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Hcrtr1 hypocretin (orexin) receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 230777, updated on 29-Oct-2019

Summary

Official Symbol
Hcrtr1provided by MGI
Official Full Name
hypocretin (orexin) receptor 1provided by MGI
Primary source
MGI:MGI:2385650
See related
Ensembl:ENSMUSG00000028778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ox1r; ox1-R; ox-1-R
Expression
Biased expression in bladder adult (RPKM 6.3), stomach adult (RPKM 2.7) and 12 other tissues See more
Orthologs

Genomic context

See Hcrtr1 in Genome Data Viewer
Location:
4; 4 D2.2
Exon count:
10
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130130217..130139594, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (129807461..129816406, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene collagen, type XVI, alpha 1 Neighboring gene predicted gene, 46871 Neighboring gene predicted gene, 40258 Neighboring gene penta-EF hand domain containing 1 Neighboring gene predicted gene, 40259 Neighboring gene tubulointerstitial nephritis antigen-like 1 Neighboring gene predicted gene, 52490

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC141357

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
orexin receptor activity ISO
Inferred from Sequence Orthology
more info
 
peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
feeding behavior IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
orexin receptor type 1
Names
hypocretin receptor type 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163027.1NP_001156499.1  orexin receptor type 1 isoform 1

    See identical proteins and their annotated locations for NP_001156499.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode isoform 1.
    Source sequence(s)
    AI852516, AK140137
    Consensus CDS
    CCDS18707.1
    UniProtKB/Swiss-Prot
    P58307
    Related
    ENSMUSP00000113198.2, ENSMUST00000120154.8
    Conserved Domains (1) summary
    cd15208
    Location:47369
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001305392.1NP_001292321.1  orexin receptor type 1 isoform 2

    See identical proteins and their annotated locations for NP_001292321.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, uses an alternate internal exon, and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AI852516, AL606925, BC119582
    UniProtKB/TrEMBL
    Q0VDP6
    Conserved Domains (2) summary
    cd14964
    Location:3861
    7tm_GPCRs; TM helix 5 [structural motif]
    cl28897
    Location:1194
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. NM_001357258.1NP_001344187.1  orexin receptor type 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, uses an alternate internal exon, and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AI852516, AK140137, AL606925
    Conserved Domains (2) summary
    cd14964
    Location:3861
    7tm_GPCRs; TM helix 5 [structural motif]
    cl28897
    Location:1194
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. NM_198959.2NP_945197.2  orexin receptor type 1 isoform 1

    See identical proteins and their annotated locations for NP_945197.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AI852516, AK140137, AL606925
    Consensus CDS
    CCDS18707.1
    UniProtKB/Swiss-Prot
    P58307
    Related
    ENSMUSP00000030562.6, ENSMUST00000030562.12
    Conserved Domains (1) summary
    cd15208
    Location:47369
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p6 C57BL/6J

    Range
    130130217..130139594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320156.2XP_017175645.1  orexin receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P58307
    Conserved Domains (1) summary
    cd15208
    Location:47369
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_017320157.2XP_017175646.1  orexin receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P58307
    Conserved Domains (1) summary
    cd15208
    Location:47369
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

Reference GRCm38.p6 NOD/MrkTac

Genomic

  1. NT_187023.1 Reference GRCm38.p6 NOD/MrkTac

    Range
    1730895..1739836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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