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SLC39A2 solute carrier family 39 member 2 [ Homo sapiens (human) ]

Gene ID: 29986, updated on 23-Nov-2021

Summary

Official Symbol
SLC39A2provided by HGNC
Official Full Name
solute carrier family 39 member 2provided by HGNC
Primary source
HGNC:HGNC:17127
See related
Ensembl:ENSG00000165794 MIM:612166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
6A1; ZIP2; ETI-1; ZIP-2
Summary
This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010]
Expression
Biased expression in skin (RPKM 12.0), esophagus (RPKM 8.3) and 3 other tissues See more
Orthologs
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Genomic context

See SLC39A2 in Genome Data Viewer
Location:
14q11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (20999293..21001871)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21467452..21470030)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 107 pseudogene Neighboring gene uncharacterized LOC101929718 Neighboring gene methyltransferase like 17 Neighboring gene NDRG family member 2 Neighboring gene microRNA 6717 Neighboring gene tubulin polymerization promoting protein family member 2 Neighboring gene ribonuclease A family member 13 (inactive)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119190

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables zinc ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in zinc ion transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in zinc ion transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
zinc transporter ZIP2
Names
Zrt- and Irt-like protein 2
solute carrier family 39 (zinc transporter), member 2
zinc uptake transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017065.1 RefSeqGene

    Range
    5039..7617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256588.2NP_001243517.1  zinc transporter ZIP2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and significantly shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AI382710, BC098274, BP359281, CN306082
    Consensus CDS
    CCDS58303.1
    UniProtKB/Swiss-Prot
    Q9NP94
    Related
    ENSP00000452568.1, ENST00000554422.5
    Conserved Domains (1) summary
    cl00437
    Location:574
    Zip; ZIP Zinc transporter
  2. NM_014579.4NP_055394.2  zinc transporter ZIP2 isoform a

    See identical proteins and their annotated locations for NP_055394.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK314974, D83039
    Consensus CDS
    CCDS9563.1
    UniProtKB/Swiss-Prot
    Q9NP94
    Related
    ENSP00000298681.4, ENST00000298681.5
    Conserved Domains (1) summary
    pfam02535
    Location:5306
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    20999293..21001871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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