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Rubcn RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein [ Mus musculus (house mouse) ]

Gene ID: 100502698, updated on 27-Jan-2018
Official Symbol
Rubcnprovided by MGI
Official Full Name
RUN domain and cysteine-rich domain containing, Beclin 1-interacting proteinprovided by MGI
Primary source
MGI:MGI:1915160
See related
Ensembl:ENSMUSG00000035629 Vega:OTTMUSG00000026856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rubicon; mKIAA0226; 5330403K09; 1700021K19Rik
Expression
Ubiquitous expression in spleen adult (RPKM 22.1), testis adult (RPKM 17.2) and 28 other tissues See more
Orthologs
See Rubcn in Genome Data Viewer
Location:
16; 16 B3
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (32821702..32877587, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (32790776..32868452, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene mucin 4 Neighboring gene mucin 20 Neighboring gene somatomedin B domain containing 1 Neighboring gene forty-two-three domain containing 1 Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 3 Neighboring gene predicted gene 6611 Neighboring gene IQ motif containing G

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...

Markers

Homology

Clone Names

  • KIAA0226, MGC76451, MGC79154

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagy IEA
Inferred from Electronic Annotation
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytosol ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
late endosome ISO
Inferred from Sequence Orthology
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Names
run domain Beclin-1 interacting and cystein-rich containing protein
run domain Beclin-1 interacting and cysteine-rich containing protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001200038.1NP_001186967.1  run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform a

    See identical proteins and their annotated locations for NP_001186967.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC139244, BC060601, BC067390, BP758360
    Consensus CDS
    CCDS49832.1
    UniProtKB/Swiss-Prot
    Q80U62
    Related
    ENSMUSP00000087114.3, OTTMUSP00000033324, ENSMUST00000089684.9, OTTMUST00000066488
    Conserved Domains (2) summary
    smart00593
    Location:123183
    RUN; domain involved in Ras-like GTPase signaling
    pfam13901
    Location:721921
    zf-RING_9; Putative zinc-RING and/or ribbon
  2. NM_172615.4NP_766203.1  run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform b

    See identical proteins and their annotated locations for NP_766203.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC139244, AK030368, BC067390, BP758360
    Consensus CDS
    CCDS28124.1
    UniProtKB/Swiss-Prot
    Q80U62
    Related
    ENSMUSP00000048811.8, OTTMUSP00000033323, ENSMUST00000040986.14, OTTMUST00000066486
    Conserved Domains (2) summary
    smart00593
    Location:123183
    RUN; domain involved in Ras-like GTPase signaling
    pfam13901
    Location:706906
    zf-RING_9; Putative zinc-RING and/or ribbon

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    32821702..32877587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521655.3XP_006521718.1  run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X3

    Related
    ENSMUSP00000113087.1, OTTMUSP00000033348, ENSMUST00000119810.1, OTTMUST00000066530
    Conserved Domains (2) summary
    smart00593
    Location:62122
    RUN; domain involved in Ras-like GTPase signaling
    pfam13901
    Location:685885
    zf-RING_9; Putative zinc-RING and/or ribbon
  2. XM_006521652.3XP_006521715.1  run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1

    Conserved Domains (2) summary
    smart00593
    Location:123183
    RUN; domain involved in Ras-like GTPase signaling
    pfam13901
    Location:746946
    zf-RING_9; Putative zinc-RING and/or ribbon
  3. XM_006521653.3XP_006521716.1  run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X2

    Conserved Domains (2) summary
    smart00593
    Location:123183
    RUN; domain involved in Ras-like GTPase signaling
    pfam13901
    Location:731931
    zf-RING_9; Putative zinc-RING and/or ribbon
  4. XM_017316835.1XP_017172324.1  run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X4

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