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Chordc1 cysteine and histidine rich domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315447, updated on 11-Apr-2024

Summary

Official Symbol
Chordc1provided by RGD
Official Full Name
cysteine and histidine rich domain containing 1provided by RGD
Primary source
RGD:1304679
See related
Ensembl:ENSRNOG00000026643 AllianceGenome:RGD:1304679
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CHP-1
Summary
Predicted to enable Hsp90 protein binding activity; adenyl ribonucleotide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including centrosome duplication; negative regulation of Rho-dependent protein serine/threonine kinase activity; and regulation of centrosome duplication. Orthologous to human CHORDC1 (cysteine and histidine rich domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 269.7), Muscle (RPKM 264.3) and 9 other tissues See more
Orthologs
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Genomic context

See Chordc1 in Genome Data Viewer
Location:
8q13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (23650721..23674786)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (15374356..15398436)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (17421552..17445513)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480000 Neighboring gene DNA methyltransferase 3 alpha, pseudogene 2 Neighboring gene N-acetylated alpha-linked acidic dipeptidase 2 Neighboring gene UBTF like 6, pseudogene1 Neighboring gene upstream binding transcription factor like 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ADP binding IEA
Inferred from Electronic Annotation
more info
 
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
NOT enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in centrosome duplication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chaperone-mediated protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular response to heat ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of centrosome duplication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of centrosome duplication ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cysteine and histidine-rich domain-containing protein 1
Names
CHORD domain-containing protein 1
cysteine and histidine-rich domain (CHORD)-containing 1
cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
morgana

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108128.1NP_001101598.1  cysteine and histidine-rich domain-containing protein 1

    See identical proteins and their annotated locations for NP_001101598.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473993
    UniProtKB/Swiss-Prot
    D4A4T9
    UniProtKB/TrEMBL
    A0A8L2QG05
    Conserved Domains (2) summary
    cd06488
    Location:230316
    p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
    pfam04968
    Location:364
    CHORD; CHORD

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    23650721..23674786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_005487807.2 RNA Sequence