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Ddx25 DEAD box helicase 25 [ Mus musculus (house mouse) ]

Gene ID: 30959, updated on 1-Mar-2024

Summary

Official Symbol
Ddx25provided by MGI
Official Full Name
DEAD box helicase 25provided by MGI
Primary source
MGI:MGI:1353582
See related
Ensembl:ENSMUSG00000032101 AllianceGenome:MGI:1353582
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GRTH
Summary
Enables ATP binding activity and RNA helicase activity. Involved in mRNA export from nucleus; regulation of translation; and spermatid development. Located in chromatoid body and nucleus. Is expressed in spermatid and spermatocyte. Orthologous to human DDX25 (DEAD-box helicase 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 116.1), CNS E18 (RPKM 19.3) and 5 other tissues See more
Orthologs
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Genomic context

See Ddx25 in Genome Data Viewer
Location:
9 A4; 9 20.31 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35453144..35469766, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35541848..35558470, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cell adhesion molecule-related/down-regulated by oncogenes Neighboring gene predicted gene, 25630 Neighboring gene V-set and immunoglobulin domain containing 10 like 2 Neighboring gene STARR-positive B cell enhancer ABC_E11404 Neighboring gene STARR-positive B cell enhancer ABC_E1782 Neighboring gene pseudouridine synthase 3 Neighboring gene HYLS1, centriolar and ciliogenesis associated Neighboring gene small cell adhesion glycoprotein family member

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermatid development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatoid body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-dependent RNA helicase DDX25
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 25
DEAD box protein 25
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 25
gonadotropin-regulated testicular RNA helicase
NP_038960.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013932.4NP_038960.2  ATP-dependent RNA helicase DDX25

    See identical proteins and their annotated locations for NP_038960.2

    Status: VALIDATED

    Source sequence(s)
    AK078340, CF104207
    Consensus CDS
    CCDS52753.1
    UniProtKB/Swiss-Prot
    Q53Z03, Q7TMB5, Q8R1B6, Q9QY15
    Related
    ENSMUSP00000034612.5, ENSMUST00000034612.7
    Conserved Domains (3) summary
    smart00487
    Location:113316
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:312448
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:112302
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    35453144..35469766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)