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HCRT hypocretin neuropeptide precursor [ Homo sapiens (human) ]

Gene ID: 3060, updated on 21-Dec-2019

Summary

Official Symbol
HCRTprovided by HGNC
Official Full Name
hypocretin neuropeptide precursorprovided by HGNC
Primary source
HGNC:HGNC:4847
See related
Ensembl:ENSG00000161610 MIM:602358
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OX; PPOX; NRCLP1
Summary
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See HCRT in Genome Data Viewer
Location:
17q21.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (42184060..42185452, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40336078..40337470, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RAB5C, member RAS oncogene family Neighboring gene uncharacterized LOC105371781 Neighboring gene Sharpr-MPRA regulatory region 9875 Neighboring gene potassium voltage-gated channel subfamily H member 4 Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5B Neighboring gene signal transducer and activator of transcription 5A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type 1 hypocretin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type 2 hypocretin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
eating behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
negative regulation of potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transmission of nerve impulse IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transmission of nerve impulse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sleep IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
temperature homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynapse IEA
Inferred from Electronic Annotation
more info
 
rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
secretory granule IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
orexin
Names
hypocretin (orexin) neuropeptide
prepro-orexin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011448.1 RefSeqGene

    Range
    5001..6393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001524.1NP_001515.1  orexin precursor

    See identical proteins and their annotated locations for NP_001515.1

    Status: REVIEWED

    Source sequence(s)
    AF041240
    Consensus CDS
    CCDS11421.1
    UniProtKB/Swiss-Prot
    O43612
    Related
    ENSP00000293330.1, ENST00000293330.1
    Conserved Domains (1) summary
    pfam02072
    Location:1130
    Orexin; Prepro-orexin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    42184060..42185452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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