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ANAPC4 anaphase promoting complex subunit 4 [ Homo sapiens (human) ]

Gene ID: 29945, updated on 17-Nov-2020

Summary

Official Symbol
ANAPC4provided by HGNC
Official Full Name
anaphase promoting complex subunit 4provided by HGNC
Primary source
HGNC:HGNC:19990
See related
Ensembl:ENSG00000053900 MIM:606947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC4
Summary
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Expression
Ubiquitous expression in endometrium (RPKM 15.3), lymph node (RPKM 11.0) and 25 other tissues See more
Orthologs

Genomic context

See ANAPC4 in Genome Data Viewer
Location:
4p15.2
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (25377263..25418498)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (25378848..25420120)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase type 2 beta Neighboring gene zinc finger CCHC-type containing 4 Neighboring gene uncharacterized LOC105374536 Neighboring gene inositol-3-phosphate synthase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
GeneReviews: Not available
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
anaphase-promoting complex subunit 4
Names
cyclosome subunit 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286756.2NP_001273685.1  anaphase-promoting complex subunit 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC108218, AC110812, AK023597, BC059383, BI546948
    Consensus CDS
    CCDS68684.1
    UniProtKB/Swiss-Prot
    Q9UJX5
    UniProtKB/TrEMBL
    B3KN47
    Related
    ENSP00000426654.1, ENST00000510092.5
    Conserved Domains (3) summary
    sd00039
    Location:2459
    7WD40; WD40 repeat [structural motif]
    pfam12894
    Location:26118
    ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
    pfam12896
    Location:232431
    ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4
  2. NM_013367.3NP_037499.2  anaphase-promoting complex subunit 4 isoform 2

    See identical proteins and their annotated locations for NP_037499.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    BC059383, BI546948, CA312572
    Consensus CDS
    CCDS3434.1
    UniProtKB/Swiss-Prot
    Q9UJX5
    Related
    ENSP00000318775.3, ENST00000315368.7
    Conserved Domains (3) summary
    sd00039
    Location:2459
    7WD40; WD40 repeat [structural motif]
    pfam12894
    Location:26118
    ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
    pfam12896
    Location:232431
    ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    25377263..25418498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454027.1XP_024309795.1  anaphase-promoting complex subunit 4 isoform X3

    Conserved Domains (1) summary
    pfam12896
    Location:163
    ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4
  2. XM_017008138.2XP_016863627.1  anaphase-promoting complex subunit 4 isoform X3

    Conserved Domains (1) summary
    pfam12896
    Location:163
    ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4
  3. XM_011513838.1XP_011512140.1  anaphase-promoting complex subunit 4 isoform X1

    Conserved Domains (1) summary
    pfam12896
    Location:120319
    ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4
  4. XM_005248159.2XP_005248216.1  anaphase-promoting complex subunit 4 isoform X2

    Conserved Domains (1) summary
    pfam12896
    Location:163
    ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4

RNA

  1. XR_002959726.1 RNA Sequence

  2. XR_001741213.1 RNA Sequence

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