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Fbxl4 F-box and leucine-rich repeat protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313101, updated on 19-Sep-2024

Summary

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Official Symbol
Fbxl4provided by RGD
Official Full Name
F-box and leucine-rich repeat protein 4provided by RGD
Primary source
RGD:1305724
See related
EnsemblRapid:ENSRNOG00000005641 AllianceGenome:RGD:1305724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in mitochondrial intermembrane space and nuclear speck. Predicted to be part of SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 13. Orthologous to human FBXL4 (F-box and leucine rich repeat protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 171.5), Kidney (RPKM 91.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (40752513..40826154)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (35955801..36029446)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (36555061..36628920)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102844 Neighboring gene PEST proteolytic signal containing nuclear protein, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102553820 Neighboring gene POU class 3 homeobox 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in FBXL4, encoding a mitochondrial protein, cause early-onset mitochondrial encephalomyopathy. Gai X, et al. Am J Hum Genet, 2013 Sep 5. PMID 23993194, Free PMC Article
  2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within autophagy of mitochondrion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395576.1 → NP_001382505.1  F-box/LRR-repeat protein 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2JWF5, B1WBR8, F7FMX3
    Related
    ENSRNOP00000057843.2, ENSRNOT00000061128.6
    Conserved Domains (3) summary
    cd09293
    Location:394 → 601
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:347 → 376
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:280 → 318
    F-box-like

  2. NM_001395577.1 → NP_001382506.1  F-box/LRR-repeat protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2JWF5, A0A8I5Y8W0
    Related
    ENSRNOP00000076415.1, ENSRNOT00000102239.2
    Conserved Domains (3) summary
    cd09293
    Location:394 → 577
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:295 → 317
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:280 → 318
    F-box-like

RNA

  1. NR_172642.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    40752513..40826154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593343.2 → XP_017448832.1  F-box/LRR-repeat protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWF5, B1WBR8, F7FMX3
    Conserved Domains (3) summary
    cd09293
    Location:394 → 601
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:347 → 376
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:280 → 318
    F-box-like

  2. XM_063287583.1 → XP_063143653.1  F-box/LRR-repeat protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JWF5, A0A8I5Y8W0

  3. XM_039109815.1 → XP_038965743.1  F-box/LRR-repeat protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWF5, B1WBR8, F7FMX3
    Conserved Domains (3) summary
    cd09293
    Location:394 → 601
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:347 → 376
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:280 → 318
    F-box-like

  4. XM_017593342.2 → XP_017448831.1  F-box/LRR-repeat protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWF5, B1WBR8, F7FMX3
    Conserved Domains (3) summary
    cd09293
    Location:394 → 601
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:347 → 376
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:280 → 318
    F-box-like

  5. XM_063287582.1 → XP_063143652.1  F-box/LRR-repeat protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JWF5, A0A8I5Y8W0
Nucleotide Protein Strain
Heading Accession and Version

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