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Slc39a2 solute carrier family 39 (zinc transporter), member 2 [ Mus musculus (house mouse) ]

Gene ID: 214922, updated on 27-Nov-2024

Summary

Official Symbol
Slc39a2provided by MGI
Official Full Name
solute carrier family 39 (zinc transporter), member 2provided by MGI
Primary source
MGI:MGI:2684326
See related
Ensembl:ENSMUSG00000072572 AllianceGenome:MGI:2684326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zip2; Gm289; ZIP-2; hZIP2; Gm1789; F730005G13Rik
Summary
Enables zinc ion transmembrane transporter activity. Involved in keratinocyte differentiation and zinc ion transmembrane transport. Acts upstream of or within zinc ion transport. Located in plasma membrane. Is expressed in several structures, including genitourinary system; gut; liver; spleen; and yolk sac. Orthologous to human SLC39A2 (solute carrier family 39 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 3.9), frontal lobe adult (RPKM 3.8) and 19 other tissues See more
Orthologs
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Genomic context

See Slc39a2 in Genome Data Viewer
Location:
14 C2; 14 26.71 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52130539..52134202)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51893082..51896745)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene eosinophil-associated, ribonuclease A family, member 6 Neighboring gene STARR-positive B cell enhancer ABC_E7309 Neighboring gene STARR-positive B cell enhancer ABC_E2424 Neighboring gene methyltransferase like 17 Neighboring gene N-myc downstream regulated gene 2 Neighboring gene tubulin polymerization-promoting protein family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC130599

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cadmium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cadmium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in zinc ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in zinc ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within zinc ion transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc transporter ZIP2
Names
solute carrier family 39 member 2
zrt- and Irt-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039676.2NP_001034765.2  zinc transporter ZIP2

    See identical proteins and their annotated locations for NP_001034765.2

    Status: VALIDATED

    Source sequence(s)
    AC125087, AK089322, BY200549
    Consensus CDS
    CCDS36914.1
    UniProtKB/Swiss-Prot
    G3X943, Q2HIZ9
    Related
    ENSMUSP00000038707.6, ENSMUST00000047726.12
    Conserved Domains (1) summary
    pfam02535
    Location:5306
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    52130539..52134202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518795.4XP_006518858.1  zinc transporter ZIP2 isoform X1

    See identical proteins and their annotated locations for XP_006518858.1

    Related
    ENSMUST00000160668.2
    Conserved Domains (1) summary
    cl00437
    Location:574
    Zip; ZIP Zinc transporter
  2. XM_006518796.5XP_006518859.1  zinc transporter ZIP2 isoform X1

    See identical proteins and their annotated locations for XP_006518859.1

    Conserved Domains (1) summary
    cl00437
    Location:574
    Zip; ZIP Zinc transporter