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EIF4E3 eukaryotic translation initiation factor 4E family member 3 [ Homo sapiens (human) ]

Gene ID: 317649, updated on 1-Jun-2020

Summary

Official Symbol
EIF4E3provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4E family member 3provided by HGNC
Primary source
HGNC:HGNC:31837
See related
Ensembl:ENSG00000163412 MIM:609896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
eIF-4E3; eIF4E-3
Summary
EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in fat (RPKM 11.9), brain (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See EIF4E3 in Genome Data Viewer
Location:
3p13
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (71675414..71754773, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71728440..71803924, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene forkhead box P1 Neighboring gene microRNA 1284 Neighboring gene uncharacterized LOC105377155 Neighboring gene uncharacterized LOC105377156 Neighboring gene G protein-coupled receptor 27 Neighboring gene prokineticin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of eukaryotic translation initiation factor 4E family member 3 (EIF4E3) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC39820, MGC86971

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA cap binding complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 4E type 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134649.2NP_001128121.1  eukaryotic translation initiation factor 4E type 3 isoform b

    See identical proteins and their annotated locations for NP_001128121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AC097634, BC068443, DN990553
    Consensus CDS
    CCDS33786.1
    UniProtKB/Swiss-Prot
    Q8N5X7
    Related
    ENSP00000410350.1, ENST00000448225.5
    Conserved Domains (1) summary
    pfam01652
    Location:6102
    IF4E; Eukaryotic initiation factor 4E
  2. NM_001134650.1NP_001128122.1  eukaryotic translation initiation factor 4E type 3 isoform b

    See identical proteins and their annotated locations for NP_001128122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AC097634, AL161983, BC068443, DA227887, DA394405
    Consensus CDS
    CCDS33786.1
    UniProtKB/Swiss-Prot
    Q8N5X7
    Related
    ENSP00000374476.3, ENST00000389826.7
    Conserved Domains (1) summary
    pfam01652
    Location:6102
    IF4E; Eukaryotic initiation factor 4E
  3. NM_001134651.2NP_001128123.1  eukaryotic translation initiation factor 4E type 3 isoform a

    See identical proteins and their annotated locations for NP_001128123.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC097634, AC134770, AK126999, AL161983, DR159502
    Consensus CDS
    CCDS46867.1
    UniProtKB/Swiss-Prot
    Q8N5X7
    Related
    ENSP00000393324.2, ENST00000425534.8
    Conserved Domains (1) summary
    pfam01652
    Location:48198
    IF4E; Eukaryotic initiation factor 4E
  4. NM_001282886.2NP_001269815.1  eukaryotic translation initiation factor 4E type 3 isoform b

    See identical proteins and their annotated locations for NP_001269815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AC096970, AC097634, BC068443
    Consensus CDS
    CCDS33786.1
    UniProtKB/Swiss-Prot
    Q8N5X7
    Related
    ENSP00000295612.3, ENST00000295612.7
    Conserved Domains (1) summary
    pfam01652
    Location:6102
    IF4E; Eukaryotic initiation factor 4E
  5. NM_173359.5NP_775495.1  eukaryotic translation initiation factor 4E type 3 isoform b

    See identical proteins and their annotated locations for NP_775495.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
    Source sequence(s)
    AC097634, AK313656, AL161983, BC068443
    Consensus CDS
    CCDS33786.1
    UniProtKB/Swiss-Prot
    Q8N5X7
    Related
    ENSP00000411762.2, ENST00000421769.6
    Conserved Domains (1) summary
    pfam01652
    Location:6102
    IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    71675414..71754773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006282.2XP_016861771.1  eukaryotic translation initiation factor 4E type 3 isoform X2

    UniProtKB/Swiss-Prot
    Q8N5X7
    Conserved Domains (1) summary
    pfam01652
    Location:6102
    IF4E; Eukaryotic initiation factor 4E
  2. XM_011533651.3XP_011531953.1  eukaryotic translation initiation factor 4E type 3 isoform X1

    Conserved Domains (1) summary
    pfam01652
    Location:51146
    IF4E; Eukaryotic initiation factor 4E
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