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CHORDC1 cysteine and histidine rich domain containing 1 [ Homo sapiens (human) ]

Gene ID: 26973, updated on 7-Jun-2020

Summary

Official Symbol
CHORDC1provided by HGNC
Official Full Name
cysteine and histidine rich domain containing 1provided by HGNC
Primary source
HGNC:HGNC:14525
See related
Ensembl:ENSG00000110172 MIM:604353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHP1
Expression
Ubiquitous expression in lymph node (RPKM 9.0), appendix (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See CHORDC1 in Genome Data Viewer
Location:
11q14.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (90200429..90223364, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89933597..89956532, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene upstream binding transcription factor like 1 Neighboring gene N-acetylated alpha-linked acidic dipeptidase 2 Neighboring gene DISC1 fusion partner 1 Neighboring gene tubulin alpha pseudogene 2 Neighboring gene microRNA 4490

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cysteine and histidine-rich domain (CHORD) containing 1 (CHORDC1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with cysteine and histidine-rich domain containing 1 (CHORDC1; CHP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37289

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
centrosome duplication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone-mediated protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular response to heat ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
cysteine and histidine-rich domain-containing protein 1
Names
CHORD-containing protein 1
CHP-1
chord domain-containing protein 1
cysteine and histidine-rich domain (CHORD) containing 1
cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
morgana
protein morgana

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144073.1NP_001137545.1  cysteine and histidine-rich domain-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) is shorter compared to isoform a.
    Source sequence(s)
    AF123249, BC072461, CB852298, CF146721, CK300454, DA417105
    Consensus CDS
    CCDS44705.1
    UniProtKB/Swiss-Prot
    Q9UHD1
    Related
    ENSP00000401080.2, ENST00000457199.6
    Conserved Domains (2) summary
    cd06488
    Location:211297
    p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
    pfam04968
    Location:136197
    CHORD; CHORD
  2. NM_012124.3NP_036256.2  cysteine and histidine-rich domain-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_036256.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK290231, BC002339, BC072461, CB852298, CK300454
    Consensus CDS
    CCDS8289.1
    UniProtKB/Swiss-Prot
    Q9UHD1
    Related
    ENSP00000319255.6, ENST00000320585.11
    Conserved Domains (2) summary
    cd06488
    Location:230316
    p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
    pfam04968
    Location:364
    CHORD; CHORD

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    90200429..90223364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017540.2XP_016873029.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd06488
    Location:116202
    p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
    pfam04968
    Location:41102
    CHORD; CHORD
  2. XM_017017541.2XP_016873030.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd06488
    Location:116202
    p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
    pfam04968
    Location:41102
    CHORD; CHORD

RNA

  1. XR_001747832.2 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_019805497.1 Reference GRCh38.p13 PATCHES

    Range
    106552..129487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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