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Rubcn rubicon autophagy regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 303885, updated on 13-Apr-2024

Summary

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Official Symbol
Rubcnprovided by RGD
Official Full Name
rubicon autophagy regulatorprovided by RGD
Primary source
RGD:1305422
See related
Ensembl:ENSRNOG00000059880 AllianceGenome:RGD:1305422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305422
Summary
Predicted to be involved in negative regulation of autophagosome maturation; negative regulation of endocytosis; and negative regulation of phosphatidylinositol 3-kinase activity. Predicted to be located in cytosol; endosome; and nucleoplasm. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 15. Orthologous to human RUBCN (rubicon autophagy regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 104.5), Adrenal (RPKM 93.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q22
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (81420261..81469415)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (67907534..67964347)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (71150506..71199254)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and calponin homology domain containing 3 Neighboring gene uncharacterized LOC134481085 Neighboring gene forty-two-three domain containing 1 Neighboring gene uncharacterized LOC103693588 Neighboring gene uncharacterized LOC134481084 Neighboring gene mucin 20, cell surface associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload. Akazawa Y, et al. Sci Rep, 2022 Jan 7. PMID 34996972, Free PMC Article
  2. The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression. Sun Q, et al. J Biol Chem, 2011 Jan 7. PMID 21062745, Free PMC Article
  3. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Matsunaga K, et al. Nat Cell Biol, 2009 Apr. PMID 19270696
  4. Mammalian autophagy: core molecular machinery and signaling regulation. Yang Z, et al. Curr Opin Cell Biol, 2010 Apr. PMID 20034776, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload.
    Title: Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol 3-kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
NOT located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Names
RUN and cysteine rich domain containing beclin 1 interacting protein
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427089.1 → NP_001414018.1  run domain Beclin-1-interacting and cysteine-rich domain-containing protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    81420261..81469415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088925.2 → XP_038944853.1  run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X3

    UniProtKB/TrEMBL
    A0A8I6GMR7
    Conserved Domains (2) summary
    smart00593
    Location:122 → 182
    RUN; domain involved in Ras-like GTPase signaling
    pfam13901
    Location:759 → 955
    zf-RING_9; Putative zinc-RING and/or ribbon

  2. XM_039088921.2 → XP_038944849.1  run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1

    UniProtKB/TrEMBL
    A0A0G2K687, A0A8I6GMR7, A6IRN7
    Related
    ENSRNOP00000073717.2
    Conserved Domains (2) summary
    smart00593
    Location:122 → 182
    RUN; domain involved in Ras-like GTPase signaling
    pfam13901
    Location:728 → 924
    zf-RING_9; Putative zinc-RING and/or ribbon

  3. XM_039088924.2 → XP_038944852.1  run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X2

    Conserved Domains (1) summary
    pfam13901
    Location:313 → 509
    zf-RING_9; Putative zinc-RING and/or ribbon
Nucleotide Protein Strain
Heading Accession and Version

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