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Hcrt hypocretin [ Mus musculus (house mouse) ]

Gene ID: 15171, updated on 30-May-2017
Official Symbol
Hcrtprovided by MGI
Official Full Name
hypocretinprovided by MGI
Primary source
MGI:MGI:1202306
See related
Ensembl:ENSMUSG00000045471 Vega:OTTMUSG00000002123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PPOX
Summary
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors Hcrtr1 and Hcrtr2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Sep 2015]
Orthologs
Location:
11 D; 11 63.6 cM
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (100761693..100762931, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (100623007..100624245, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RAB5C, member RAS oncogene family Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 4 Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5B

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC151320, MGC151346

Gene Ontology Provided by MGI

Function Evidence Code Pubs
neuropeptide hormone activity ISO
Inferred from Sequence Orthology
more info
 
type 1 hypocretin receptor binding ISO
Inferred from Sequence Orthology
more info
 
type 2 hypocretin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
eating behavior ISO
Inferred from Sequence Orthology
more info
 
excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
feeding behavior IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
negative regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
protein kinase C-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
temperature homeostasis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule ISO
Inferred from Sequence Orthology
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
orexin
Names
orexin A
orexin B
prepro-orexin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010410.2NP_034540.1  orexin precursor

    See identical proteins and their annotated locations for NP_034540.1

    Status: REVIEWED

    Source sequence(s)
    AF019566
    Consensus CDS
    CCDS25436.1
    UniProtKB/Swiss-Prot
    O55241
    UniProtKB/TrEMBL
    Q547R2
    Related
    ENSMUSP00000057578.3, OTTMUSP00000002040, ENSMUST00000055083.3, OTTMUST00000004304
    Conserved Domains (1) summary
    pfam02072
    Location:1129
    Orexin; Prepro-orexin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    100761693..100762931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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