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ERVW-1 endogenous retrovirus group W member 1, envelope [ Homo sapiens (human) ]

Gene ID: 30816, updated on 3-Jun-2018
Official Symbol
ERVW-1provided by HGNC
Official Full Name
endogenous retrovirus group W member 1, envelopeprovided by HGNC
Primary source
HGNC:HGNC:13525
See related
Ensembl:ENSG00000242950 MIM:604659; Vega:OTTHUMG00000131249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV
Summary
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
Expression
Restricted expression toward placenta (RPKM 37.5) See more
Orthologs
See ERVW-1 in Genome Data Viewer
Location:
7q21.2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (92468380..92477915, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (92097694..92107229, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene transmembrane BAX inhibitor motif containing 7, pseudogene Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 1 Neighboring gene GATA zinc finger domain containing 1 Neighboring gene ERVW-1 upstream regulatory region Neighboring gene peroxisomal biogenesis factor 1 Neighboring gene RNA binding motif protein 48

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-mediated regulation of MSRV and Syncytin-1 involves TLR-4 in primary astrocytes PubMed
tat HIV-1 Tat stimulates MSRV and inhibits Syncytin-1 in monocytes, while in primary astrocytes and differentiated macrophages Tat stimulates both MSRV and Syncytin-1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
plasma membrane fusion IDA
Inferred from Direct Assay
more info
PubMed 
syncytium formation IDA
Inferred from Direct Assay
more info
PubMed 
syncytium formation by plasma membrane fusion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
viral envelope IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
syncytin-1
Names
HERV-7q envelope protein
HERV-W Env glycoprotein
HERV-W envelope protein
HERV-W_7q21.2 provirus ancestral Env polyprotein
HERV-tryptophan envelope protein
endogenous retroviral family W, env(C7), member 1
endogenous retrovirus group W member 1
envelope glycoprotein
envelope polyprotein gPr73
enverin
human endogenous retrovirus W envC7-1 envelope protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130925.1NP_001124397.1  syncytin-1 precursor

    See identical proteins and their annotated locations for NP_001124397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF072506, BC137381
    Consensus CDS
    CCDS5626.1
    UniProtKB/Swiss-Prot
    Q9UQF0
    UniProtKB/TrEMBL
    D0EYG5
    Related
    ENSP00000474984.1, OTTHUMP00000272562, ENST00000603053.1, OTTHUMT00000468284
    Conserved Domains (1) summary
    pfam00429
    Location:22477
    TLV_coat; ENV polyprotein (coat polyprotein)
  2. NM_014590.3NP_055405.3  syncytin-1 precursor

    See identical proteins and their annotated locations for NP_055405.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer, unspliced transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF208161, BG012022, BX365066, BX391741
    Consensus CDS
    CCDS5626.1
    UniProtKB/Swiss-Prot
    Q9UQF0
    UniProtKB/TrEMBL
    D0EYG5
    Related
    ENSP00000419945.1, OTTHUMP00000161914, ENST00000493463.2, OTTHUMT00000254009
    Conserved Domains (1) summary
    pfam00429
    Location:22477
    TLV_coat; ENV polyprotein (coat polyprotein)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    92468380..92477915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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