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Fbxw2 F-box and WD-40 domain protein 2 [ Mus musculus (house mouse) ]

Gene ID: 30050, updated on 12-May-2024

Summary

Official Symbol
Fbxw2provided by MGI
Official Full Name
F-box and WD-40 domain protein 2provided by MGI
Primary source
MGI:MGI:1353435
See related
Ensembl:ENSMUSG00000035949 AllianceGenome:MGI:1353435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MD6; FBW2; Fwd2; 2700071L08Rik
Summary
Located in cytoplasm. Is expressed in central nervous system; retina; and urinary system. Orthologous to human FBXW2 (F-box and WD repeat domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 8.5), bladder adult (RPKM 8.4) and 28 other tissues See more
Orthologs
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Genomic context

See Fbxw2 in Genome Data Viewer
Location:
2; 2 B
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34694185..34716229, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34804364..34826282, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene heat shock protein 5 Neighboring gene predicted gene, 53241 Neighboring gene STARR-seq mESC enhancer starr_04266 Neighboring gene STARR-seq mESC enhancer starr_04267 Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene STARR-seq mESC enhancer starr_04268 Neighboring gene STARR-seq mESC enhancer starr_04269 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Neighboring gene STARR-positive B cell enhancer ABC_E3369

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
F-box/WD repeat-containing protein 2
Names
F-box and WD-40 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164769.2NP_001158241.1  F-box/WD repeat-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001158241.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks the 3' exon, but has an alternate 3' sequence, compared to variant 1. The resulting isoform (2) is C-terminal truncated, compared to isoform 1.
    Source sequence(s)
    AL929106
    Consensus CDS
    CCDS50574.1
    UniProtKB/Swiss-Prot
    E9PXP3, Q60584
    UniProtKB/TrEMBL
    Q8BS25
    Related
    ENSMUSP00000108698.2, ENSMUST00000113075.8
    Conserved Domains (4) summary
    smart00256
    Location:6094
    FBOX; A Receptor for Ubiquitination Targets
    COG2319
    Location:140359
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:151185
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:140354
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001164770.2NP_001158242.1  F-box/WD repeat-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001158242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal segment in the 5' region, resulting in a downstream in-frame AUG start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL929106
    Consensus CDS
    CCDS50573.1
    UniProtKB/TrEMBL
    A2AUF9
    Related
    ENSMUSP00000088541.4, ENSMUST00000091020.10
    Conserved Domains (2) summary
    sd00039
    Location:2256
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11318
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001164772.2NP_001158244.1  F-box/WD repeat-containing protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001158244.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks several 3' exons, but has an alternate 3' sequence, compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL929106
    UniProtKB/TrEMBL
    Q99L53, Q9CPQ6
    Conserved Domains (4) summary
    smart00256
    Location:6094
    FBOX; A Receptor for Ubiquitination Targets
    COG2319
    Location:142236
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:151185
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:140232
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001379115.2NP_001366044.1  F-box/WD repeat-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL929106
    UniProtKB/TrEMBL
    A2AUF9
    Conserved Domains (2) summary
    sd00039
    Location:2256
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11318
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. NM_001379116.2NP_001366045.1  F-box/WD repeat-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL929106
    Conserved Domains (2) summary
    sd00039
    Location:2256
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11286
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. NM_001379117.2NP_001366046.1  F-box/WD repeat-containing protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL929106
    UniProtKB/TrEMBL
    Q8CCH8
    Conserved Domains (3) summary
    smart00256
    Location:6094
    FBOX; A Receptor for Ubiquitination Targets
    sd00039
    Location:151185
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:140415
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. NM_001379118.2NP_001366047.1  F-box/WD repeat-containing protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL929106
    Conserved Domains (3) summary
    smart00256
    Location:6094
    FBOX; A Receptor for Ubiquitination Targets
    sd00039
    Location:151185
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:140280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. NM_001406267.1NP_001393196.1  F-box/WD repeat-containing protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL929106
  9. NM_001406268.1NP_001393197.1  F-box/WD repeat-containing protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL929106
  10. NM_001406269.1NP_001393198.1  F-box/WD repeat-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL929106
    UniProtKB/TrEMBL
    Q9QUH1
    Related
    ENSMUSP00000028220.4, ENSMUST00000028220.10
  11. NM_001406270.1NP_001393199.1  F-box/WD repeat-containing protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL929106
    Related
    ENSMUSP00000108700.2, ENSMUST00000113077.8
  12. NM_001406271.1NP_001393200.1  F-box/WD repeat-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL929106
    UniProtKB/TrEMBL
    A2AUF9
  13. NM_001406272.1NP_001393201.1  F-box/WD repeat-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL929106
    UniProtKB/TrEMBL
    A2AUF9
  14. NM_001406273.1NP_001393202.1  F-box/WD repeat-containing protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL929106
  15. NM_001406274.1NP_001393203.1  F-box/WD repeat-containing protein 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL929106
  16. NM_001406275.1NP_001393204.1  F-box/WD repeat-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL929106
    UniProtKB/TrEMBL
    Q9CPQ6
  17. NM_001406276.1NP_001393205.1  F-box/WD repeat-containing protein 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL929106
    Related
    ENSMUST00000134323.2
  18. NM_001406277.1NP_001393206.1  F-box/WD repeat-containing protein 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL929106
    Related
    ENSMUST00000156130.2
  19. NM_001406278.1NP_001393207.1  F-box/WD repeat-containing protein 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL929106
  20. NM_001406279.1NP_001393208.1  F-box/WD repeat-containing protein 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL929106
  21. NM_013890.5NP_038918.3  F-box/WD repeat-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_038918.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL929106
    Consensus CDS
    CCDS15952.1
    UniProtKB/TrEMBL
    Q8CCH8, Q9QUH1
    Related
    ENSMUSP00000108703.3, ENSMUST00000113080.9
    Conserved Domains (3) summary
    smart00256
    Location:6094
    FBOX; A Receptor for Ubiquitination Targets
    sd00039
    Location:151185
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:140447
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    34694185..34716229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001164768.1: Suppressed sequence

    Description
    NM_001164768.1: This RefSeq was removed because currently there is insufficient support for the transcript.