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HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 [ Homo sapiens (human) ]

Gene ID: 3178, updated on 26-Aug-2018

Summary

Official Symbol
HNRNPA1provided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein A1provided by HGNC
Primary source
HGNC:HGNC:5031
See related
Ensembl:ENSG00000135486 MIM:164017; Vega:OTTHUMG00000169702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UP 1; ALS19; ALS20; HNRPA1; IBMPFD3; HNRPA1L3; hnRNP A1; hnRNP-A1
Summary
This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in ovary (RPKM 647.6), bone marrow (RPKM 364.1) and 25 other tissues See more
Orthologs

Genomic context

See HNRNPA1 in Genome Data Viewer
Location:
12q13.13
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (54280690..54287088)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54674480..54680871)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene microRNA 3198-2 Neighboring gene chromobox 5 Neighboring gene RNA, 7SL, cytoplasmic 390, pseudogene Neighboring gene nuclear factor, erythroid 2 Neighboring gene RNA, U6 small nuclear 950, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
env Depletion of hnRNP A1 and A2 increase expression of viral structural proteins Gag, Env, and gp120 PubMed
Envelope surface glycoprotein gp160, precursor env Depletion of hnRNP A1 and A2 increase expression of viral structural proteins Gag, Env, and gp120 PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
gag Depletion of hnRNP A1 and A2 increase expression of viral structural proteins Gag, Env, and gp120 PubMed
Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPA1 is increased by RRE PubMed
rev HIV-1 Rev interacts with the heterogeneous nuclear ribonucleoproteins (hnRNP) A1. The amino acids 9-14 in Rev and the arginine residues within the RGG box (amino acids 191-238) of hnRNP A1 are required for the interaction between Rev and hnRNP A1 PubMed
rev hnRNP A1 modulates Rev expression by controlling HIV-1 mRNA splicing PubMed
rev hnRNP A1 binds to cis-acting repressive (CRS) sequences in HIV-1 RNA suggesting a role for this binding in influencing Rev function PubMed
rev hnRNP A1 binds to an instability (INS) element in the p17gag gene of HIV-1 RNA causing synergistic stimulation of Rev-dependent nuclear export of unspliced HIV-1 mRNA PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) at amino acid residues 181-182 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
    Coregulation of Androgen receptor activity, organism-specific biosystem
    Coregulation of Androgen receptor activity
  • FGFR2 alternative splicing, organism-specific biosystem (from REACTOME)
    FGFR2 alternative splicing, organism-specific biosystemAlternative splicing of the FGFR2 nascent mRNA generates an epithelial specific isoform (FGFR2 IIIb) and a mesenchymal specific isoform (FGFR2 IIIc). The inclusion of exon 8 in FGFR2 IIIb or exon 9 ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by FGFR, organism-specific biosystem (from REACTOME)
    Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102835

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-rich strand telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
pre-mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
single-stranded RNA binding IC
Inferred by Curator
more info
PubMed 
telomeric repeat-containing RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus IC
Inferred by Curator
more info
PubMed 
RNA metabolic process TAS
Traceable Author Statement
more info
 
cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to sodium arsenite IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear export IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein A1
Names
helix-destabilizing protein
heterogeneous nuclear ribonucleoprotein A1B protein
heterogeneous nuclear ribonucleoprotein B2 protein
heterogeneous nuclear ribonucleoprotein core protein A1
hnRNP core protein A1-like 3
nuclear ribonucleoprotein particle A1 protein
putative heterogeneous nuclear ribonucleoprotein A1-like 3
single-strand DNA-binding protein UP1
single-strand RNA-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033830.1 RefSeqGene

    Range
    4987..9543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002136.3NP_002127.1  heterogeneous nuclear ribonucleoprotein A1 isoform a

    See identical proteins and their annotated locations for NP_002127.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as A1) encodes isoform a.
    Source sequence(s)
    BC052296, CD705336, DC358304
    Consensus CDS
    CCDS41793.1
    UniProtKB/Swiss-Prot
    P09651
    UniProtKB/TrEMBL
    A0A024RB53
    Related
    ENSP00000448617.1, OTTHUMP00000241883, ENST00000546500.5, OTTHUMT00000405474
    Conserved Domains (3) summary
    cd12580
    Location:105181
    RRM2_hnRNPA1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
    cd12761
    Location:1292
    RRM1_hnRNPA1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
    pfam11627
    Location:262288
    HnRNPA1; Nuclear factor hnRNPA1
  2. NM_031157.3NP_112420.1  heterogeneous nuclear ribonucleoprotein A1 isoform b

    See identical proteins and their annotated locations for NP_112420.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as A1B) contains an alternate in-frame exon compared to variant 1, resulting in a longer protein (isoform b) than isoform 1.
    Source sequence(s)
    BC052296, BC070315, BU541100, CD705336, DC358304
    Consensus CDS
    CCDS44909.1
    UniProtKB/Swiss-Prot
    P09651
    UniProtKB/TrEMBL
    A0A024RAZ7
    Related
    ENSP00000341826.6, OTTHUMP00000241887, ENST00000340913.10, OTTHUMT00000405480
    Conserved Domains (3) summary
    cd12580
    Location:105181
    RRM2_hnRNPA1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
    cd12761
    Location:1292
    RRM1_hnRNPA1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
    pfam11627
    Location:314340
    HnRNPA1; Nuclear factor hnRNPA1

RNA

  1. NR_135167.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon and contains two alternate 3' terminal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC070315, CD705336, DC358304

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    54280690..54287088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268826.2XP_005268883.1  heterogeneous nuclear ribonucleoprotein A1 isoform X1

    See identical proteins and their annotated locations for XP_005268883.1

    UniProtKB/Swiss-Prot
    P09651
    UniProtKB/TrEMBL
    A0A024RAZ7
    Conserved Domains (3) summary
    cd12580
    Location:105181
    RRM2_hnRNPA1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
    cd12761
    Location:1292
    RRM1_hnRNPA1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
    pfam11627
    Location:314340
    HnRNPA1; Nuclear factor hnRNPA1

RNA

  1. XR_245923.2 RNA Sequence

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