U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cpox coproporphyrinogen oxidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 304024, updated on 27-Feb-2024

Summary

Official Symbol
Cpoxprovided by RGD
Official Full Name
coproporphyrinogen oxidaseprovided by RGD
Primary source
RGD:1311817
See related
Ensembl:ENSRNOG00000001654 AllianceGenome:RGD:1311817
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables coproporphyrinogen oxidase activity and identical protein binding activity. Involved in several processes, including protoporphyrinogen IX biosynthetic process; response to lead ion; and response to methylmercury. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 366.0), Liver (RPKM 175.8) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cpox in Genome Data Viewer
Location:
11q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_06 current mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (41936585..41946568, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (44039665..44049648, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene claudin domain containing 1 Neighboring gene G protein-coupled receptor 15 Neighboring gene ferritin domain containing 2 Neighboring gene ferritin heavy chain-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC124847

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables coproporphyrinogen oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables coproporphyrinogen oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables coproporphyrinogen oxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables coproporphyrinogen oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables structural constituent of eye lens IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of eye lens ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in heme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme B biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heme B biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme O biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heme O biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protoporphyrinogen IX biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protoporphyrinogen IX biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to arsenic-containing substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to inorganic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insecticide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to iron ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to methylmercury IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
Names
COX
coprogen oxidase
coproporphyrinogen-III oxidase, mitochondrial
coproporphyrinogenase
NP_001032172.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037095.1NP_001032172.1  oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001032172.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107664
    UniProtKB/Swiss-Prot
    Q3B7D0
    UniProtKB/TrEMBL
    A0A8L2UHB5
    Related
    ENSRNOP00000002257.5, ENSRNOT00000002257.7
    Conserved Domains (1) summary
    pfam01218
    Location:140442
    Coprogen_oxidas; Coproporphyrinogen III oxidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    55405778..55415761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)