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HCRTR1 hypocretin receptor 1 [ Homo sapiens (human) ]

Gene ID: 3061, updated on 10-Oct-2019

Summary

Official Symbol
HCRTR1provided by HGNC
Official Full Name
hypocretin receptor 1provided by HGNC
Primary source
HGNC:HGNC:4848
See related
Ensembl:ENSG00000121764 MIM:602392
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OX1R
Summary
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See HCRTR1 in Genome Data Viewer
Location:
1p35.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (31617700..31632518)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32083290..32093214)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1226 Neighboring gene uncharacterized LOC105378626 Neighboring gene tubulointerstitial nephritis antigen like 1 Neighboring gene penta-EF-hand domain containing 1 Neighboring gene uncharacterized LOC105378628 Neighboring gene PEF1 and COL16A1 antisense RNA 1 Neighboring gene collagen type XVI alpha 1 chain Neighboring gene uncharacterized LOC101929444

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
orexin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
feeding behavior IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
orexin receptor type 1
Names
hypocretin (orexin) receptor 1
hypocretin receptor type 1
orexin receptor 1
ox-1-R
ox1-R

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001525.2NP_001516.2  orexin receptor type 1

    See identical proteins and their annotated locations for NP_001516.2

    Status: REVIEWED

    Source sequence(s)
    AK290521, BC074796, CO960455, DA803650
    Consensus CDS
    CCDS344.1
    UniProtKB/Swiss-Prot
    O43613
    Related
    ENSP00000384387.2, ENST00000403528.6
    Conserved Domains (1) summary
    cd15208
    Location:47369
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    31617700..31632518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446603.1XP_024302371.1  orexin receptor type 1 isoform X1

    Conserved Domains (1) summary
    cd15208
    Location:47369
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_024446605.1XP_024302373.1  orexin receptor type 1 isoform X1

    Conserved Domains (1) summary
    cd15208
    Location:47369
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_017001107.1XP_016856596.1  orexin receptor type 1 isoform X2

    UniProtKB/TrEMBL
    A6NMV7
    Related
    ENSP00000362809.1, ENST00000373705.1
  4. XM_024446602.1XP_024302370.1  orexin receptor type 1 isoform X1

    Related
    ENSP00000362810.5, ENST00000373706.9
    Conserved Domains (1) summary
    cd15208
    Location:47369
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_024446604.1XP_024302372.1  orexin receptor type 1 isoform X1

    Conserved Domains (1) summary
    cd15208
    Location:47369
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
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