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FBXW2 F-box and WD repeat domain containing 2 [ Homo sapiens (human) ]

Gene ID: 26190, updated on 3-Oct-2020

Summary

Official Symbol
FBXW2provided by HGNC
Official Full Name
F-box and WD repeat domain containing 2provided by HGNC
Primary source
HGNC:HGNC:13608
See related
Ensembl:ENSG00000119402 MIM:609071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Md6; FBW2; Fwd2
Summary
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 8.4), thyroid (RPKM 8.1) and 25 other tissues See more
Orthologs

Genomic context

See FBXW2 in Genome Data Viewer
Location:
9q33.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (120756974..120793440, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (123519254..123555740, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene multiple EGF like domains 9 Neighboring gene NFE2L2 motif-containing MPRA enhancer 171 Neighboring gene adenosylhomocysteinase pseudogene 2 Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene Sharpr-MPRA regulatory regions 2033 and 13781 Neighboring gene proteasome 26S subunit, non-ATPase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117371

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
F-box/WD repeat-containing protein 2
Names
F-box and WD-40 domain protein 2
F-box and WD-40 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375888.1NP_001362817.1  F-box/WD repeat-containing protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL138836, AL161911
    Conserved Domains (3) summary
    smart00256
    Location:6094
    FBOX; A Receptor for Ubiquitination Targets
    cd00200
    Location:140447
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:151185
    7WD40; WD40 repeat [structural motif]
  2. NM_001375889.1NP_001362818.1  F-box/WD repeat-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL138836, AL161911
    Conserved Domains (2) summary
    cd00200
    Location:11318
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2256
    7WD40; WD40 repeat [structural motif]
  3. NM_001375890.1NP_001362819.1  F-box/WD repeat-containing protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL138836, AL161911
  4. NM_012164.4NP_036296.2  F-box/WD repeat-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_036296.2

    Status: REVIEWED

    Source sequence(s)
    AL138836, AL161911, BC110334, DA703966
    Consensus CDS
    CCDS43872.1
    UniProtKB/Swiss-Prot
    Q9UKT8
    Related
    ENSP00000476369.1, ENST00000608872.6
    Conserved Domains (3) summary
    smart00256
    Location:6094
    FBOX; A Receptor for Ubiquitination Targets
    cd00200
    Location:140447
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:151185
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    120756974..120793440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717051.2XP_006717114.1  F-box/WD repeat-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006717114.1

    Conserved Domains (4) summary
    smart00256
    Location:92126
    FBOX; A Receptor for Ubiquitination Targets
    COG2319
    Location:174414
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:197232
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:194418
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_017014615.2XP_016870104.1  F-box/WD repeat-containing protein 2 isoform X4

    UniProtKB/Swiss-Prot
    Q9UKT8
    Conserved Domains (3) summary
    smart00256
    Location:6094
    FBOX; A Receptor for Ubiquitination Targets
    sd00039
    Location:165200
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:162382
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_017014617.1XP_016870106.1  F-box/WD repeat-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    B4DT60
    Conserved Domains (2) summary
    cd00200
    Location:11318
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2256
    7WD40; WD40 repeat [structural motif]
  4. XM_024447509.1XP_024303277.1  F-box/WD repeat-containing protein 2 isoform X4

    Conserved Domains (3) summary
    smart00256
    Location:6094
    FBOX; A Receptor for Ubiquitination Targets
    sd00039
    Location:165200
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:162382
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_006717049.3XP_006717112.1  F-box/WD repeat-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006717112.1

    Conserved Domains (4) summary
    smart00256
    Location:92126
    FBOX; A Receptor for Ubiquitination Targets
    COG2319
    Location:172433
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:172479
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:183217
    7WD40; WD40 repeat [structural motif]
  6. XM_017014616.1XP_016870105.1  F-box/WD repeat-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    B4DT60
    Conserved Domains (2) summary
    cd00200
    Location:11318
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2256
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_001746269.1 RNA Sequence

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