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DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 30836, updated on 4-Oct-2020

Summary

Official Symbol
DNTTIP2provided by HGNC
Official Full Name
deoxynucleotidyltransferase terminal interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:24013
See related
Ensembl:ENSG00000067334 MIM:611199
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERBP; FCF2; TdIF2; HSU15552; LPTS-RP2
Summary
This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 37.4), testis (RPKM 17.8) and 25 other tissues See more
Orthologs

Genomic context

See DNTTIP2 in Genome Data Viewer
Location:
1p22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (93866284..93879206, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (94335014..94345474, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene BCAR3 adaptor protein, NSP family member Neighboring gene tRNA-Arg (anticodon TCT) 1-1 Neighboring gene microRNA 760 Neighboring gene glutamate-cysteine ligase modifier subunit Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ98849, MGC163494

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
deoxynucleotidyltransferase terminal-interacting protein 2
Names
LPTS-interacting protein 2
acidic 82 kDa protein mRNA
estrogen receptor binding protein
tdT-interacting factor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014597.5NP_055412.2  deoxynucleotidyltransferase terminal-interacting protein 2

    See identical proteins and their annotated locations for NP_055412.2

    Status: REVIEWED

    Source sequence(s)
    AA832262, AI436814, AL049796, AU134239
    Consensus CDS
    CCDS44174.1
    UniProtKB/Swiss-Prot
    Q5QJE6
    Related
    ENSP00000411010.2, ENST00000436063.7
    Conserved Domains (1) summary
    pfam08698
    Location:639731
    Fcf2; Fcf2 pre-rRNA processing

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    93866284..93879206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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