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ADGRE2 adhesion G protein-coupled receptor E2 [ Homo sapiens (human) ]

Gene ID: 30817, updated on 2-Nov-2024

Summary

Official Symbol
ADGRE2provided by HGNC
Official Full Name
adhesion G protein-coupled receptor E2provided by HGNC
Primary source
HGNC:HGNC:3337
See related
Ensembl:ENSG00000127507 MIM:606100; AllianceGenome:HGNC:3337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VBU; CD97; EMR2; CD312
Summary
This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Expression
Broad expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 16 other tissues See more
Orthologs
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Genomic context

See ADGRE2 in Genome Data Viewer
Location:
19p13.12
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (14724171..14778560, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (14850478..14906112, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14843204..14889372, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E3 Neighboring gene small nucleolar RNA, H/ACA box 104 Neighboring gene integrin subunit beta 1 pseudogene 1 Neighboring gene YPEL5 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10263 Neighboring gene zinc finger protein 333 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:14841378-14842577 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14869525-14870048 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14870049-14870574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14884311-14884812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14179 Neighboring gene CRISPRi-validated cis-regulatory element chr19.2424 Neighboring gene TMEM167A pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:14910875-14912074 Neighboring gene olfactory receptor family 7 subfamily C member 1 Neighboring gene olfactory receptor family 7 subfamily A member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp781B135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables chondroitin sulfate binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in leading edge membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor E2
Names
CD97 antigen
EGF-like module-containing mucin-like hormone receptor-like 2
Leukocyte antigen CD97
egf-like module containing, mucin-like, hormone receptor-like 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047146.1 RefSeqGene

    Range
    4982..51150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001271052.1NP_001257981.1  adhesion G protein-coupled receptor E2 isoform h precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (h) is shorter than isoform a.
    Source sequence(s)
    AC005327, AC090427, AK298700, BC127004, CN480316
    Consensus CDS
    CCDS59361.1
    UniProtKB/TrEMBL
    A0JNV7
    Related
    ENSP00000376692.3, ENST00000392965.7
    Conserved Domains (4) summary
    cd00054
    Location:119154
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd15439
    Location:475737
    7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam07645
    Location:212243
    EGF_CA; Calcium-binding EGF domain
    pfam12662
    Location:186215
    cEGF; Complement Clr-like EGF-like
  2. NM_013447.4NP_038475.2  adhesion G protein-coupled receptor E2 isoform a precursor

    See identical proteins and their annotated locations for NP_038475.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC005327, AC090427, AK298700, BC127004, BG721006, CN480316
    Consensus CDS
    CCDS32935.1
    UniProtKB/Swiss-Prot
    B4DQ96, E7ESD7, E9PBR1, E9PEL6, E9PFQ5, E9PG91, Q8NG96, Q9UHX3, Q9Y4B1
    UniProtKB/TrEMBL
    A0JNV7
    Related
    ENSP00000319883.3, ENST00000315576.8
    Conserved Domains (4) summary
    smart00303
    Location:479529
    GPS; G-protein-coupled receptor proteolytic site domain
    cd00054
    Location:119154
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:163210
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:533774
    7tm_4; Olfactory receptor
  3. NM_152916.2NP_690880.1  adhesion G protein-coupled receptor E2 isoform b precursor

    Status: REVIEWED

    Source sequence(s)
    AC005327, AC090427
    Consensus CDS
    CCDS32934.1
    UniProtKB/TrEMBL
    A0JNV7
    Related
    ENSP00000470725.1, ENST00000594294.5
  4. NM_152917.2NP_690881.1  adhesion G protein-coupled receptor E2 isoform c precursor

    Status: REVIEWED

    Source sequence(s)
    AC005327, AC090427
    Consensus CDS
    CCDS32933.1
    UniProtKB/TrEMBL
    A0JNV7
    Related
    ENSP00000472735.1, ENST00000594076.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    14724171..14778560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438720.1XP_047294676.1  adhesion G protein-coupled receptor E2 isoform X3

  2. XM_047438731.1XP_047294687.1  adhesion G protein-coupled receptor E2 isoform X17

  3. XM_047438728.1XP_047294684.1  adhesion G protein-coupled receptor E2 isoform X13

  4. XM_047438725.1XP_047294681.1  adhesion G protein-coupled receptor E2 isoform X11

  5. XM_047438729.1XP_047294685.1  adhesion G protein-coupled receptor E2 isoform X14

  6. XM_047438733.1XP_047294689.1  adhesion G protein-coupled receptor E2 isoform X19

  7. XM_047438732.1XP_047294688.1  adhesion G protein-coupled receptor E2 isoform X18

  8. XM_047438723.1XP_047294679.1  adhesion G protein-coupled receptor E2 isoform X8

  9. XM_047438730.1XP_047294686.1  adhesion G protein-coupled receptor E2 isoform X16

  10. XM_047438724.1XP_047294680.1  adhesion G protein-coupled receptor E2 isoform X9

  11. XM_047438721.1XP_047294677.1  adhesion G protein-coupled receptor E2 isoform X4

    Related
    ENSP00000472280.2, ENST00000596991.6
  12. XM_017026726.2XP_016882215.1  adhesion G protein-coupled receptor E2 isoform X5

    UniProtKB/TrEMBL
    A0JNV7
  13. XM_011527951.4XP_011526253.1  adhesion G protein-coupled receptor E2 isoform X6

    UniProtKB/TrEMBL
    A0JNV7
    Conserved Domains (4) summary
    smart00303
    Location:430480
    GPS; G-protein-coupled receptor proteolytic site domain
    cd00054
    Location:119154
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:163197
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:484725
    7tm_4; Olfactory receptor
  14. XM_011527949.3XP_011526251.1  adhesion G protein-coupled receptor E2 isoform X2

    UniProtKB/TrEMBL
    Q53GP0
    Related
    ENSP00000471297.1, ENST00000601345.5
    Conserved Domains (4) summary
    smart00303
    Location:468518
    GPS; G-protein-coupled receptor proteolytic site domain
    cd00054
    Location:119154
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:163210
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:522763
    7tm_4; Olfactory receptor
  15. XM_011527948.3XP_011526250.1  adhesion G protein-coupled receptor E2 isoform X1

    UniProtKB/TrEMBL
    A0JNV7
    Conserved Domains (4) summary
    smart00303
    Location:479529
    GPS; G-protein-coupled receptor proteolytic site domain
    cd00054
    Location:119154
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:163210
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:533774
    7tm_4; Olfactory receptor
  16. XM_011527953.3XP_011526255.1  adhesion G protein-coupled receptor E2 isoform X10

    UniProtKB/TrEMBL
    A0JNV7
    Related
    ENSP00000469277.1, ENST00000595839.5
    Conserved Domains (3) summary
    smart00303
    Location:386436
    GPS; G-protein-coupled receptor proteolytic site domain
    pfam07645
    Location:119153
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:440681
    7tm_4; Olfactory receptor
  17. XM_017026727.2XP_016882216.1  adhesion G protein-coupled receptor E2 isoform X15

    UniProtKB/TrEMBL
    Q53GP0
  18. XM_047438727.1XP_047294683.1  adhesion G protein-coupled receptor E2 isoform X12

  19. XM_011527952.4XP_011526254.1  adhesion G protein-coupled receptor E2 isoform X7

    UniProtKB/TrEMBL
    A0JNV7
    Conserved Domains (3) summary
    cd00054
    Location:119154
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:163210
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:475716
    7tm_4; Olfactory receptor
  20. XM_011527954.4XP_011526256.1  adhesion G protein-coupled receptor E2 isoform X20

    UniProtKB/TrEMBL
    A0JNV7
    Conserved Domains (4) summary
    smart00303
    Location:366416
    GPS; G-protein-coupled receptor proteolytic site domain
    cd00054
    Location:641
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:5097
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:420661
    7tm_4; Olfactory receptor
  21. XM_011527955.3XP_011526257.1  adhesion G protein-coupled receptor E2 isoform X21

    Conserved Domains (3) summary
    smart00303
    Location:280330
    GPS; G-protein-coupled receptor proteolytic site domain
    pfam07645
    Location:1347
    EGF_CA; Calcium-binding EGF domain
    cl21561
    Location:334575
    7tm_4; Olfactory receptor
  22. XM_047438736.1XP_047294692.1  adhesion G protein-coupled receptor E2 isoform X24

    UniProtKB/TrEMBL
    B4DWB8, E9PEL8
    Related
    ENSP00000376689.3, ENST00000392962.3
  23. XM_047438735.1XP_047294691.1  adhesion G protein-coupled receptor E2 isoform X23

  24. XM_047438734.1XP_047294690.1  adhesion G protein-coupled receptor E2 isoform X22

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    14850478..14906112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320779.1XP_054176754.1  adhesion G protein-coupled receptor E2 isoform X26

  2. XM_054320793.1XP_054176768.1  adhesion G protein-coupled receptor E2 isoform X17

  3. XM_054320783.1XP_054176758.1  adhesion G protein-coupled receptor E2 isoform X28

  4. XM_054320787.1XP_054176762.1  adhesion G protein-coupled receptor E2 isoform X29

  5. XM_054320778.1XP_054176753.1  adhesion G protein-coupled receptor E2 isoform X25

  6. XM_054320780.1XP_054176755.1  adhesion G protein-coupled receptor E2 isoform X27

  7. XM_054320789.1XP_054176764.1  adhesion G protein-coupled receptor E2 isoform X13

  8. XM_054320790.1XP_054176765.1  adhesion G protein-coupled receptor E2 isoform X14

  9. XM_054320795.1XP_054176770.1  adhesion G protein-coupled receptor E2 isoform X19

  10. XM_054320794.1XP_054176769.1  adhesion G protein-coupled receptor E2 isoform X18

  11. XM_054320784.1XP_054176759.1  adhesion G protein-coupled receptor E2 isoform X8

  12. XM_054320792.1XP_054176767.1  adhesion G protein-coupled receptor E2 isoform X16

  13. XM_054320785.1XP_054176760.1  adhesion G protein-coupled receptor E2 isoform X9

  14. XM_054320786.1XP_054176761.1  adhesion G protein-coupled receptor E2 isoform X10

  15. XM_054320781.1XP_054176756.1  adhesion G protein-coupled receptor E2 isoform X5

  16. XM_054320777.1XP_054176752.1  adhesion G protein-coupled receptor E2 isoform X2

  17. XM_054320797.1XP_054176772.1  adhesion G protein-coupled receptor E2 isoform X21

  18. XM_054320782.1XP_054176757.1  adhesion G protein-coupled receptor E2 isoform X7

  19. XM_054320791.1XP_054176766.1  adhesion G protein-coupled receptor E2 isoform X15

  20. XM_054320788.1XP_054176763.1  adhesion G protein-coupled receptor E2 isoform X12

  21. XM_054320796.1XP_054176771.1  adhesion G protein-coupled receptor E2 isoform X20

  22. XM_054320799.1XP_054176774.1  adhesion G protein-coupled receptor E2 isoform X24

  23. XM_054320798.1XP_054176773.1  adhesion G protein-coupled receptor E2 isoform X22

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152918.1: Suppressed sequence

    Description
    NM_152918.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_152919.1: Suppressed sequence

    Description
    NM_152919.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_152920.1: Suppressed sequence

    Description
    NM_152920.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  4. NM_152921.1: Suppressed sequence

    Description
    NM_152921.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.