogeneous nuclear ribonucleoprotein H3 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) and variant 10 both encode the same isoform (c).
    Source sequence(s)
    AC016395
    Conserved Domains (2) summary
    cd12732
    Location:193
    RRM2_hnRNPH3; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12735
    Location:189263
    RRM3_hnRNPH3; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
  10. NM_001322444.1NP_001309373.1  heterogeneous nuclear ribonucleoprotein H3 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC016395
    UniProtKB/TrEMBL
    B4DHY1
    Conserved Domains (1) summary
    cd12735
    Location:87161
    RRM3_hnRNPH3; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
  11. NM_001322445.1NP_001309374.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), along with variants 14, 15, 16, and 17, encodes isoform e.
    Source sequence(s)
    AC016395
    UniProtKB/Swiss-Prot
    P31942
    UniProtKB/TrEMBL
    A0A024QZP1
    Conserved Domains (1) summary
    cl17169
    Location:64138
    RRM_SF; RNA recognition motif (RRM) superfamily
  12. NM_001322446.1NP_001309375.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), along with variants 13, 15, 16, and 17, encodes isoform e.
    Source sequence(s)
    AC016395
    UniProtKB/Swiss-Prot
    P31942
    UniProtKB/TrEMBL
    A0A024QZP1
    Conserved Domains (1) summary
    cl17169
    Location:64138
    RRM_SF; RNA recognition motif (RRM) superfamily
  13. NM_001322447.1NP_001309376.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), along with variants 13, 14, 16, and 17, encodes isoform e.
    Source sequence(s)
    AC016395
    UniProtKB/Swiss-Prot
    P31942
    UniProtKB/TrEMBL
    A0A024QZP1
    Conserved Domains (1) summary
    cl17169
    Location:64138
    RRM_SF; RNA recognition motif (RRM) superfamily
  14. NM_001322448.1NP_001309377.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), along with variants 13, 14, 15, and 17, encodes isoform e.
    Source sequence(s)
    AC016395
    UniProtKB/Swiss-Prot
    P31942
    UniProtKB/TrEMBL
    A0A024QZP1
    Conserved Domains (1) summary
    cl17169
    Location:64138
    RRM_SF; RNA recognition motif (RRM) superfamily
  15. NM_001322449.1NP_001309378.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), along with variants 13, 14, 15, and 16, encodes isoform e.
    Source sequence(s)
    AC016395
    UniProtKB/Swiss-Prot
    P31942
    UniProtKB/TrEMBL
    A0A024QZP1
    Conserved Domains (1) summary
    cl17169
    Location:64138
    RRM_SF; RNA recognition motif (RRM) superfamily
  16. NM_001322450.1NP_001309379.1  heterogeneous nuclear ribonucleoprotein H3 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC016395
    Conserved Domains (1) summary
    cl17169
    Location:58132
    RRM_SF; RNA recognition motif (RRM) superfamily
  17. NM_001322451.1NP_001309380.1  heterogeneous nuclear ribonucleoprotein H3 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), along with variants 20 and 21, encodes isoform g.
    Source sequence(s)
    AC016395
    Conserved Domains (1) summary
    cl17169
    Location:26100
    RRM_SF; RNA recognition motif (RRM) superfamily
  18. NM_001322452.1NP_001309381.1  heterogeneous nuclear ribonucleoprotein H3 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), along with variants 19 and 21, encodes isoform g.
    Source sequence(s)
    AC016395
    Conserved Domains (1) summary
    cl17169
    Location:26100
    RRM_SF; RNA recognition motif (RRM) superfamily
  19. NM_001322453.1NP_001309382.1  heterogeneous nuclear ribonucleoprotein H3 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), along with variants 19 and 20, encodes isoform g.
    Source sequence(s)
    AC016395
    Conserved Domains (1) summary
    cl17169
    Location:26100
    RRM_SF; RNA recognition motif (RRM) superfamily
  20. NM_012207.2NP_036339.1  heterogeneous nuclear ribonucleoprotein H3 isoform a

    See identical proteins and their annotated locations for NP_036339.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2H9) encodes the longest isoform (a). Variants 2H9, 3, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AF132362, AK223441, AW189387, DA486117
    Consensus CDS
    CCDS7278.1
    UniProtKB/Swiss-Prot
    P31942
    UniProtKB/TrEMBL
    A0A024QZK8, Q53F48
    Related
    ENSP00000265866.7, ENST00000265866.11
    Conserved Domains (2) summary
    cd12732
    Location:193
    RRM2_hnRNPH3; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12735
    Location:195269
    RRM3_hnRNPH3; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
  21. NM_021644.3NP_067676.2  heterogeneous nuclear ribonucleoprotein H3 isoform b

    See identical proteins and their annotated locations for NP_067676.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2H9A) uses an alternative donor splice site at one of the internal coding exons compared to transcript variant 2H9. However, it maintains the reading frame and encodes an isoform (b) that is missing a 15 aa segment compared to isoform a. Variants 2H9A, 6, 7, 8, and 9 all encode the same isoform (b).
    Source sequence(s)
    AW189387, BC039824, DA486117
    Consensus CDS
    CCDS7279.1
    UniProtKB/Swiss-Prot
    P31942
    Related
    ENSP00000346726.5, ENST00000354695.5
    Conserved Domains (2) summary
    cd12732
    Location:193
    RRM2_hnRNPH3; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12735
    Location:180254
    RRM3_hnRNPH3; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    68331693..68343196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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