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ST6GALNAC4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 27090, updated on 1-Jun-2020

Summary

Official Symbol
ST6GALNAC4provided by HGNC
Official Full Name
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:17846
See related
Ensembl:ENSG00000136840 MIM:606378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IV; SIAT3C; SIAT7D; SIAT3-C; SIAT7-D; ST6GalNAc; ST6GALNACIV
Summary
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 14.6), spleen (RPKM 9.7) and 24 other tissues See more
Orthologs

Genomic context

See ST6GALNAC4 in Genome Data Viewer
Location:
9q34.11
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (127907886..127917052, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130670165..130679326, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene microRNA 4672 Neighboring gene adenylate kinase 1 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase like 1 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
O-glycan processing TAS
Traceable Author Statement
more info
 
ganglioside biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycolipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sialylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase
Names
NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2, 6-sialyltransferase alpha2,6-sialyltransferase
NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase IV
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
ST6 GalNAc alpha-2,6-sialyltransferase 4
ST6 neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminidealpha-2,6-sialyltransferase 4
ST6GalNAc IV
sialyltransferase 3C
sialyltransferase 7D ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase)
NP_778204.1
NP_778205.1
XP_011516829.1
XP_011516831.1
XP_024303286.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175039.4NP_778204.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform a

    See identical proteins and their annotated locations for NP_778204.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL157935
    Consensus CDS
    CCDS6883.1
    UniProtKB/Swiss-Prot
    Q9H4F1
    UniProtKB/TrEMBL
    A0A024R881
    Related
    ENSP00000336733.5, ENST00000335791.10
    Conserved Domains (1) summary
    pfam00777
    Location:59254
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_175040.3NP_778205.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform b

    See identical proteins and their annotated locations for NP_778205.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region and utilizes a downstream in-frame start codon compared to variant 1. Variant 2 encodes isoform b which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    BC036705, CB126299, F27902
    UniProtKB/Swiss-Prot
    Q9H4F1
    UniProtKB/TrEMBL
    A8K7N4
    Related
    ENSP00000355130.3, ENST00000361444.3
    Conserved Domains (1) summary
    pfam00777
    Location:2205
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    127907886..127917052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518529.2XP_011516831.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:82172
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_011518527.3XP_011516829.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:82312
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_024447518.1XP_024303286.1  alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:59148
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_002956775.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014403.3: Suppressed sequence

    Description
    NM_014403.3: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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