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stat3 signal transducer and activator of transcription 3 (acute-phase response factor) [ Danio rerio (zebrafish) ]

Gene ID: 30767, updated on 23-Jun-2024

Summary

Official Symbol
stat3provided by ZNC
Official Full Name
signal transducer and activator of transcription 3 (acute-phase response factor)provided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-68
See related
Ensembl:ENSDARG00000022712 AllianceGenome:ZFIN:ZDB-GENE-980526-68
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
STAT3b1; STAT3b2; z-Stat3; wu:fc15d02; wu:fl59g06
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; cardiac muscle tissue regeneration; and generation of neurons. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including blastomere; epidermal superficial stratum; head; immature eye; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See stat3 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (17030665..17109944)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (16880851..16960144)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit a1a Neighboring gene caveolae associated protein 1a Neighboring gene signal transducer and activator of transcription 5a Neighboring gene phospholipase C like 5

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC193054

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within axis elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within hepatocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear receptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leptin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within notochord morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within posterior lateral line neuromast hair cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
signal transducer and activator of transcription 3
Names
signal transduction and activation of transcription 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131479.1NP_571554.1  signal transducer and activator of transcription 3

    See identical proteins and their annotated locations for NP_571554.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ005693
    UniProtKB/TrEMBL
    A0A8N7V0P2, O93599
    Related
    ENSDARP00000095292.4, ENSDART00000104519.6
    Conserved Domains (4) summary
    cd10374
    Location:555718
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2119
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:140320
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:322574
    STAT_bind; STAT protein, DNA binding domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    17030665..17109944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163796.3XP_005163853.1  signal transducer and activator of transcription 3 isoform X4

    See identical proteins and their annotated locations for XP_005163853.1

    UniProtKB/TrEMBL
    A0A8M2BAW6, Q6NV46
    Related
    ENSDARP00000075300.5, ENSDART00000080854.7
    Conserved Domains (4) summary
    cd10374
    Location:555718
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2119
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:140320
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:322574
    STAT_bind; STAT protein, DNA binding domain
  2. XM_021469347.1XP_021325022.1  signal transducer and activator of transcription 3 isoform X5

    UniProtKB/TrEMBL
    A0A0R4IGF2, A0A1S6L752
    Related
    ENSDARP00000134796.2, ENSDART00000159849.2
    Conserved Domains (4) summary
    cd10374
    Location:555718
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2119
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:140320
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:322574
    STAT_bind; STAT protein, DNA binding domain
  3. XM_005163793.4XP_005163850.2  signal transducer and activator of transcription 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BB24
    Conserved Domains (4) summary
    cd10374
    Location:570733
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:17134
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:155335
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:337589
    STAT_bind; STAT protein, DNA binding domain
  4. XM_005163794.4XP_005163851.2  signal transducer and activator of transcription 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BAX1
    Conserved Domains (4) summary
    cd10374
    Location:570733
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:17134
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:155335
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:337589
    STAT_bind; STAT protein, DNA binding domain
  5. XM_005163795.4XP_005163852.2  signal transducer and activator of transcription 3 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BBA1
    Conserved Domains (4) summary
    cd10374
    Location:570733
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:17134
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:155335
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:337589
    STAT_bind; STAT protein, DNA binding domain