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MLF2 myeloid leukemia factor 2 [ Homo sapiens (human) ]

Gene ID: 8079, updated on 8-Aug-2021

Summary

Official Symbol
MLF2provided by HGNC
Official Full Name
myeloid leukemia factor 2provided by HGNC
Primary source
HGNC:HGNC:7126
See related
Ensembl:ENSG00000089693 MIM:601401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTN4
Expression
Ubiquitous expression in brain (RPKM 67.7), prostate (RPKM 51.7) and 25 other tissues See more
Orthologs
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Genomic context

See MLF2 in Genome Data Viewer
Location:
12p13.31
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6747996..6753141, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6857162..6862307, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 781, pseudogene Neighboring gene COP9 signalosome subunit 7A Neighboring gene parathymosin Neighboring gene lymphocyte activating 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
myeloid leukemia factor 2
Names
myelodysplasia-myeloid leukemia factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382225.1NP_001369154.1  myeloid leukemia factor 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 2 and 3, all encode the same protein.
    Source sequence(s)
    AC125494
    Related
    ENSP00000446317.1, ENST00000539187.5
    Conserved Domains (1) summary
    pfam10248
    Location:26199
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  2. NM_001382226.1NP_001369155.1  myeloid leukemia factor 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3, all encode the same protein.
    Source sequence(s)
    AC125494, U57342
    Related
    ENSP00000203630.5, ENST00000203630.10
    Conserved Domains (1) summary
    pfam10248
    Location:26199
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
  3. NM_005439.3NP_005430.1  myeloid leukemia factor 2

    See identical proteins and their annotated locations for NP_005430.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3, all encode the same protein.
    Source sequence(s)
    AK289869, BC002340
    Consensus CDS
    CCDS8559.1
    UniProtKB/Swiss-Prot
    Q15773
    UniProtKB/TrEMBL
    A8K1F4, Q5U0N1
    Related
    ENSP00000403941.1, ENST00000435120.5
    Conserved Domains (1) summary
    pfam10248
    Location:26199
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    6747996..6753141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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