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ST6GALNAC6 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 30815, updated on 13-Mar-2020

Summary

Official Symbol
ST6GALNAC6provided by HGNC
Official Full Name
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:23364
See related
Ensembl:ENSG00000160408 Ensembl:ENSG00000257524 MIM:610135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAT7F; SIAT7-F; ST6GALNACVI
Summary
ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in colon (RPKM 34.9), fat (RPKM 30.2) and 25 other tissues See more
Orthologs

Genomic context

See ST6GALNAC6 in Genome Data Viewer
Location:
9q34.11
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (127885321..127906764, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130647600..130669010, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr9.2869 Neighboring gene microRNA 4672 Neighboring gene adenylate kinase 1 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sialyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
cell-cell recognition IC
Inferred by Curator
more info
PubMed 
ganglioside biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ganglioside biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
glycoprotein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycosphingolipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycosylceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
sialylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Names
CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
ST6 -N-acetylgalactosaminide alpha-26-sialyltransferase 6
ST6 GalNAc alpha-2,6-sialyltransferase 6
epididymis secretory sperm binding protein
galNAc alpha-2,6-sialyltransferase VI
sialyltransferase 7F
sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F
NP_001273928.1
NP_001273929.1
NP_001273930.1
NP_001273931.1
NP_001273932.1
NP_038471.2
XP_011516912.1
XP_011516913.1
XP_016870148.1
XP_016870149.1
XP_016870150.1
XP_016870151.1
XP_016870152.1
XP_016870153.1
XP_016870154.1
XP_016870155.1
XP_016870156.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286999.1NP_001273928.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform b

    See identical proteins and their annotated locations for NP_001273928.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AY358672, BC007802, BC036102, BG699392
    Consensus CDS
    CCDS69669.1
    UniProtKB/Swiss-Prot
    Q969X2
    Related
    ENSP00000362235.1, ENST00000373142.5
    Conserved Domains (1) summary
    pfam00777
    Location:102266
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001287000.1NP_001273929.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform c

    See identical proteins and their annotated locations for NP_001273929.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region, resulting in translation initiation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
    Source sequence(s)
    AK023900, AY358672, BG699392
    Consensus CDS
    CCDS69668.1
    UniProtKB/Swiss-Prot
    Q969X2
    UniProtKB/TrEMBL
    A0A024R8C6
    Related
    ENSP00000362237.3, ENST00000373144.7
    Conserved Domains (1) summary
    pfam00777
    Location:68289
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. NM_001287001.1NP_001273930.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform c

    See identical proteins and their annotated locations for NP_001273930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
    Source sequence(s)
    AK057100, AY358672
    Consensus CDS
    CCDS69668.1
    UniProtKB/Swiss-Prot
    Q969X2
    UniProtKB/TrEMBL
    A0A024R8C6
    Related
    ENSP00000362234.1, ENST00000373141.5
    Conserved Domains (1) summary
    pfam00777
    Location:68289
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. NM_001287002.1NP_001273931.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform c

    See identical proteins and their annotated locations for NP_001273931.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
    Source sequence(s)
    AK310850, AY358672
    Consensus CDS
    CCDS69668.1
    UniProtKB/Swiss-Prot
    Q969X2
    UniProtKB/TrEMBL
    A0A024R8C6
    Related
    ENSP00000477575.1, ENST00000622357.4
    Conserved Domains (1) summary
    pfam00777
    Location:68289
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. NM_001287003.1NP_001273932.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform d

    See identical proteins and their annotated locations for NP_001273932.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation from a downstream in-frame start codon, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK057100, AK300534, AY358672
    Consensus CDS
    CCDS75908.1
    UniProtKB/Swiss-Prot
    Q969X2
    UniProtKB/TrEMBL
    B4DU80, F6SGE3
    Related
    ENSP00000438109.2, ENST00000542456.5
  6. NM_013443.4NP_038471.2  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform a

    See identical proteins and their annotated locations for NP_038471.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AY358672, BC007802, BG699392
    Consensus CDS
    CCDS6882.1
    UniProtKB/Swiss-Prot
    Q969X2
    UniProtKB/TrEMBL
    A0A0S2Z5G9
    Related
    ENSP00000362239.1, ENST00000373146.5
    Conserved Domains (1) summary
    pfam00777
    Location:96287
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_104629.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has alternate 5' exon structure and uses two alternate splice sites in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK310850, AY358672

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    127885321..127906764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014660.2XP_016870149.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X2

  2. XM_017014661.2XP_016870150.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X3

  3. XM_011518611.3XP_011516913.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X5

    See identical proteins and their annotated locations for XP_011516913.1

    UniProtKB/Swiss-Prot
    Q969X2
    UniProtKB/TrEMBL
    A0A024R8C6
    Conserved Domains (1) summary
    pfam00777
    Location:68289
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_017014659.2XP_016870148.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X1

    UniProtKB/Swiss-Prot
    Q969X2
    Conserved Domains (1) summary
    pfam00777
    Location:102266
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. XM_011518610.3XP_011516912.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X4

    See identical proteins and their annotated locations for XP_011516912.1

    UniProtKB/Swiss-Prot
    Q969X2
    UniProtKB/TrEMBL
    A0A0S2Z5G9
    Conserved Domains (1) summary
    pfam00777
    Location:96287
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. XM_017014665.1XP_016870154.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X5

    UniProtKB/Swiss-Prot
    Q969X2
    UniProtKB/TrEMBL
    A0A024R8C6
    Related
    ENSP00000495890.1, ENST00000643338.1
    Conserved Domains (1) summary
    pfam00777
    Location:68289
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. XM_017014666.2XP_016870155.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X5

    UniProtKB/Swiss-Prot
    Q969X2
    UniProtKB/TrEMBL
    A0A024R8C6
    Conserved Domains (1) summary
    pfam00777
    Location:68289
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  8. XM_017014662.2XP_016870151.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X3

  9. XM_017014663.1XP_016870152.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X3

  10. XM_017014667.2XP_016870156.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X5

    UniProtKB/Swiss-Prot
    Q969X2
    UniProtKB/TrEMBL
    A0A024R8C6
    Conserved Domains (1) summary
    pfam00777
    Location:68289
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  11. XM_017014664.1XP_016870153.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X3

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