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Fbxw2 F-box and WD-40 domain protein 2 [ Mus musculus (house mouse) ]

Gene ID: 30050, updated on 26-Sep-2022

Summary

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Official Symbol
Fbxw2provided by MGI
Official Full Name
F-box and WD-40 domain protein 2provided by MGI
Primary source
MGI:MGI:1353435
See related
Ensembl:ENSMUSG00000035949 AllianceGenome:MGI:1353435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MD6; FBW2; Fwd2; 2700071L08Rik
Summary
Located in cytoplasm. Is expressed in central nervous system; retina; and urinary system. Orthologous to human FBXW2 (F-box and WD repeat domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 8.5), bladder adult (RPKM 8.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxw2 in Genome Data Viewer
Location:
2; 2 B
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34694376..34716275, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34804364..34826282, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene heat shock protein 5 Neighboring gene small nucleolar RNA U13 Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Secondary structure analysis identifies a putative mouse protein demonstrating similarity to the repeat units found in CDC4, the G protein beta subunits and related proteins. Duff K, et al. DNA Seq, 1992. PMID 1296816
  2. Ubiquitination of NF-κB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance. Ren C, et al. Cell Death Differ, 2022 Feb. PMID 34465889, Free PMC Article
  3. Structure and expression of the gene encoding mouse F-box protein, Fwd2. Miura M, et al. Genomics, 1999 Nov 15. PMID 10585767
  4. Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10. Maruyama S, et al. Genomics, 2001 Dec. PMID 11735228
  5. Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Saiga T, et al. Mol Cell Biol, 2009 Jul. PMID 19398581, Free PMC Article

See all (24) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitination of NF-kappaB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance.
    Title: Ubiquitination of NF-κB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
F-box/WD repeat-containing protein 2
Names
F-box and WD-40 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164769.2 → NP_001158241.1  F-box/WD repeat-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001158241.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks the 3' exon, but has an alternate 3' sequence, compared to variant 1. The resulting isoform (2) is C-terminal truncated, compared to isoform 1.
    Source sequence(s)
    AL929106
    Consensus CDS
    CCDS50574.1
    UniProtKB/TrEMBL
    Q8BS25
    Related
    ENSMUSP00000108698.2, ENSMUST00000113075.8
    Conserved Domains (4) summary
    smart00256
    Location:60 → 94
    FBOX; A Receptor for Ubiquitination Targets
    COG2319
    Location:140 → 359
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:151 → 185
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:140 → 354
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001164770.2 → NP_001158242.1  F-box/WD repeat-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001158242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal segment in the 5' region, resulting in a downstream in-frame AUG start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL929106
    Consensus CDS
    CCDS50573.1
    UniProtKB/TrEMBL
    A0A6P5P9C6, A2AUF9
    Related
    ENSMUSP00000088541.4, ENSMUST00000091020.10
    Conserved Domains (2) summary
    sd00039
    Location:22 → 56
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11 → 318
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001164772.2 → NP_001158244.1  F-box/WD repeat-containing protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001158244.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks several 3' exons, but has an alternate 3' sequence, compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL929106
    UniProtKB/TrEMBL
    Q9CPQ6
    Conserved Domains (4) summary
    smart00256
    Location:60 → 94
    FBOX; A Receptor for Ubiquitination Targets
    COG2319
    Location:142 → 236
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:151 → 185
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:140 → 232
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_001379115.2 → NP_001366044.1  F-box/WD repeat-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL929106
    UniProtKB/TrEMBL
    A0A6P5P9C6, A2AUF9
    Conserved Domains (2) summary
    sd00039
    Location:22 → 56
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11 → 318
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. NM_001379116.2 → NP_001366045.1  F-box/WD repeat-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL929106
    Conserved Domains (2) summary
    sd00039
    Location:22 → 56
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11 → 286
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. NM_001379117.2 → NP_001366046.1  F-box/WD repeat-containing protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL929106
    Conserved Domains (3) summary
    smart00256
    Location:60 → 94
    FBOX; A Receptor for Ubiquitination Targets
    sd00039
    Location:151 → 185
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:140 → 415
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. NM_001379118.2 → NP_001366047.1  F-box/WD repeat-containing protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL929106
    Conserved Domains (3) summary
    smart00256
    Location:60 → 94
    FBOX; A Receptor for Ubiquitination Targets
    sd00039
    Location:151 → 185
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:140 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. NM_001406267.1 → NP_001393196.1  F-box/WD repeat-containing protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL929106

  9. NM_001406268.1 → NP_001393197.1  F-box/WD repeat-containing protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL929106

  10. NM_001406269.1 → NP_001393198.1  F-box/WD repeat-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL929106
    UniProtKB/TrEMBL
    A0A6P5PF07, A0A8C6HAJ7, Q9QUH1

  11. NM_001406270.1 → NP_001393199.1  F-box/WD repeat-containing protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL929106

  12. NM_001406271.1 → NP_001393200.1  F-box/WD repeat-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL929106
    UniProtKB/TrEMBL
    A0A6P5P9C6, A2AUF9

  13. NM_001406272.1 → NP_001393201.1  F-box/WD repeat-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL929106
    UniProtKB/TrEMBL
    A0A6P5P9C6, A2AUF9

  14. NM_001406273.1 → NP_001393202.1  F-box/WD repeat-containing protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL929106

  15. NM_001406274.1 → NP_001393203.1  F-box/WD repeat-containing protein 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL929106

  16. NM_001406275.1 → NP_001393204.1  F-box/WD repeat-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL929106
    UniProtKB/TrEMBL
    Q9CPQ6

  17. NM_001406276.1 → NP_001393205.1  F-box/WD repeat-containing protein 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL929106

  18. NM_001406277.1 → NP_001393206.1  F-box/WD repeat-containing protein 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL929106

  19. NM_001406278.1 → NP_001393207.1  F-box/WD repeat-containing protein 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL929106

  20. NM_001406279.1 → NP_001393208.1  F-box/WD repeat-containing protein 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL929106

  21. NM_013890.5 → NP_038918.3  F-box/WD repeat-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_038918.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL929106
    Consensus CDS
    CCDS15952.1
    UniProtKB/TrEMBL
    A0A6P5PF07, A0A8C6HAJ7, Q8CCH8, Q9QUH1
    Related
    ENSMUSP00000108703.3, ENSMUST00000113080.9
    Conserved Domains (3) summary
    smart00256
    Location:60 → 94
    FBOX; A Receptor for Ubiquitination Targets
    sd00039
    Location:151 → 185
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:140 → 447
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    34694376..34716275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498117.5 → XP_006498180.1  F-box/WD repeat-containing protein 2 isoform X1

    Conserved Domains (3) summary
    smart00256
    Location:97 → 131
    FBOX; A Receptor for Ubiquitination Targets
    sd00039
    Location:188 → 222
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:177 → 484
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001164768.1: Suppressed sequence

    Description
    NM_001164768.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60584.2 GenPept UniProtKB/Swiss-Prot:Q60584

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