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Mlf2 myeloid leukemia factor 2 [ Mus musculus (house mouse) ]

Gene ID: 30853, updated on 2-Nov-2024

Summary

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Official Symbol
Mlf2provided by MGI
Official Full Name
myeloid leukemia factor 2provided by MGI
Primary source
MGI:MGI:1353554
See related
Ensembl:ENSMUSG00000030120 AllianceGenome:MGI:1353554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus. Is active in glutamatergic synapse. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human MLF2 (myeloid leukemia factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 196.7), adrenal adult (RPKM 170.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mlf2 in Genome Data Viewer
Location:
6 F2; 6 59.17 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124908351..124913112)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124931388..124936149)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A230083G16 gene Neighboring gene STARR-seq mESC enhancer starr_17314 Neighboring gene parathymosin Neighboring gene predicted gene, 38896 Neighboring gene STARR-positive B cell enhancer ABC_E8969 Neighboring gene STARR-seq mESC enhancer starr_17317 Neighboring gene STARR-seq mESC enhancer starr_17318 Neighboring gene STARR-seq mESC enhancer starr_17319 Neighboring gene STARR-positive B cell enhancer ABC_E3682 Neighboring gene COP9 signalosome subunit 7A Neighboring gene predicted gene, 23851 Neighboring gene STARR-seq mESC enhancer starr_17320 Neighboring gene STARR-seq mESC enhancer starr_17322 Neighboring gene PILR alpha associated neural protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Teratogen-induced distortions in the classical NF-kappaB activation pathway: correlation with the ability of embryos to survive teratogenic stress. Molotski N, et al. Toxicol Appl Pharmacol, 2008 Jun 1. PMID 18395765
  2. G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. Zhang D, et al. J Biol Chem, 2008 Mar 28. PMID 18218630, Free PMC Article
  3. Chaperone protein HYPK interacts with the first 17 amino acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity. Choudhury KR, et al. Biochem Biophys Res Commun, 2015 Jan 2. PMID 25446099
  4. SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Koopmans F, et al. Neuron, 2019 Jul 17. PMID 31171447, Free PMC Article
  5. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myeloid leukemia factor 2
Names
Myelodysplasia-myeloid leukemia factor 2
myeloid leukemia factor 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170341.1 → NP_001163812.1  myeloid leukemia factor 2

    See identical proteins and their annotated locations for NP_001163812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AK143972, BF464435, BY286289
    Consensus CDS
    CCDS20538.1
    UniProtKB/Swiss-Prot
    Q99KX1
    UniProtKB/TrEMBL
    Q3UNV7, Q3URS8
    Related
    ENSMUSP00000135920.2, ENSMUST00000180095.4
    Conserved Domains (1) summary
    pfam10248
    Location:26 → 198
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

  2. NM_145385.2 → NP_663360.1  myeloid leukemia factor 2

    See identical proteins and their annotated locations for NP_663360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AK143972, BF464435, BY286289, CD560861
    Consensus CDS
    CCDS20538.1
    UniProtKB/Swiss-Prot
    Q99KX1
    UniProtKB/TrEMBL
    Q3UNV7, Q3URS8
    Related
    ENSMUSP00000032214.8, ENSMUST00000032214.14
    Conserved Domains (1) summary
    pfam10248
    Location:26 → 198
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124908351..124913112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KX1.1 GenPept UniProtKB/Swiss-Prot:Q99KX1

Gene LinkOut

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