stat3 signal transducer and activator of transcription 3 (acute-phase response factor) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: stat3provided by ZNC
Official Full Name: signal transducer and activator of transcription 3 (acute-phase response factor)provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-68
See related: Ensembl:ENSDARG00000022712 AllianceGenome:ZFIN:ZDB-GENE-980526-68
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: STAT3b1; STAT3b2; z-Stat3; wu:fc15d02; wu:fl59g06
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; embryonic morphogenesis; and neuron development. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including blastomere; bone tissue; epidermal superficial stratum; head; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (17030665..17108657)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (16880851..16960144)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stat3 Regulates Developmental Hematopoiesis and Impacts Myeloid Cell Function via Canonical and Non-Canonical Modalities.
Title: Stat3 Regulates Developmental Hematopoiesis and Impacts Myeloid Cell Function via Canonical and Non-Canonical Modalities.
Stat3 Has a Different Role in Axon Growth During Development Than It Does in Axon Regeneration After Injury.
Title: Stat3 Has a Different Role in Axon Growth During Development Than It Does in Axon Regeneration After Injury.
Contribution of Signal Transducer and Activator of Transcription 3 (STAT3) to Bone Development and Repair.
Title: Contribution of Signal Transducer and Activator of Transcription 3 (STAT3) to Bone Development and Repair.
Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation.
Title: Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation.
The stem-like Stat3-responsive cells of zebrafish intestine are Wnt/beta-catenin dependent.
Title: The stem-like Stat3-responsive cells of zebrafish intestine are Wnt/β-catenin dependent.
Stat3 is required for hepatocyte cell differentiation and liver regeneration.
Title: Stat3 Regulates Liver Progenitor Cell-Driven Liver Regeneration in Zebrafish.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a expression during oogenesis. Accordingly, restoring Cdc25a expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
Title: Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation.
PTPN9 plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 and ZBP-89.
Title: Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish.
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Title: Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
Title: Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

fc15d02.x1 (e-PCR)
- UniSTS:187766

stat3 (e-PCR), detects polymorphism
- UniSTS:205497

fi82g11.x1 (e-PCR)
- UniSTS:198083

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hepatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear receptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leptin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast hair cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regeneration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: signal transducer and activator of transcription 3

Names: signal transduction and activation of transcription 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131479.1 → NP_571554.1 signal transducer and activator of transcription 3

See identical proteins and their annotated locations for NP_571554.1

Status: PROVISIONAL

Source sequence(s)

AJ005693

UniProtKB/TrEMBL

A0A8N7V0P2, O93599

Related

ENSDARP00000095292.4, ENSDART00000104519.6

Conserved Domains (4) summary

cd10374
Location:555 → 718

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 119

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:140 → 320

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:322 → 574

STAT_bind; STAT protein, DNA binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

17030665..17108657

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163796.4 → XP_005163853.1 signal transducer and activator of transcription 3 isoform X4

See identical proteins and their annotated locations for XP_005163853.1

UniProtKB/TrEMBL

A0A8M2BAW6, Q6NV46

Related

ENSDARP00000075300.5, ENSDART00000080854.7

Conserved Domains (4) summary

cd10374
Location:555 → 718

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 119

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:140 → 320

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:322 → 574

STAT_bind; STAT protein, DNA binding domain
XM_021469347.2 → XP_021325022.1 signal transducer and activator of transcription 3 isoform X5

UniProtKB/TrEMBL

A0A0R4IGF2, A0A1S6L752

Related

ENSDARP00000134796.2, ENSDART00000159849.2

Conserved Domains (4) summary

cd10374
Location:555 → 718

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 119

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:140 → 320

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:322 → 574

STAT_bind; STAT protein, DNA binding domain
XM_005163795.5 → XP_005163852.2 signal transducer and activator of transcription 3 isoform X3

UniProtKB/TrEMBL

A0A8M2BBA1

Conserved Domains (4) summary

cd10374
Location:570 → 733

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:17 → 134

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:155 → 335

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:337 → 589

STAT_bind; STAT protein, DNA binding domain
XM_005163793.5 → XP_005163850.2 signal transducer and activator of transcription 3 isoform X1

UniProtKB/TrEMBL

A0A8M2BB24

Conserved Domains (4) summary

cd10374
Location:570 → 733

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:17 → 134

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:155 → 335

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:337 → 589

STAT_bind; STAT protein, DNA binding domain
XM_005163794.5 → XP_005163851.2 signal transducer and activator of transcription 3 isoform X2

UniProtKB/TrEMBL

A0A8M2BAX1

Conserved Domains (4) summary

cd10374
Location:570 → 733

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:17 → 134

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:155 → 335

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:337 → 589

STAT_bind; STAT protein, DNA binding domain