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DDX25 DEAD-box helicase 25 [ Homo sapiens (human) ]

Gene ID: 29118, updated on 6-Sep-2021

Summary

Official Symbol
DDX25provided by HGNC
Official Full Name
DEAD-box helicase 25provided by HGNC
Primary source
HGNC:HGNC:18698
See related
Ensembl:ENSG00000109832 MIM:607663
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRTH
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 40.9) See more
Orthologs
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Genomic context

See DDX25 in Genome Data Viewer
Location:
11q24.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (125903328..125928843)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (125773223..125798738)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene prostate and testis expressed 4 Neighboring gene HYLS1 centriolar and ciliogenesis associated Neighboring gene pseudouridine synthase 3 Neighboring gene V-set and immunoglobulin domain containing 10 like 2 Neighboring gene cell adhesion associated, oncogene regulated Neighboring gene VISTA enhancer hs1641

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromatoid body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ATP-dependent RNA helicase DDX25
Names
DEAD (Asp-Glu-Ala-Asp) box helicase 25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
DEAD box protein 25
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 25
epididymis secretory sperm binding protein
gonadotropin-regulated testicular RNA helicase
NP_001317367.1
NP_037396.3
XP_011541092.1
XP_011541093.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330438.2NP_001317367.1  ATP-dependent RNA helicase DDX25 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL520666, AL534333, AP000842
    Consensus CDS
    CCDS81646.1
    UniProtKB/Swiss-Prot
    Q9UHL0
    Related
    ENSP00000490224.1, ENST00000525943.1
    Conserved Domains (2) summary
    cd18787
    Location:198334
    SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
    cl28899
    Location:1194
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  2. NM_013264.5NP_037396.3  ATP-dependent RNA helicase DDX25 isoform 1

    See identical proteins and their annotated locations for NP_037396.3

    Status: REVIEWED

    Source sequence(s)
    AF155140, AL563479, AP000842, BC050360
    Consensus CDS
    CCDS44766.1
    UniProtKB/Swiss-Prot
    Q9UHL0
    Related
    ENSP00000263576.6, ENST00000263576.11
    Conserved Domains (3) summary
    smart00487
    Location:112315
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:311447
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:111301
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    125903328..125928843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542791.3XP_011541093.1  ATP-dependent RNA helicase DDX25 isoform X2

    Related
    ENSP00000463333.1, ENST00000530414.5
    Conserved Domains (3) summary
    smart00487
    Location:111314
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:310446
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:110300
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011542790.3XP_011541092.1  ATP-dependent RNA helicase DDX25 isoform X1

    Related
    ENSP00000436087.1, ENST00000526875.1
    Conserved Domains (3) summary
    smart00487
    Location:115318
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:314450
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:114304
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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