Format

Send to:

Choose Destination

ADGRE2 adhesion G protein-coupled receptor E2 [ Homo sapiens (human) ]

Gene ID: 30817, updated on 12-Jan-2019

Summary

Official Symbol
ADGRE2provided by HGNC
Official Full Name
adhesion G protein-coupled receptor E2provided by HGNC
Primary source
HGNC:HGNC:3337
See related
Ensembl:ENSG00000127507 MIM:606100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VBU; CD97; EMR2; CD312
Summary
This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Expression
Broad expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 16 other tissues See more
Orthologs

Genomic context

See ADGRE2 in Genome Data Viewer
Location:
19p13.12
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (14732697..14778541, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14843509..14889353, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E3 Neighboring gene small nucleolar RNA, H/ACA box 104 Neighboring gene integrin subunit beta 1 pseudogene 1 Neighboring gene uncharacterized LOC107985308 Neighboring gene zinc finger protein 333 Neighboring gene transmembrane protein 167A pseudogene Neighboring gene olfactory receptor family 7 subfamily C member 1 Neighboring gene olfactory receptor family 7 subfamily A member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781B135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
chondroitin sulfate binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
granulocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leading edge membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor E2
Names
CD97 antigen
EGF-like module-containing mucin-like hormone receptor-like 2
Leukocyte antigen CD97
egf-like module containing, mucin-like, hormone receptor-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047146.1 RefSeqGene

    Range
    5001..50845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001271052.1NP_001257981.1  adhesion G protein-coupled receptor E2 isoform h precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (h) is shorter than isoform a.
    Source sequence(s)
    AC005327, AC090427, AK298700, BC127004, CN480316
    Consensus CDS
    CCDS59361.1
    UniProtKB/Swiss-Prot
    Q9UHX3
    UniProtKB/TrEMBL
    A0JNV7
    Related
    ENSP00000376692.3, ENST00000392965.7
    Conserved Domains (3) summary
    cd00054
    Location:119154
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:163210
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:475716
    7tm_4; Olfactory receptor
  2. NM_013447.4NP_038475.2  adhesion G protein-coupled receptor E2 isoform a precursor

    See identical proteins and their annotated locations for NP_038475.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC005327, AC090427, AK298700, BC127004, BG721006, CN480316
    Consensus CDS
    CCDS32935.1
    UniProtKB/Swiss-Prot
    Q9UHX3
    UniProtKB/TrEMBL
    A0JNV7
    Related
    ENSP00000319883.3, ENST00000315576.7
    Conserved Domains (4) summary
    smart00303
    Location:479529
    GPS; G-protein-coupled receptor proteolytic site domain
    cd00054
    Location:119154
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:163210
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:533774
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    14732697..14778541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026726.1XP_016882215.1  adhesion G protein-coupled receptor E2 isoform X3

  2. XM_011527954.3XP_011526256.1  adhesion G protein-coupled receptor E2 isoform X8

    Conserved Domains (4) summary
    smart00303
    Location:366416
    GPS; G-protein-coupled receptor proteolytic site domain
    cd00054
    Location:641
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:5097
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:420661
    7tm_4; Olfactory receptor
  3. XM_017026727.1XP_016882216.1  adhesion G protein-coupled receptor E2 isoform X7

  4. XM_011527951.3XP_011526253.1  adhesion G protein-coupled receptor E2 isoform X4

    Related
    ENSP00000470725.1, ENST00000594294.5
    Conserved Domains (4) summary
    smart00303
    Location:430480
    GPS; G-protein-coupled receptor proteolytic site domain
    cd00054
    Location:119154
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:163197
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:484725
    7tm_4; Olfactory receptor
  5. XM_011527949.2XP_011526251.1  adhesion G protein-coupled receptor E2 isoform X2

    Related
    ENSP00000472280.2, ENST00000596991.6
    Conserved Domains (4) summary
    smart00303
    Location:468518
    GPS; G-protein-coupled receptor proteolytic site domain
    cd00054
    Location:119154
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:163210
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:522763
    7tm_4; Olfactory receptor
  6. XM_011527952.3XP_011526254.1  adhesion G protein-coupled receptor E2 isoform X5

    Conserved Domains (3) summary
    cd00054
    Location:119154
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:163210
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:475716
    7tm_4; Olfactory receptor
  7. XM_011527948.2XP_011526250.1  adhesion G protein-coupled receptor E2 isoform X1

    Conserved Domains (4) summary
    smart00303
    Location:479529
    GPS; G-protein-coupled receptor proteolytic site domain
    cd00054
    Location:119154
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:163210
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:533774
    7tm_4; Olfactory receptor
  8. XM_011527953.2XP_011526255.1  adhesion G protein-coupled receptor E2 isoform X6

    Related
    ENSP00000472735.1, ENST00000594076.5
    Conserved Domains (3) summary
    smart00303
    Location:386436
    GPS; G-protein-coupled receptor proteolytic site domain
    pfam07645
    Location:119153
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:440681
    7tm_4; Olfactory receptor
  9. XM_011527955.2XP_011526257.1  adhesion G protein-coupled receptor E2 isoform X9

    Conserved Domains (3) summary
    smart00303
    Location:280330
    GPS; G-protein-coupled receptor proteolytic site domain
    pfam07645
    Location:1347
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:334575
    7tm_4; Olfactory receptor

RNA

  1. XR_936174.1 RNA Sequence

  2. XR_001753675.1 RNA Sequence

  3. XR_936173.1 RNA Sequence

  4. XR_001753674.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152916.1: Suppressed sequence

    Description
    NM_152916.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_152917.1: Suppressed sequence

    Description
    NM_152917.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_152918.1: Suppressed sequence

    Description
    NM_152918.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  4. NM_152919.1: Suppressed sequence

    Description
    NM_152919.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  5. NM_152920.1: Suppressed sequence

    Description
    NM_152920.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  6. NM_152921.1: Suppressed sequence

    Description
    NM_152921.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center