U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cpox coproporphyrinogen oxidase [ Mus musculus (house mouse) ]

Gene ID: 12892, updated on 1-Mar-2024

Summary

Official Symbol
Cpoxprovided by MGI
Official Full Name
coproporphyrinogen oxidaseprovided by MGI
Primary source
MGI:MGI:104841
See related
Ensembl:ENSMUSG00000022742 AllianceGenome:MGI:104841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CPX; Cpo; HCP; cac; nct; M100835; Rgsc835
Summary
Enables coproporphyrinogen oxidase activity. A structural constituent of eye lens. Acts upstream of or within heme biosynthetic process. Located in membrane and mitochondrion. Is expressed in embryo and yolk sac. Used to study hereditary coproporphyria. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 163.4), liver E14.5 (RPKM 155.8) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cpox in Genome Data Viewer
Location:
16; 16 C1.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (58490571..58500754)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (58670208..58680391)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41100 Neighboring gene ferritin domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E7470 Neighboring gene predicted gene, 41464 Neighboring gene STARR-seq mESC enhancer starr_41101 Neighboring gene STARR-positive B cell enhancer ABC_E10915 Neighboring gene STARR-positive B cell enhancer ABC_E11620 Neighboring gene STARR-positive B cell enhancer ABC_E8640 Neighboring gene G protein-coupled receptor 15 Neighboring gene STARR-positive B cell enhancer ABC_E5551 Neighboring gene claudin domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Phenotypes

Associated conditions

Description Tests
Nakano cataract
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (2) 
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables P-type sodium:potassium-exchanging transporter activity TAS
Traceable Author Statement
more info
PubMed 
enables coproporphyrinogen oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables coproporphyrinogen oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables coproporphyrinogen oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of eye lens IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
Names
COX
Coproporphyrinogen III oxidase, mitochondrial precursor (Coproporphyrinogenase) (Coprogen oxidase) (COX)
clone 560
coprogen oxidase
coproporphyrinogen-III oxidase, mitochondrial
coproporphyrinogenase
NP_031783.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007757.2NP_031783.2  oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_031783.2

    Status: VALIDATED

    Source sequence(s)
    AC159200, BY728426, CA535096, CJ142773, D16333
    Consensus CDS
    CCDS49878.1
    UniProtKB/Swiss-Prot
    P36552, Q7TQ36, Q8VD08
    UniProtKB/TrEMBL
    Q3U029
    Related
    ENSMUSP00000055455.6, ENSMUST00000060077.7
    Conserved Domains (1) summary
    pfam01218
    Location:140442
    Coprogen_oxidas; Coproporphyrinogen III oxidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    58490571..58500754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)